Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Study finds altered gut bacteria in people with early signs of Alzheimer's disease

People in the earliest stage of Alzheimer's disease - after brain changes have begun but before cognitive symptoms become apparent - harbor an assortment of bacteria in their intestines that differs from the gut bacteria of healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

14 Jun 2023

Phone menu test assesses daily functioning in people at risk of developing Alzheimer's disease

A new study by investigators from Mass General Brigham has found that a brief, simulated task of navigating a phone menu can detect the earliest changes in daily functioning in people at risk of developing Alzheimer's disease.

14 Jun 2023

Researchers create a diagnostic test to identify functional sperm in infertile men

In a recent study, researchers created a diagnostic test to identify functional sperm in infertile men that could change the treatment of male infertility and assisted reproductive technology.

14 Jun 2023

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Critical Path Institute (C-Path) today announced that the Biomarker Qualification Program (BQP) at the Center for Drug Evaluation and Research (CDER) in the U.S. Food and Drug Administration (FDA) issued a Biomarker Letter of Support (LOS) for four pancreatic injury safety biomarkers identified and evaluated by C-Path's Predictive Safety Testing Consortium's (PSTC) Pancreatic Injury Working Group (PIWG).

14 Jun 2023

Connecting the inflammatory dots: Obesity, depression, and Alzheimer's linked by neuroinflammation

Obesity-induced neuroinflammation significantly contributes to the pathophysiology of depression and Alzheimer's disease. Targeting midlife stage for intervention is crucial to potentially prevent Alzheimer's pathology.

13 Jun 2023

Bergamot fiber shows promise in battling neurodegenerative disorders

Bergamot fiber (BF), a byproduct of citrus fruit processing, shows antioxidant properties and protects against neurotoxicity induced by amyloid beta protein (Aβ), suggesting potential benefits for Alzheimer's disease treatment and waste reduction.

13 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

Rice U. postdoctoral fellow explores the link between menopause and Alzheimer’s disease

Two-thirds of the people suffering from Alzheimer's disease are women, yet most research has ignored differences between the sexes.

12 Jun 2023

Women's use of contraceptive pills linked to greater risk of depression

Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study from Uppsala University. Contraceptive pills increased women's risk by 73 per cent during the first two years of use.

12 Jun 2023

Experimental drug may slow the progression of atherosclerosis

An experimental drug already tested as a potential treatment for cancer, lung disease, and Alzheimer's disease may slow the progression of atherosclerosis that leads to heart disease, a new study shows.

8 Jun 2023

DNAmFitAge: A new method to incorporate physical fitness into epigenetic clocks

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "DNAmFitAge: biological age indicator incorporating physical fitness."

7 Jun 2023

Study identifies new altered neural circuits in Huntington’s disease

Huntington's disease is a genetically-based neurodegenerative disorder that causes motor, cognitive and psychiatric disorders in the affected individuals.

7 Jun 2023

Differences in tumor mutation burden are a major reason for divergence: Study

The expected course of a patient's cancer prognosis has traditionally been judged by its type, stage and microscopic aggressiveness, but patients with the same presentation can still have widely divergent outcomes. Researchers from Vanderbilt-Ingram Cancer Center have discovered that differences in tumor mutation burden are a major reason for this divergence.

7 Jun 2023

New deep learning model lays the foundation for specialized diagnostic models

Mount Sinai researchers have developed an innovative artificial intelligence (AI) model for electrocardiogram (ECG) analysis that allows for the interpretation of ECGs as language. This approach can enhance the accuracy and effectiveness of ECG-related diagnoses, especially for cardiac conditions where limited data is available on which to train.

7 Jun 2023

Two studies seek to understand the drivers of chronic and progressive phase of COVID-19

Early studies of COVID-19 focused on the acute phase of the disease. However, attention has now turned to the long-term consequences of the disease, which are also significant causes of morbidity and mortality.

6 Jun 2023

Fine-tuning cell mechanics stimulates hair growth: Study

Just as people's joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study.

6 Jun 2023

Research sheds new light on the genetic architecture of bipolar disorder

Bipolar disorder (BD) is a major psychiatric condition that afflicts about 1% of people. Symptoms of BD include sudden onset of depressive mood with loss of interest which alternates with a manic state of hyperactivity.

5 Jun 2023

Will a ‘national patient safety board,’ modeled after the NTSB, actually fly?

People concerned about the safety of patients often compare health care to aviation. Why, they ask, can't hospitals learn from medical errors the way airlines learn from plane crashes?

5 Jun 2023

SWOG Cancer Research Network clinical trial reveals potential new therapy for Stage 3 or 4 classic Hodgkin lymphoma

A Phase 3 trial has demonstrated that patients with advanced stage (3 or 4) classic Hodgkin lymphoma who underwent initial treatment with nivolumab, a PD-1 checkpoint inhibitor, and AVD chemotherapy (N-AVD) had a significantly lower risk of their cancer getting worse than patients treated with brentuximab vedotin, a monoclonal antibody, and AVD (BV-AVD) a year after starting treatment.

4 Jun 2023

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Beneath and beyond the reddish, flaky lesions that form in the skin of those with psoriasis, mild and severe forms of the disease can be told apart by the activity of key cells and signaling pathways, a new study shows.

2 Jun 2023

Pathology News and Research

Further Reading

Study finds altered gut bacteria in people with early signs of Alzheimer's disease

Phone menu test assesses daily functioning in people at risk of developing Alzheimer's disease

Researchers create a diagnostic test to identify functional sperm in infertile men

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Connecting the inflammatory dots: Obesity, depression, and Alzheimer's linked by neuroinflammation

Bergamot fiber shows promise in battling neurodegenerative disorders

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

Rice U. postdoctoral fellow explores the link between menopause and Alzheimer’s disease

Women's use of contraceptive pills linked to greater risk of depression

Experimental drug may slow the progression of atherosclerosis

DNAmFitAge: A new method to incorporate physical fitness into epigenetic clocks

Study identifies new altered neural circuits in Huntington’s disease

Differences in tumor mutation burden are a major reason for divergence: Study

New deep learning model lays the foundation for specialized diagnostic models

Two studies seek to understand the drivers of chronic and progressive phase of COVID-19

Fine-tuning cell mechanics stimulates hair growth: Study

Research sheds new light on the genetic architecture of bipolar disorder

Will a ‘national patient safety board,’ modeled after the NTSB, actually fly?

SWOG Cancer Research Network clinical trial reveals potential new therapy for Stage 3 or 4 classic Hodgkin lymphoma

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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