Hepatology News and Research

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Hepatology is the branch of medicine that incorporates study of liver, gallbladder, biliary tree and pancreas as well as management of their disorders.

HO-1 regulates liver fibrosis in NAFLD through the SIRT1 TGF-β Smad3 pathway

Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase activated by nicotinamide adenine dinucleotide, which may impact the transforming growth factor-β (TGF-ß)/Smad3 pathway in nonalcoholic fatty liver disease (NAFLD)-related liver fibrosis.

2 May 2025

MASLD in children linked to increased mortality and chronic complications

Researchers from University of California San Diego have found that children diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD) are at significantly increased risk of premature death and serious long-term health complications.

28 Apr 2025

Blood proteins offer early warning for liver disease

Scientists have identified five specific blood proteins that can accurately predict a person's risk for developing a serious form of liver disease as early as 16 years before they experience symptoms, enabling early intervention and possible prevention and treatment, according to a study to be presented at Digestive Disease Week (DDW) 2025.

25 Apr 2025

Four specific gene mutations linked to development and progression of lethal stomach cancers

Researchers using next-generation DNA sequencing have identified four specific genes whose mutations are linked to the development and progression of lethal stomach cancers.

25 Apr 2025

AGA announces $2.4 million in research funding for 74 recipients

The American Gastroenterological Association (AGA) is proud to announce the selection of 74 recipients to receive $2.4 million in research funding through the annual AGA Research Foundation Awards Program.

22 Apr 2025

Study shows how alcohol combined with burn trauma throws the intestinal microbiome into chaos

What happens in your gut after a night of heavy drinking and a severe burn injury? According to a new study, it might involve more than just pain and discomfort.

22 Apr 2025

Ursolic acid modulates estrogen conversion to alleviate MASLD inflammation

The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been escalating annually, positioning it as the leading cause of chronic liver disease worldwide.

21 Apr 2025

Evaluating hydronidone for the treatment of chronic hepatitis B-associated liver fibrosis

Liver fibrosis is a key process in the progression of chronic liver diseases. However, there are currently no drugs specifically designed to treat liver fibrosis.

18 Apr 2025

Study examines how COX-2 regulates ferroptosis in chronic liver injury

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. +

18 Apr 2025

Comparing single cell RNA methods to improve gastrointestinal cancer research

Research on gastrointestinal diseases, especially cancer, has mainly looked at the epithelial cells, which line the surfaces of organs, are important for various functions, and are believed to be the cells that go awry to cause these diseases.

16 Apr 2025

Gut bacteria turn bile acids into allies against cancer

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators.

16 Apr 2025

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea's role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored.

15 Apr 2025

Fecal microbiota transplantation emerges as a promising approach to H. pylori eradication

FMT is a novel therapeutic approach that involves transferring microbiota from a healthy donor to a patient's gastrointestinal tract.

10 Apr 2025

Gum disease linked to worsening liver health

There is growing recognition in medicine that what happens in one part of the body can ripple through others.

9 Apr 2025

Genetic research offers hope for children with rare intestinal disorders

Further genetic testing would show that Sophie has one of a group of rare conditions called CODE (congenital diarrhea and enteropathies) that disrupts the function of cells in the intestine, causing diarrhea and preventing infants from absorbing the nutrients they need to grow and thrive.

3 Apr 2025

Cedars-Sinai study investigates diet's role in treating gut disorders

A new study from Cedars-Sinai examined whether a specialized diet could improve symptoms of gastrointestinal disorders linked to an imbalance in gut microbiota.

1 Apr 2025

Harnessing intestinal microbes to combat inflammation and infections

Despite being an everyday necessity, nutrition is something of a black box. We know that many plant-based foods are good for us, but we don't always know why.

27 Mar 2025

Diagnostic colonoscopy follow-up unaffected by COVID-19 surge, despite screening delays

Two recent studies by researchers from Regenstrief Institute and the Indiana University School of Medicine explore the effect of the pandemic on colorectal cancer screening tests and diagnostic colonoscopies in Central Indiana. The findings of temporary disruption to the former and minimal impact on the latter are similar to findings across the U.S., contributing to the compendium of knowledge on preventive health uptake and subsequent treatment in various populations during the pandemic.

27 Mar 2025

Targeting PCSK9 and APOA4 for the treatment of TMAO-induced cholelithiasis

Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota.

25 Mar 2025

Besifovir dipivoxil maleate offers comparable efficacy and improved safety for hepatitis B patients

Hepatitis B is a liver infection cause by the hepatitis B virus (HBV), and long-term hepatitis B infections that last longer than six months are considered "chronic".

24 Mar 2025