Stomach News and Research

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Oral GLP-1 drug orforglipron achieves significant weight loss in global trial

Patients taking an experimental oral GLP-1 drug lost significant weight and improved their heart and metabolic risk factors in a large, international, phase III clinical trial led by investigators at Weill Cornell Medicine, McMaster University, York University and other institutions

18 Sep 2025

Scientists unveil new obesity drug that reprograms fat and energy use

Details of a new drug that aims to treat the underlying causes of obesity are being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September).

18 Sep 2025

Low dose of aspirin cuts recurrence risk in colorectal cancer with genetic mutation

A Swedish-led research team at Karolinska Institutet and Karolinska University Hospital has shown in a new randomized clinical trial that a low dose of the well-known medicine aspirin halves the risk of recurrence after surgery in patients with colon and rectal cancer with a certain type of genetic alteration in the tumor.

17 Sep 2025

The 15th AACR cancer progress report highlights scientific advances

The American Association for Cancer Research (AACR) released the 15th edition of its annual Cancer Progress Report. A cornerstone of the AACR's educational and advocacy efforts, this comprehensive report provides the latest statistics on cancer incidence, mortality, and survivorship and highlights how federal investments in basic, translational, and clinical cancer research and cancer-related population sciences have led to impressive scientific advances that are improving health and saving lives.

17 Sep 2025

Mathematical model recreates swallowing and reveals causes of dysphagia

For most people, swallowing is second nature, but how does it occur, and why do some people have difficulty with it? Researchers at Kyushu University in Japan have started to tackle these questions by developing a mathematical model that recreates the muscle movements of the esophagus that occur during swallowing.

16 Sep 2025

Individuals taking semaglutide for weight loss experience less food noise than before

New research being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) shows that individuals who are taking semaglutide for weight loss experience less food noise than before.

16 Sep 2025

Researchers reveal why global gains against chronic diseases are stalling

Researchers analysed mortality data from 185 countries and found that while global non-communicable disease (NCD) deaths before age 80 declined from 2010 to 2019, progress slowed compared to 2001–2010. Gains were mainly from drops in heart disease and stroke, but rising burdens from diabetes, cancers, and neuropsychiatric conditions stalled momentum.

15 Sep 2025

Waning Japanese encephalitis immunity linked to more severe dengue illness

Scientists from Duke-NUS Medical School, in collaboration with researchers in Nepal, have found that waning immunity to Japanese encephalitis virus (JEV) may increase the risk of more severe dengue disease in humans.

13 Sep 2025

UC researcher wins $300,000 grant to investigate the underlying causes of eosinophilic esophagitis

Patients with eosinophilic esophagitis (EoE) often describe the condition as painful, disruptive and frightening.

11 Sep 2025

New genetic test redefines diagnosis and management of hereditary pancreatitis

A new genetic test developed at Mayo Clinic is redefining how clinicians diagnose and manage hereditary pancreatitis.

11 Sep 2025

Mucus-inspired hydrogel improves healing in animal models of gastric injury

Hydrogels-materials like gelatin that can absorb and hold water-can aid wound healing and enable slow-release drug delivery, but they usually break down in acidic environments like the stomach.

4 Sep 2025

Fluorine-containing medicines do not increase adverse drug reactions

Medicines containing a type of PFAS or 'forever chemical' called fluorine are not leading to higher numbers of adverse drug reactions according to new data analysis.

2 Sep 2025

Select groups of myocardial infarction patients benefit from Helicobacter pylori screening

Not all acute myocardial infarction patients should be offered routine screening for the stomach ulcer bacterium Helicobacter pylori.

1 Sep 2025

Cancer-related nerve injury triggers inflammation and immunotherapy resistance

Cancer cells can break down the protective covers around nerves, causing nerve injury that triggers chronic inflammation leading to immune exhaustion and eventual resistance to immunotherapy, according to new research from The University of Texas MD Anderson Cancer Center.

1 Sep 2025

Cellular purging process may help injured cells revert to stem cell-like state more rapidly

Now, a new study in mice led by researchers at Washington University School of Medicine in St. Louis and the Baylor College of Medicine reveals a previously unknown cellular purging process that may help injured cells revert to a stem cell-like state more rapidly.

29 Aug 2025

New swallowable device enables noninvasive gut nerve stimulation

Scientists have long struggled with how to study the gut's vast nervous system - often called the body's 'second brain' - without damaging it.

28 Aug 2025

Increasing numbers of bariatric surgery patients turn to GLP-1 drugs

Bariatric surgery is usually effective on its own for weight loss, but an increasing proportion of patients who undergo bariatric surgery start taking one of the new glucagon-like 1 peptide receptor agonist (GLP-1) weight-loss drugs in the years after their surgery, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

27 Aug 2025

Transcutaneous vagal nerve stimulation shows promise for gastrointestinal disorders

Imbalanced autonomic function, characterized by reduced vagal activity and sympathetic dominance, is increasingly recognized in various gastrointestinal (GI) disorders.

27 Aug 2025

GLP-1 receptor agonists improve heart failure outcomes and reduce environmental impact

New research has found that the use of GLP-1 receptor agonists, a class of medications commonly prescribed for patients with obesity and diabetes, reduces the environmental footprint of healthcare and clinical outcomes when used to treat heart failure.

27 Aug 2025

Engineering digital twins to transform diagnosis and treatment for GI disorders

For many people, gastrointestinal (GI) disorders are chronic and life-altering conditions. Yet despite their prevalence, doctors are often challenged by patients experiencing persistent symptoms with no way to accurately identify and diagnose diseases.

25 Aug 2025