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Phase 1/2 trial results for Nanocovax, protein subunit SARS-CoV-2 vaccine from Vietnam

Nanocovax is a protein subunit vaccine that contains the full-length spike stabilized by the addition of two prolines

29 Jul 2021

Systematic review explores the effects of ivermectin in preventing and treating COVID-19

Ivermectin, a drug used to treat parasites such as scabies in humans and intestinal helminths in cattle, was screened in 2020 for activity against COVID-19. Laboratory tests suggested a weak effect on SARS-CoV-2 virus in a test tube but did not seem feasible in humans as the doses needed would be large.

28 Jul 2021

Women say California insurer makes it too hard to get drug for postpartum depression

When Miriam McDonald decided she wanted to have another baby at age 44, her doctor told her she had a better chance of winning the lottery. So when she got pregnant right away, she and her husband were thrilled. But within three days of giving birth to their son, in September 2019, everything shifted.

28 Jul 2021

Study clarifies the benefits of neurofeedback for children with ADHD

The economic burden of providing special education and training for a child diagnosed with ADHD (attention-deficit/hyperactivity disorder) is estimated to cost the average American family five times as much as a child without ADHD.

27 Jul 2021

Investigational antipsychotic treatment offers sustained benefits for people with dementia-related psychosis

Evidence of the sustained benefits of an investigational antipsychotic treatment for people with dementia-related psychosis has been published.

22 Jul 2021

Use of topical fluorides for caries prevention in primary teeth

Alexandria, Va., USA - Parach Sirivichayakul, Mahidol University, Bangkok, Thailand, presented the poster "Preventing Approximal Caries in Primary Teeth With Topical Fluorides" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.

22 Jul 2021

Clinical trial to test personalized treatment for severe asthma caused by a specific mutation

Under a $10 million grant, a randomized, placebo-controlled clinical trial led by Boston Children's Hospital will test a personalized treatment for a form of severe asthma to which Black and Latinx children and adults are especially vulnerable.

21 Jul 2021

Analysis: Necessary or not, covid booster shots are probably on the horizon

The drugmaker Pfizer recently announced that vaccinated people are likely to need a booster shot to be effectively protected against new variants of covid-19 and that the company would apply for Food and Drug Administration emergency use authorization for the shot.

21 Jul 2021

New research may offer clues to why MS patients develop progressive disability

Did you know multiple sclerosis (MS) means multiple scars? New research shows that the brain and spinal cord scars in people with MS may offer clues to why they developprogressive disability but those with related diseases where the immune system attacks the central nervous system do not.

19 Jul 2021

Patient's case report reveals link between Bell’s palsy and Pfizer-BioNTech vaccine

The case of a patient who experienced two facial palsies – one after the first and another after the second dose of the Pfizer-BioNTech COVID-19 vaccine – strongly suggests that Bell’s palsy (facial nerve palsy of unknown cause) is linked to the Pfizer-BioNTech vaccine, doctors write in the journal BMJ Case Reports.

19 Jul 2021

Broad-spectrum antibiotic no more effective than placebo in preventing COVID-19 symptoms

A UC San Francisco study has found that the antibiotic azithromycin was no more effective than a placebo in preventing symptoms of COVID-19 among non-hospitalized patients, and may increase their chance of hospitalization, despite widespread prescription of the antibiotic for the disease.

16 Jul 2021

Excess caffeine intake may be linked to increased risk of osteoporosis

University of South Australia researchers have a bone to pick when it comes to drinking too much coffee as new research finds that excess caffeine may be linked to an increased risk of osteoporosis.

16 Jul 2021

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

Researchers in the United States have designed a modular protein subunit vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited a strong immune response in macaques and prevented the animals from developing coronavirus disease 2019 (COVID-19).

15 Jul 2021

Why we may never know whether the $56,000-a-year Alzheimer’s drug actually works

The Food and Drug Administration's approval in June of a drug purporting to slow the progression of Alzheimer's disease was widely celebrated, but it also touched off alarms.

12 Jul 2021

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

Scientists from the US and Germany have recently evaluated the efficacy of an mRNA-based COVID-19 vaccine candidate, CV07050101, in inducing humoral and cellular immune responses in non-human primates. The study reveals that prime-boost immunization with the vaccine candidate induces only limited immunity against SARS-CoV-2.

12 Jul 2021

What is behind the inconsistent results of COVID-19 clinical trials?

“Most clinical studies of antiviral drugs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have failed to observe a statistically significant effect, which may be due to poor designs of clinical trials.”

12 Jul 2021

Durable antibody response at least 8 months following vaccination with J&J COVID vaccine

A recent study by a team of scientists at Beth Israel Deaconess Medical Center and Janssen Vaccines & Prevention has demonstrated that humoral and cellular immunity elicited by the coronavirus disease 2019 (COVID-19) vaccine Ad26.COV2.S remains active for at least eight months.

9 Jul 2021

Common orthopedic procedures lack high quality evidence, analysis reveals

Most common bone and joint procedures, such hip replacements and shoulder repair surgery, are not backed up by high quality evidence, mainly because of a lack of definitive trials, suggests an analysis of data published by The BMJ today.

8 Jul 2021

New analysis finds muscle relaxant drugs to be largely ineffective for low back pain

Muscle relaxant drugs are largely ineffective for low back pain, despite being widely prescribed for this condition, suggests an analysis of the latest evidence published by The BMJ today.

8 Jul 2021

Interleukin-6 antagonists benefit hospitalized patients with COVID-19

Findings from a study published today [6 July] in the Journal of the American Medical Association (JAMA) have prompted new World Health Organization (WHO) recommendations to use interleukin-6 antagonists in patients with severe or critical COVID-19 along with corticosteroids.

7 Jul 2021

Placebo News and Research

Phase 1/2 trial results for Nanocovax, protein subunit SARS-CoV-2 vaccine from Vietnam

Systematic review explores the effects of ivermectin in preventing and treating COVID-19

Women say California insurer makes it too hard to get drug for postpartum depression

Study clarifies the benefits of neurofeedback for children with ADHD

Investigational antipsychotic treatment offers sustained benefits for people with dementia-related psychosis

Use of topical fluorides for caries prevention in primary teeth

Clinical trial to test personalized treatment for severe asthma caused by a specific mutation

Analysis: Necessary or not, covid booster shots are probably on the horizon

New research may offer clues to why MS patients develop progressive disability

Patient's case report reveals link between Bell’s palsy and Pfizer-BioNTech vaccine

Broad-spectrum antibiotic no more effective than placebo in preventing COVID-19 symptoms

Excess caffeine intake may be linked to increased risk of osteoporosis

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

Why we may never know whether the $56,000-a-year Alzheimer’s drug actually works

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

What is behind the inconsistent results of COVID-19 clinical trials?

Durable antibody response at least 8 months following vaccination with J&J COVID vaccine

Common orthopedic procedures lack high quality evidence, analysis reveals

New analysis finds muscle relaxant drugs to be largely ineffective for low back pain

Interleukin-6 antagonists benefit hospitalized patients with COVID-19

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Evaluating new approaches for rare disease genomics

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