Newly developed metamaterial can potentially transform ingestible and implantable medical devices

Researchers led by Rice University's Yong Lin Kong have developed a soft but strong metamaterial that can be controlled remotely to rapidly transform its size and shape. The invention, published in Science Advances, represents a significant advancement that can potentially transform ingestible and implantable medical devices.

Metamaterials are synthetic constructs that exhibit unusual properties not typically found in natural materials. Instead of relying solely on chemical composition, the effective behavior of these materials is primarily determined by the physical structure, i.e. the specific shape, arrangement and scale of their building blocks. 

The new metamaterial designed by Kong and the team at Rice possesses a unique combination of stability and deformability, which the researchers say has never been achieved in such soft structures before. This metamaterial is also remarkably strong - it can sustain compressive loads more than 10 times its weight and maintains performance in temperatures that far exceed physiological conditions as well as harsh chemical environments.

We programmed multistability, i.e. the ability to exist in multiple stable states, into the soft structure by incorporating geometric features such as trapezoidal supporting segments and reinforced beams. These elements create an energy barrier that locks the structure into its new shape even after the external actuation force is removed." 

Yong Lin Kong, assistant professor of mechanical engineering at Rice's George R. Brown School of Engineering and Computing

The metamaterial's soft architecture helps address critical medical safety concerns such as gastric ulcers, puncture injuries and inflammation that can occur from implantable and ingestible devices made of rigid components.

Kong and his team used 3D printing to create molds that form interconnected microarchitectures of tilted beams and supporting segments. This design allows for rapid switching between open (off) and closed (on) states, and the transformed configuration is maintained even after the magnetic field is removed. By combining many such unit cells as "building blocks," they form a 3D structure that can not only transform its shape but can also produce complex peristaltic motions to move or to deliver fluids in a controlled manner when actuated with a magnetic field. 

Importantly, the material continued to function reliably even after prolonged exposure to mechanical stress and acidic corrosion, conditions that mimic the harsh environment of the human stomach.

"The metamaterial makes it possible to remotely control the size and shape of devices inside the body. This could enable lifesaving capabilities such as precisely controlling where a device stays, delivering medication where it's needed or applying targeted mechanical forces deep inside the body," Kong said. "We are now leveraging this metamaterial to develop ingestible systems that may one day treat obesity in humans or improve the health of marine mammals, and we are collaborating with surgeons at the Texas Medical Center to design wireless fluidic control systems to address unmet clinical needs."

The first author of this study was Kong's first graduate student, Taylor Greenwood, who has since graduated and started a faculty position at Brigham Young University. Kong's other graduate students Brian Elder and Jared Anklam, postdoctoral associates Jian Teng and Saebom Lee and other collaborators were involved in the study. This research was supported by the National Institutes of Health and the Office of Naval Research.