1. Rosemary B Rosemary B United States says:

    Both chloroquine and the derivative molecule hydroxychloroquine have in vitro activity against SARS-CoV and SARS-CoV-2.2,3 Hydroxychloroquine is thought to impair the terminal glycosylation of the angiotensin-converting–enzyme 2 (ACE2) receptor, which is the binding site for the envelope spike glycoprotein and has been shown to inhibit endolysosome function.2,4 In addition, hydroxychloroquine may have greater in vitro activity against SARS-CoV-2 than chloroquine.3

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