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Unlocking the potential of double negative memory B cells in cancer treatment

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood – known as the tertiary lymphoid structure – where they become frustratingly dysfunctional when in close contact with tumors.

19 Feb 2025

New atlas reveals aging’s impact on breast tissue and cancer risk

Aging is a privilege, but it also brings risks-including an increased likelihood of developing age-related diseases including cancer.

13 Feb 2025

New immune map uncovers key pancreatic cancer insights

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic cancer cells.

12 Feb 2025

Mental health drives med student dropout rate

Around 1 in 5 UK medical students considers dropping out of medical school, with mental health issues a key contributor to their intention to abandon medicine, suggest the results of an observational study published in the open access journal BMJ Open.

11 Feb 2025

How lymphoid tissues protect against viral infections

Researchers explore the cellular and molecular adaptations associated with human secondary lymphoid tissue in adults during viral infection.

7 Feb 2025

Study reveals copper may raise fibromyalgia risk, iron could offer relief

A new study using Mendelian randomization suggests that higher copper levels may increase fibromyalgia risk, while iron may have a protective effect.

3 Feb 2025

Single heat stroke exposure triggers long-term health risks and metabolic vulnerabilities

The study links exertional heat stroke to chronic disorders, revealing impacts on body mass regulation and heart health, especially in high-fat diet scenarios.

3 Feb 2025

Immune system discovery could revolutionize treatment for chronic disease and cancer

A discovery about the mechanisms that enable the immune system to sustain long-term protection could revolutionize treatment for chronic disease and cancer.

31 Jan 2025

Researchers develop T cell growth method that enhances cancer-fighting ability in melanoma model

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

31 Jan 2025

How your immune system ages: Scientists reveal key changes over a lifetime

Scientists mapped how the human immune system evolves from birth to old age, revealing key changes that influence health, disease resistance, and aging. Their immune age model could help predict immune health and guide early interventions.

30 Jan 2025

Compressed workweeks help employees detach but do not reduce burnout risk

Condensing workweeks into fewer days to enjoy more days off, what are the implications for employee well-being? New longitudinal research from Ghent University at IKEA Belgium challenges policymakers' assumptions about the benefits of compressed work schedules, revealing both their potential and limitations in promoting workplace well-being.

27 Jan 2025

Two-thirds of people with post-COVID-19 syndrome experience long-term effects

Two-thirds of people with post-COVID-19 syndrome have persistent, objective symptoms – including reduced physical exercise capacity and reduced cognitive test performances – for a year or more, with no major changes in symptom clusters during the second year of their illness, according to a new study published January 23rd in the open-access journal PLOS Medicine by Winfried Kern of Freiburg University, Germany, and colleagues.

23 Jan 2025

Research reveals emotional and work-life strain in infertility treatment patients

Infertility is a problem that affects between 8% and 12% of couples of reproductive age worldwide – for some of them, the problem interrupts a life project, which is the desire to have children and build a family.

21 Jan 2025

Gut microbes and plant foods: a powerful duo for healthy aging

Gut microbiota and phytochemicals synergize to produce bioactive metabolites that combat aging, reduce inflammation, and enhance healthspan by supporting gut and systemic health.

20 Jan 2025

CAR-T cells carry memory of past antigen encounters

Researchers at the University of Colorado Anschutz Medical Campus have discovered that some CAR-T cells engineered to fight cancer and other conditions carry the memory of past encounters with bacteria, viruses and other antigens within them, a finding that may allow scientists to manufacture the cells in more precise and targeted ways.

2 Jan 2025