Membrane News and Research

RSS

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

A new study describes the development of new molecules with inhibitory activity against the SARS-CoV-2 viral main protease (Mpro) enzyme, based on rattlesnake venom.

29 Apr 2022

Therapeutic promise of CAR-T cell bispecific engagers against SARS-CoV-2

A new paper describes a novel method, using a specific molecule to engage T cell receptors and the virus receptor, the angiotensin-converting enzyme 2, at the same time.

28 Apr 2022

Study describes ultra-structure of Nipah virus surface glycoprotein

A team of US-based scientists has recently demonstrated the cryo-electron microscopic structure and antigenicity of the attachment glycoprotein of the Nipah virus.

27 Apr 2022

Research helps better understand the biomechanics of human skin

Human skin has evolved to allow maximum durability and flexibility, according to new research from Binghamton University, State University of New York.

27 Apr 2022

New discovery about nature’s ‘high-end machinery’ could have big implications for biology

Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology.

26 Apr 2022

Omicron caused an increase in COVID-19 cases in pregnant women, but less severe illness

Women who were pregnant during the recent Omicron surge were diagnosed with COVID-19 at a much higher rate than during previous phases of the pandemic, but were less likely to develop severe illness, a study by UT Southwestern and Parkland Health scientists found.

26 Apr 2022

UNIGE scientists develop a novel tool to visualize palmitoylation process in living cells

Peripheral membrane proteins have the particularity of temporarily binding to cell membranes, a necessary step for them to be able to fulfil their biological function.

26 Apr 2022

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

Researchers assessed the binding pocket of linoleic acid, an essential free-fatty acid in the receptor-binding domains of the spike protein of beta-coronaviruses.

26 Apr 2022

The response of four SARS-CoV-2 spike variants to linoleic acid removal

A recent paper depicted the differential allosteric response of the SARS-CoV-2 spike variants to linoleic acid.

26 Apr 2022

Quantum dot biomimetic for SARS-CoV-2 examines neurovascular dysregulation related to brain inflammation

Researchers developed SARS-CoV-2 virus-like nanoparticles with a quantum dots core.

26 Apr 2022

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

My work is focused on looking at the dynamics of B/T cell populations within lymph nodes from patients that had recovered from COVID-19. My role in this research was developing and implementing microscopy image analysis techniques using methods and instrumentation in part supplied by TissueGnostics.

From TissueGnostics 26 Apr 2022

The potency of halicin against the main protease of SARS-CoV-2

A new paper published in Current Research in Chemical Biology discusses the potential of a molecule called halicin against SARS-CoV-2.

26 Apr 2022

A novel mouse model to test SARS-CoV-2 viral infection

In a recent study posted to the Research Square* preprint server, researchers developed a novel mouse model for testing infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

26 Apr 2022

Scientists show how T cells may help protect against severe COVID

In a recent study published in the Clinical Infectious Diseases journal, the researchers summarized the perspectives and observations on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related adaptive immunity.

25 Apr 2022

Study reports increased numbers of SARS-CoV-2-reactive T cells in individuals who were HCoV-reactive

T cell responses were measured to three SARS-CoV-2-associated antigens, as well as the endemic coronaviruses HCoV-OC43 and HCoV-NL63.

25 Apr 2022

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

For more than two decades, University of Alabama at Birmingham researcher Susan Bellis, Ph.D., has studied how the addition of sialic acid to various proteins increases cancer resistance and oncogenicity.

22 Apr 2022

Interleukin-6 levels predict early withdrawal of COVID-19 patients from mechanical ventilation

Researchers reported that plasma IL-6 levels in patients with ARDS due to COVID-19 could predict early withdrawal from mechanical ventilation.

22 Apr 2022

Study suggests SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level

Researchers demonstrated SARS-CoV-2 evolution at the transcriptional level.

22 Apr 2022

SARS-CoV-2 spike protein disrupts lipid metabolism resulting in liver, heart & kidney damage

A new study describes the impact of SARS-CoV-2 on host lipid metabolism.

21 Apr 2022

New insight into SARS-CoV-2 main protease opens door to new viral inhibitors

A recent study has revealed a full cycle of substrate cleavage for the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – providing, in turn, a steadfast foundation for developing potent new viral inhibitors. The paper was published in the journal Proceedings of the National Academy of Sciences (PNAS).

20 Apr 2022

Membrane News and Research

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

Therapeutic promise of CAR-T cell bispecific engagers against SARS-CoV-2

Study describes ultra-structure of Nipah virus surface glycoprotein

Research helps better understand the biomechanics of human skin

New discovery about nature’s ‘high-end machinery’ could have big implications for biology

Omicron caused an increase in COVID-19 cases in pregnant women, but less severe illness

UNIGE scientists develop a novel tool to visualize palmitoylation process in living cells

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

The response of four SARS-CoV-2 spike variants to linoleic acid removal

Quantum dot biomimetic for SARS-CoV-2 examines neurovascular dysregulation related to brain inflammation

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

The potency of halicin against the main protease of SARS-CoV-2

A novel mouse model to test SARS-CoV-2 viral infection

Scientists show how T cells may help protect against severe COVID

Study reports increased numbers of SARS-CoV-2-reactive T cells in individuals who were HCoV-reactive

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

Interleukin-6 levels predict early withdrawal of COVID-19 patients from mechanical ventilation

Study suggests SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level

SARS-CoV-2 spike protein disrupts lipid metabolism resulting in liver, heart & kidney damage

New insight into SARS-CoV-2 main protease opens door to new viral inhibitors

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo