Small Molecules News and Research

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Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

14 Mar 2025

New tissue engineering strategies for spinal cord injury repair

A recent study published in the journal Engineering delves into the application of tissue engineering in spinal cord injury (SCI) repair, presenting a comprehensive review of the latest research and potential treatment strategies.

12 Mar 2025

Integrated anti-aging strategy could reduce neurodegeneration

Aging significantly impacts neurodegeneration, increasing risks for diseases like Alzheimer's. Research focuses on therapies to enhance cognitive function.

11 Mar 2025

Eradivir begins Phase 2 challenge study for antiviral therapeutic EV25

Eradivir, a clinical-stage small molecule immunotherapy biotech company, announced it has begun a Phase 2 challenge study with its antiviral therapeutic, EV25. The study will provide safety and efficacy data gathered from otherwise healthy participants infected with influenza then later treated with EV25.

7 Mar 2025

Scientists uncover structure of key enzyme to block cancer cell energy supply

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal cells maintain a balance of energy.

6 Mar 2025

Novel strategy targets beta cell dysfunction in type 2 diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

4 Mar 2025

Study elucidates mechanism connecting ER membrane remodeling to pyroptosis in cancer cells

Pyroptosis, a highly inflammatory type of programmed cell death, has garnered attention for its potential in cancer treatment.

3 Mar 2025

Researchers discover key blood molecules impacting child development

McMaster University researchers have identified small molecules in the blood that may impact early childhood development, showing how dietary exposures, early life experiences, and gut health can influence a child's growth and cognitive milestones.

28 Feb 2025

Macrophages use bacteria to build vital nutrients and control inflammation

Immune cells that eat bacteria in the body don't stash them in specialized compartments as once thought, but turn them into critical nutrients that build proteins, create energy and keep the cells alive, according to a new study from scientists at the University of Colorado Anschutz Medical Campus.

27 Feb 2025

Microphysiological systems in drug discovery

NewsMedical speaks with CN Bio about the translatability between in vitro organ-on-a-chip (OOC) models, microphysiological systems, and their in vivo counterparts.

From CN Bio 26 Feb 2025

Using quorum sensing inhibitors as a novel approach to address antibiotic resistance

Pseudomonas aeruginosa is notorious for its role in food spoilage and infections, posing a significant threat to both food safety and human health.

25 Feb 2025

Study uncovers pathway behind age-related degeneration of eye glands

A team led by Mount Sinai researchers has identified stem cell populations and mechanisms underlying age-related degeneration in glands that are vital to eye function.

24 Feb 2025

LUC7 proteins play crucial role in efficient RNA splicing

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut out and the coding portions are spliced back together.

21 Feb 2025

Epigenetic inhibitors show promise in malaria treatment

Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen.

20 Feb 2025

Protein identified as key to preventing fat build-up and related diseases

Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat molecules.

11 Feb 2025

Innovative approach to synthesizing functional molecules with triple click chemistry

Middle molecules with a molecular weight of more than 1,000 are difficult to synthesize due to multiple steps and time-consuming nature, demanding the development of a new approach that can overcome these disadvantages.

11 Feb 2025

Optibrium widens access to industry-leading docking method

Optibrium, a leading developer of software and AI solutions for molecular design today announced the introduction of a new PyMOL Graphical User Interface (GUI) for Surflex-Dock, its industry-leading structure-based design method, which is part of the company’s BioPharmics 3D molecular modelling suite.

5 Feb 2025