Exhaustion News and Research

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Specialized bone marrow niches reveal secrets of immune tolerance

Researchers have uncovered a hierarchical structure of immune-privileged stem cells in bone marrow niches, revealing their regenerative potential and therapeutic relevance.

2 Jan 2025

Nutrient metabolism regulates T cell exhaustion and therapy potential

Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic changes in immunity.

17 Dec 2024

Exosomes: A double-edged sword in hepatocellular carcinoma

The TIME is a dynamic network composed of cancer cells, immune cells, and stromal components. During the early stages of tumorigenesis, the TIME attempts to eliminate abnormal cells through immune surveillance.

11 Dec 2024

TCR sequencing sheds light on tumor immune interactions in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) stands as the dominant form of liver cancer, ranking as the fourth leading cause of cancer-related deaths globally.

11 Dec 2024

Short, daily reflection sessions help health care workers combat burnout

Watching short, web-based tutorials that inspire health care workers to contemplate awe, gratitude and kindness can promote enduring improvements in mental health outcomes such as depression and emotional exhaustion.

10 Dec 2024

How measles, whooping cough, and worse could roar back on RFK Jr.’s watch

The availability of safe, effective covid vaccines less than a year into the pandemic marked a high point in the 300-year history of vaccination, seemingly heralding an age of protection against infectious diseases.

6 Dec 2024

Study finds T cell exhaustion in chronic fatigue syndrome patients

Chronic fatigue syndrome creates conditions where pathogen-killing immune T cells become exhausted, according to a new Cornell University study.

3 Dec 2024

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

27 Nov 2024

Study reveals how cancer cells evade chemotherapy in low-glucose environments

Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows.

26 Nov 2024

Researchers seek to develop noninvasive diagnostics for chronic fatigue syndrome

Chronic fatigue syndrome (CFS) is a complex and long-term illness characterized by extreme fatigue that doesn't improve with rest, and can worsen with physical activity.

21 Nov 2024

CAR T cell therapy breakthroughs bring new hope for treating solid tumors

Researchers advance CAR T cell therapy for solid tumors by innovating ways to overcome the unique barriers of solid tumor environments, with promising clinical results.

13 Nov 2024

Prolonged mental fatigue can impair self-control and increase aggression

Prolonged mental fatigue can wear down brain areas crucial for the individual ability to self-control, and cause people to behave more aggressively.

11 Nov 2024

New approach reinvigorates exhausted T cells to improve tumor control

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells - which have lost their cancer-fighting oomph - consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

8 Nov 2024

Modulating CD39 expression to enhance CAR-T cell therapy against hepatocellular carcinoma

In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a recent study has identified a pivotal role for CD39 expression in modulating the function of CAR-T cells.

5 Nov 2024

New overtime limits for physicians aimed at improving sleep and mental health

Physicians are a vital component of the healthcare landscape and along with other medical professionals, they ensure timely diagnosis, treatment, and management of complex illnesses.

4 Nov 2024

3D tumor mapping reveals new insights into cancer biology and treatment

A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells - and the cells of a tumor's surrounding environment - are organized, in 3D, and how that organization changes when a tumor spreads to other organs.

1 Nov 2024

Urgent need to shift focus from fossil fuels to health

As multiple health threats from climate change break dangerous new records, the 2024 Report of The Lancet Countdown on Health and Climate Change calls for the trillions of dollars spent funding fossil fuels to be redirected and used to drive a rapid and fair transition to a net zero greenhouse gas (GHG) economy, instead of harming the health of billions of people across the world.

30 Oct 2024

Research uncovers intrinsic factors influencing CAR-T cell success

Researchers from the Josep Carreras Leukaemia Research Institute have found that the efficacy of varni-cel, a CAR-T infusion product for B-ALL patients, is highly dependent on intrinsic features of the CAR-T cells themselves and their progression within the patient.

29 Oct 2024

How a proposed federal heat rule might have saved these workers’ lives

On a sweltering afternoon in July 2020, Belinda Ramones got a call that her brother was in the hospital. The call was from a woman at the Florida landscaping business that he had joined that week, the Davey Tree Expert Co., Ramones said. By the time she arrived, she said, "My brother was swollen up from hands to toes."

28 Oct 2024

Study links dehydration to muscle cramps in IRONMAN athletes

As athletes prepare to dive into Hawaiian waters for the first part of the IRONMAN World Championship on Oct. 26, they may want to pay a little extra attention to the water inside their bodies.

23 Oct 2024