Timing of melanoma metastasis: Critical implications for treatment

A new research perspective was published in Oncotarget's Volume 15 on June 13, 2024, entitled, "When does a melanoma metastasize? Implications for management."

In this new perspective, researchers John F. Thompson and Gabrielle J. Williams from The University of Sydney, Royal Prince Alfred Hospital, and the University of Western Australia discussed melanoma and timing treatment. Selecting which patients with clinically localized melanoma require treatment other than wide excision of the primary tumor is based on the risk or presence of metastatic disease. This in turn is linked to survival. 

"Knowing if and when a melanoma is likely to metastasize is therefore of great importance." 

Several studies employing a range of different methodologies have suggested that many melanomas metastasize long before the primary lesion is diagnosed. Therefore, waiting for dissemination of metastatic disease to become evident before making systemic therapy available to these patients may be less effective than giving them post-operative adjuvant therapy initially if the metastatic risk is high. The identification of these high-risk patients will assist in selecting those to whom adjuvant systemic therapy can most appropriately be offered. 

"Further studies are required to better identify high-risk patients whose primary melanoma is likely to have already metastasized."

Source:
Journal reference:

Thompson, J. F., & Williams, G. J. (2024). When does a melanoma metastasize? Implications for management. Oncotarget. doi.org/10.18632/oncotarget.28591.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Cellular immunotherapy offers hope for solid tumors