Endocrine News and Research

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PFAS exposure increases gestational diabetes risk

A review of 130 studies links PFAS exposure to gestational diabetes, highlighting the need for further research on diabetes outcomes and environmental factors.

19 Jan 2026

Ashwagandha aids recovery without blunting training stress in athletes

Six weeks of Ashwagandha root extract supplementation in semi-professional team-sport athletes was associated with sex-specific effects during pre-season training. Females showed improved perceived recovery with stable cortisol, while males demonstrated gains in lower-body power with stable cortisone levels.

18 Jan 2026

DLL3 on circulating tumor cells predicts tarlatamab success in lung cancer

A team led by investigators at the Mass General Brigham Cancer Institute has discovered that a particular marker on tumor cells circulating in the blood indicates whether a patient with lung cancer will experience a lasting response to a newly approved immunotherapy called tarlatamab.

14 Jan 2026

Endocrine-disrupting chemicals and adverse life events during pregnancy affect children's development

Research at Karlstad University shows that exposure to endocrine-disrupting chemicals and adverse life events during pregnancy can influence children's behavior and brain development.

14 Jan 2026

Low-dose megestrol strengthens hormone therapy in ER-positive breast cancer

Low-dose megestrol enhances hormone therapy for ER-positive breast cancer, reducing tumor proliferation and improving treatment adherence in the PIONEER trial.

7 Jan 2026

The gut is not just digestive and new evidence shows it actively controls brain function

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

6 Jan 2026

AI-powered optical imaging helps surgeons identify thyroid cancer in real time

Thyroid cancer is the most common endocrine cancer, affecting more people each year as detection rates continue to rise.

6 Jan 2026

Novel method can generate functional organoids from human adult adipose tissue

A recent study published in Engineering has unveiled a novel approach to generating functional organoids from human adult adipose tissue.

30 Dec 2025

Minimal residual disease monitoring can transform breast cancer care

Despite major therapeutic advances, breast cancer remains prone to recurrence, particularly in patients with early-stage disease who appear disease-free after treatment.

30 Dec 2025

Paternal microplastic exposure alters metabolic health in offspring

A study led by biomedical scientists at the University of California, Riverside, has shown for the first time that a father's exposure to microplastics (MPs) can trigger metabolic dysfunctions in his offspring.

23 Dec 2025

New CPRIT awards expand cancer prevention and treatment research in South Texas

UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), received nearly $3 million in new academic and prevention awards as part of the latest funding round announced by the Cancer Prevention Research Institute of Texas (CPRIT).

19 Dec 2025

Indoor environments expose people to a growing mix of new contaminants

Indoor dust, air and everyday products are exposing people to a growing mix of "new contaminants" inside homes, schools and workplaces, according to a new perspective published in the journal New Contaminants.

13 Dec 2025

Skipping sentinel lymph node biopsy may be safe for some early-stage breast cancer patients

Skipping sentinel lymph node biopsy (SLNB) in patients with clinically node-negative, hormonal receptor (HR)-positive, HER2-negative early-stage breast cancer did not compromise regional control or survival after a median five years of follow-up, according to results from the BOOG 2013-08 phase III clinical trial, presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

11 Dec 2025

What happens to your body during an ultramarathon? New study reveals key metabolic changes

This study tracked ultramarathon runners across 100 km, 160.9 km, and 230 km events to examine real-world metabolic, hormonal, and muscle stress responses. Severe energy deficits, muscle damage, and heterogeneous hormonal shifts were observed, with the greatest strain seen in the 230 km distance.

10 Dec 2025

AI model improves recurrence risk stratification in HR-positive, HER2-negative breast cancer

An artificial intelligence (AI) model created by integrating clinical, molecular, and histopathological data significantly improved recurrence risk stratification in hormone receptor (HR)-positive, HER2-negative breast cancer, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Next-generation oral SERD therapy lowers the risk of breast cancer recurrence

In an international study led by UCLA, researchers have shown that giredestrant, a next-generation oral selective estrogen receptor antagonist and degrader (SERD), when given as an adjuvant therapy for early-stage (1-3) hormone receptor (HR)-positive, HER2-negative breast cancer, significantly lowered the risk of the disease returning when compared with standard hormone therapies long considered the backbone of treatment.

10 Dec 2025

Everyday PFAS exposure alters placental function in early pregnancy

This study measured real-life PFAS concentrations in first-trimester human placentas and used these data to create a pregnancy-relevant PFAS mixture. In 3D trophoblast spheroid models, the mixture altered invasion, hormone secretion, and gene expression without broadly reducing viability at environmentally relevant doses.

8 Dec 2025

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

In a new trial, patients with B-acute lymphoblastic leukemia (B-ALL) who had no evidence of remaining cancer cells after prior treatment, experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation (TBI), the standard conditioning regimen used before hematopoietic cell transplantation.

7 Dec 2025

Study uncovers strategy to sensitize estrogen receptor–positive breast tumors to immunotherapy

A study led by researchers at the Hospital del Mar Research Institute advances one of the most significant milestones in breast cancer treatment, making immunotherapy effective against the most common tumor type, estrogen receptor-positive or luminal breast cancer.

4 Dec 2025

Study links endocrine-disrupting chemicals to hidradenitis suppurativa

A Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), which mostly affects skin folds, is believed to be the first to provide evidence that hormone-disrupting chemicals commonly found in ultra-processed food and single-use water bottles may contribute to the development of or worsen the condition in some people.

1 Dec 2025