Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Using antibodies to detect Alzheimer’s disease

News-Medical speaks to Professor Vendruscolo about his research that uses antibodies to detect Alzheimer's disease, which could help to improve drug discovery.

8 Jun 2020

Discovery of new killing mechanism could help design improved teixobactin-based drugs

Scientists at the University of Liverpool and University of Utrecht have taken another step forward on their quest to develop a viable drug based on teixobactin - a new class of potent natural antibiotic capable of killing superbugs.

5 Jun 2020

Focusing on clinical drug research for dementia

Frontiers in Clinical Drug Research - Dementia is a book series which presents comprehensive reviews about research on Dementia, a term which references the loss of brain function associated with Alzheimer's disease and other related medical conditions.

5 Jun 2020

Biorelate offers free access to AI-based drug discovery tool: Galactic

Biorelate, a UK-based AI start up, is offering all researchers free use of Galactic, its cloud-based web tool, to support biomedical research while lab access is restricted around the world.

From Biorelate Ltd 4 Jun 2020

Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

Hesperos Inc., pioneers of the Human-on-a-Chip in vitro system, today announced the publication of a new peer-reviewed publication that describes how the company’s technology can be used to investigate immune responses following treatment with biological therapeutics for multi-organ systemic diseases, including cancer, infectious diseases and inflammatory disorders.

4 Jun 2020

New test identifies CAD-affected children who may benefit from uridine

Scientists at Sanford Burnham Prebys Medical Discovery Institute and the Centro de Biología Molecular Severo Ochoa in Spain have created a test that determines which children with CAD deficiency - a rare metabolic disease - are likely to benefit from receiving uridine, a nutritional supplement that has dramatically improved the lives of other children with the condition.

3 Jun 2020

KinaRx receives SBIR grant to speed up clinical trials for AML and other diseases

Acute myeloid leukemia (AML), an aggressive blood cancer, is one of the most lethal cancers. More than 19,000 new cases are diagnosed a year, and more than 11,000 people a year die from it, according to the American Cancer Society.

3 Jun 2020

Gene discovery in fruit flies could lead to treatments for age-related hearing loss

Scientists at UCL have discovered sets of regulatory genes, which are responsible for maintaining healthy hearing. The finding, made in fruit flies, could potentially lead to treatments for age-related hearing loss (ARHL) in humans.

2 Jun 2020

A new tool to help biomedical scientists better understand COVID-19 virus

Biomedical scientists working with COVID-19 have a new tool to help them better understand the virus and feel confident about the structural models they are using in their research.

2 Jun 2020

AstraZeneca implements Genestack’s flagship Omics Data Manager

Genestack Ltd. today announced that its flagship multi-omics data catalogue, curation and integrative search product, Omics Data Manager (ODM), has been licensed and implemented by AstraZeneca.

30 May 2020

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer's disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy.

29 May 2020

New project launched to find novel treatments for rare genetic diseases

The University Carlos III Madrid, Almirall, S.A. and the MEDINA Foundation have launched a project to find new treatments for recessive dystrophic epidermolysis bullosa and other genetic diseases caused by nonsense mutations.

28 May 2020

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

SignalChem, a global leader in cell signaling and protein engineering, has been conducting research on new coronaviruses since the outbreak of the virus.

From SignalChem Biotech Inc. 28 May 2020

Measuring the binding of SARS-CoV-2 antibodies to the COVID spike protein using SPR

Ryan Denomme, the CEO of Nicoya, speaks to News-Medical on their SARS-CoV-2 research using their SPR technology.

From Nicoya Lifesciences 28 May 2020

A new therapeutic approach to improve the health of diabetic patients

Scientists at Sanford Burnham Prebys Medical Discovery Institute have mapped for the first time the vast network of proteins that interact with proinsulin, the protein the body normally processes into insulin.

27 May 2020

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

The first patients have been dosed in a multi-regional Phase IIB randomized, placebo-controlled clinical trial for the treatment of hepatitis B-associated liver cancer.

19 May 2020

X-ray experiments demonstrate a new way to block the entry of SARS-CoV-2

As scientists across the globe race to develop a vaccine against SARS-CoV-2, the coronavirus that causes COVID-19, an international team led by Davide Corti at Vir Biotechnology and David Veesler at the University of Washington has been working around the clock on a complementary approach - identifying neutralizing antibodies that could be used as a preventative treatment or as a post-exposure therapy.

19 May 2020

CELLINK announces partnership with AstraZeneca to provide advanced 3D-bioprinted liver organoids

CELLINK, focused on the development and commercialization of innovative bioprinting technologies and bioinks, announced today that the company will collaborate with AstraZeneca to provide advanced 3D-bioprinted liver organoids for drug discovery purposes in cardiovascular, renal and metabolic diseases.

From CELLINK 15 May 2020

Study provides new insights on mechanisms that promote cancer

Like subway com muters on a crowded train, cells generally prefer not to be packed in too tightly. In fact, they have set up mechanisms to avoid this, a phenomenon called "contact inhibition." A hallmark of cancer cells is that they lack this contact inhibition, and instead become pushy, facilitating their spread.

14 May 2020

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Scientists around the globe are working to identify approved and investigational drugs that can be repurposed to treat COVID-19.

13 May 2020

Drug Discovery News and Research

Further Reading

Using antibodies to detect Alzheimer’s disease

Discovery of new killing mechanism could help design improved teixobactin-based drugs

Focusing on clinical drug research for dementia

Biorelate offers free access to AI-based drug discovery tool: Galactic

Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

New test identifies CAD-affected children who may benefit from uridine

KinaRx receives SBIR grant to speed up clinical trials for AML and other diseases

Gene discovery in fruit flies could lead to treatments for age-related hearing loss

A new tool to help biomedical scientists better understand COVID-19 virus

AstraZeneca implements Genestack’s flagship Omics Data Manager

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

New project launched to find novel treatments for rare genetic diseases

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

Measuring the binding of SARS-CoV-2 antibodies to the COVID spike protein using SPR

A new therapeutic approach to improve the health of diabetic patients

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

X-ray experiments demonstrate a new way to block the entry of SARS-CoV-2

CELLINK announces partnership with AstraZeneca to provide advanced 3D-bioprinted liver organoids

Study provides new insights on mechanisms that promote cancer

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Event guide: 6th TPD & Induced Proximity Summit Europe eBook

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