Mouse Model News and Research

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Collaboration advances EMA601 as potential first-in-class stroke therapy

Boehringer Ingelheim and the Lower Franconian biotech company EMFRET Analytics have signed a cooperation and license agreement for the preclinical development program of the GPVI‑blocking antibody EMA601.

30 Mar 2026

Study reveals CAR T approach for hard-to-treat solid tumors

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma.

30 Mar 2026

Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.

29 Mar 2026

Gut immune responses found to trigger brain inflammation in MS

Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS).

27 Mar 2026

New AI system maps gene expression across the whole body

Understanding gene expression within the body has been a boon for 21st century biology and therapeutics, but most discoveries that use these technologies only focus on one organ or one small area of tissue.

27 Mar 2026

Early testosterone surge triggers rare muscle disease

Spinal and Bulbar Muscular Atrophy (SBMA) is a rare inherited disease that causes progressive muscle weakness and wasting in men.

27 Mar 2026

Heart failure and atrial fibrillation share underlying genetic and molecular mechanisms

New research published in Nature Cardiovascular Research reveals that heart failure and atrial fibrillation share underlying genetic and molecular mechanisms, suggesting that the two cardiovascular conditions may be less distinct than previously thought.

26 Mar 2026

New brain atlas reveals how the human neocortex forms over time

In a bid to better understand, and potentially treat, a host of conditions that affect early cognition, neurodevelopment and the brain later in life, investigators at Johns Hopkins Medicine and colleagues throughout the world have been mapping the molecular construction of the human brain.

25 Mar 2026

Cancer-fighting antibodies may trigger autoimmune brain disorders

Consider two seemingly unrelated medical puzzles. First: Every day, our bodies produce hundreds of billions of new cells, many of which are mutated.

25 Mar 2026

Mild hypoxia in preterm infants linked to lifelong memory issues

During intensive care after preterm births, babies can experience low oxygen in their tissue and cells-or hypoxia.

23 Mar 2026

Machine learning speeds up AMP discovery for treating ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent intestinal inflammation, abdominal pain and diarrhea.

23 Mar 2026

Study identifies protein biomarker and potential treatment for schizophrenia

Current schizophrenia medications treat symptoms such as hallucinations and delusions, but do little for cognitive symptoms like disorganized thinking or executive dysfunction.

19 Mar 2026

Muscle-repairing macrophages trigger heterotopic ossification in mice

We have identified a macrophage population "Mrep" that plays an essential role in muscle repair. However, in Fibrodysplasia ossificans progressiva (FOP), Mrep functions as a pathogenic cell that triggers heterotopic ossification.

18 Mar 2026

Key gene mutation disrupts the brain’s ability to update beliefs in schizophrenia patients

One of the symptoms of schizophrenia is difficulty incorporating new information about the world. This can lead patients to struggle with making decisions and, eventually, to lose touch with reality.

18 Mar 2026

Modified lipid nanoparticles boost mRNA vaccines while reducing side effects

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever and general malaise.

17 Mar 2026

Engineered bacteria may improve precision cancer drug delivery

Every year, millions of people are diagnosed with cancer globally; however, current treatments are limited by disease complexity.

17 Mar 2026

Activating hypoxia signaling improves metabolism and bone health

Obesity is widely known for increasing the risk of diabetes and cardiovascular disease, but its damaging effects on the skeleton are often overlooked. Excess body fat can disrupt bone metabolism, weaken bone quality, and impair fracture repair.

17 Mar 2026

Researchers develop targeted delivery system for poorly soluble cancer drugs

Recent advances in drug discovery research have led to the development of numerous drug candidate compounds with high therapeutic efficacy.

16 Mar 2026

New method creates longer lasting CAR T cells for cancer therapy

A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments.

13 Mar 2026

Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare.

13 Mar 2026