Sponsored Content by Bio-TechneJan 8 2024Reviewed by Olivia Frost
Bio-Techne’s next-generation platforms offer solutions for characterizing vaccine products quickly, accurately, and reliably. This enables the quick delivery of safe and effective products to the market.
Maurice
Maurice is an automated capillary electrophoresis (CE) platform that combines imaged capillary isoelectric focusing (icIEF) and capillary electrophoresis sodium dodecyl sulfate (CE-SDS) detection modes in a single compact, user-friendly instrument.
Maurice delivers high-quality, reproducible data for evaluating the identity, charge heterogeneity, and purity of proteins and delivery vectors for vaccines like lipid nanoparticles for mRNA vaccines, such as those approved for the market for COVID-19.
Image Credit: Bio-Techne
MFI
Micro-Flow Imaging (MFI), precisely and accurately identifies subvisible particles in solution, allowing for direct detection of contaminants and aggregates in vaccine products, which can be crucial for guaranteeing safety and efficacy. The MFI 5000 series can be automated with the Bot1 autosampler, giving the user time to work on other tasks.
Image Credit: Bio-Techne
Additional publications
Researchers at the Institute of Medicinal and Pharmaceutical Chemistry at the University of Braunschweig utilized Maurice cIEF to assess the isoelectric point (pI) of various SARS-CoV-2 proteins and verify the theoretical pI ranges derived from the amino acid sequences of these proteins.
In the study titled “Quantitation of CRM197 Using Imaged Capillary Isoelectric Focusing With Fluorescence Detection and Capillary Western,” icIEF with fluorescence detection on Maurice is utilized to characterize a prevalent carrier protein for polysaccharide conjugate-based vaccines.
Microcarriers are utilized to increase bioreactor surface area for growing cell-culture-derived vaccines. In the study titled “Cell Confluency Analysis on Microcarriers by Micro-Flow Imaging,” researchers utilized MFI to determine the cell coverage and confluency of these microcarriers.
In a study titled “Impact of Formulation and Suspension Properties on Redispersion of Aluminum-Adjuvanted Vaccines,” MFI was employed to evaluate the resuspendability of aluminum adjuvant-containing vaccines based on various formulation conditions.
Researchers also utilized MFI to evaluate protein aggregation to develop hyaluronan-based dissolving microneedles for intradermal vaccination. This is discussed in the paper titled “Hyaluronan-Based Dissolving Microneedles With High Antigen Content for Intradermal Vaccination: Formulation, Physicochemical Characterization and Immunogenicity Assessment.”
About Bio-Techne
Bio-Techne Corporation is a leading developer and manufacturer of high-quality purified proteins - notably cytokines and growth factors, antibodies, immunoassays, as well as biologically active small molecule compounds - which are sold to biomedical researchers and clinical research laboratories; these operations constitute the core Biotech Division, headquartered in Minneapolis, Minnesota.
The Protein Platform Division manufactures innovative protein analysis tools under the ProteinSimple brand name that greatly automate western blotting and immunoassay practices. The Diagnostics Division manufactures FDA-regulated controls, calibrators, blood gas, and clinical chemistry controls for OEM customers and clinical customers. Bio-Techne products assist scientific investigations into biological processes and the nature and progress of specific diseases. They aid in drug discovery efforts and provide the means for accurate clinical tests and diagnoses.
With thousands of products in its portfolio, Bio-Techne generated approximately $563 million in net sales in fiscal 2017 and has approximately 1,800 employees worldwide.
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