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Modified Vaccinia Ankara model vaccine prevents COVID-19 in transgenic mice study

A new study shows the effectiveness of a novel recombinant vaccinia virus that expresses modified SARS-CoV-2 spike antigen, in preventing the replication of the virus in the respiratory tract of transgenic mice, and to prevent lethal disease.

6 Jan 2021

Liver cancer cells cause stromal cells to secrete protein that enhances tumor growth

Hepatocellular carcinoma (HCC), frequently seen in patients with liver cirrhosis caused by alcohol abuse or chronic viral hepatitis, is the most common form of liver cancer worldwide.

6 Jan 2021

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue.

5 Jan 2021

Researchers develop α-emitting cancer therapy using a novel drug targeting LAT1

A cancer-specific L-type amino acid transporter 1 (LAT1) is highly expressed in cancer tissues.

4 Jan 2021

Large transporter protein dysfunction associated with schizophrenia

Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens.

29 Dec 2020

Gut cells alert the body to danger during parasite invasion

To effectively combat an infection, the body first has to sense it's been invaded, then the affected tissue must send out signals to corral resources to fight the intruder.

28 Dec 2020

Researchers find mechanism underlying plasticity in adult brains

Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away.

24 Dec 2020

Study presents novel gene therapy for deafness

A new study from Tel Aviv University presents an innovative treatment for deafness, based on the delivery of genetic material into the cells of the inner ear.

23 Dec 2020

Study provides new insights into the molecular underpinnings of Duchenne muscular dystrophy

A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchene muscular dystrophy (DMD) in humans.

21 Dec 2020

Researchers demonstrate potential preventive treatment for Crohn's disease

A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease.

21 Dec 2020

Moffitt study may lead to potential treatment options for cutaneous T cell lymphoma

Cutaneous T cell lymphomas (CTCLs) are a group of non-Hodgkin lymphomas that develop from T cells and mainly impact the skin with painful lesions.

21 Dec 2020

Arthritis drug may be effective in treating immunotherapy-related heart complication

A drug typically prescribed for rheumatoid arthritis may also be effective in treating a rare but potentially deadly heart complication some cancer patients experience after taking immunotherapies, according to a study published in Cancer Discovery and co-led by investigators at Vanderbilt University Medical Center.

21 Dec 2020

Study finds how macrophages may contribute to a therapeutic weak spot in breast cancer

Breast cancer, the second most common cancer in the United States, can result from a number of cellular misregulations, such as deficiencies in the DNA-repairing breast cancer gene, BRCA.

18 Dec 2020

Research examines processes of lung scarring and chronic rejection of organ after transplantation

Two new papers examine the processes of lung scarring and chronic rejection of the organ after transplantation, and potential therapies to stop the graft, or transplanted organ and its tissue, from failing.

17 Dec 2020

Study: Specific class of drugs can be repurposed to treat genetic diseases

Researchers at the University of Illinois Chicago have published a study showing a promising approach to using drug repurposing to treat genetic diseases.

17 Dec 2020

Study shows an inflammatory response in the mice brain is responsible for severe COVID-19

Researchers demonstrated that neuroinvasion and encephalitis caused by SARS-CoV-2 is associated with significant mortality in a special mouse model.

17 Dec 2020

Researchers use new method to deliver anti-cancer drug to suppress tumor growth

Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory ability.

17 Dec 2020

Mouse Model News and Research

Modified Vaccinia Ankara model vaccine prevents COVID-19 in transgenic mice study

Liver cancer cells cause stromal cells to secrete protein that enhances tumor growth

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Researchers develop α-emitting cancer therapy using a novel drug targeting LAT1

Large transporter protein dysfunction associated with schizophrenia

Gut cells alert the body to danger during parasite invasion

Researchers find mechanism underlying plasticity in adult brains

Study presents novel gene therapy for deafness

Study provides new insights into the molecular underpinnings of Duchenne muscular dystrophy

Researchers demonstrate potential preventive treatment for Crohn's disease

Moffitt study may lead to potential treatment options for cutaneous T cell lymphoma

Arthritis drug may be effective in treating immunotherapy-related heart complication

Study finds how macrophages may contribute to a therapeutic weak spot in breast cancer

Research examines processes of lung scarring and chronic rejection of organ after transplantation

Study: Specific class of drugs can be repurposed to treat genetic diseases

Study shows an inflammatory response in the mice brain is responsible for severe COVID-19

Researchers use new method to deliver anti-cancer drug to suppress tumor growth

Researchers use bacterial strains to measure host gene expression in mouse model

Scientists demonstrate a promising strategy for treating lymphomas

NET study: New theranostic approach effective in reducing tumor volume and extending lifespan

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