At the Neuroscience 2025 conference, Bruker Corporation today announced the release of the xView Module for Ultima 2Pplus multiphoton microscopes to significantly extend imaging scale and experiment flexibility for advanced neuroscience research. This patent-pending upgrade enhances the field-of-view (FOV) of Ultima systems by more than 2.5 times to enable high-resolution imaging of neural activity across larger brain areas, without compromising speed or sensitivity.
The xView Module for Ultima 2Pplus Multiphoton Microscopes. Image Credit: Bruker
Engineered to meet the growing demands of systems neuroscience research, the xView Module empowers researchers to visualize more expansive neural circuits in tandem with optogenetic activation, using Bruker’s NeuraLight 3D Ultra Module for holographic photostimulation. This unprecedented commercial pairing of a vast imaging FOV with complementary large-volume optogenetics makes it possible to study input-output relationships and manipulate widespread neuronal networks for insights toward brain-wide connectivity and function. The xView Module is particularly suited for broader imaging studies of epileptic activity across the brain and circuit mapping for understanding mechanisms of Alzheimer's and Parkinson’s diseases.
“Over the past months I have been using xView to study the spatial and temporal properties of circuits across cortical brain regions, where the increase in FOV has been critical to achieve meaningful data,” said Associate Professor Caroline Runyan of the University of Pittsburgh, Department of Neuroscience. “I am excited to be able to combine this new capability with 3D optogenetics on our Ultima 2Pplus microscopes.”
The xView Module unlocks a new scale of imaging for neuroscience.
By expanding the FOV while maintaining optical precision, we are continuing to build upon the Ultima platform’s success and research capabilities and push the limits of imaging instrumentation. We are looking forward to seeing the benefits and discoveries this helps bring to the scientific community.”
Xiaomei Li, Ph.D., Vice President and General Manager, Bruker’s Fluorescence Microscopy Business
About the xView Module
xView Module extends the Ultima 2Pplus multiphoton microscope’s FOV using Bruker’s patented ETL correction, enabling high-resolution imaging across millimeter-scale brain regions. By compensating for common image aberrations in large fields of view, xView maintains near-standard point spread function performance while expanding FOV beyond conventional limits. In addition, the integration of xView with Ultima’s xCore FPGA electronics provides flexibility to record across larger areas with greater-than-video-rate speeds or with ultra-high fidelity, up to 8K resolution. The Ultima 2Pplus platform with SLM and xView Module provides the market’s most comprehensive solution for mesoscale neural circuit studies without sacrificing speed or resolution.
How can super-resolution technology help study neurotransmission?