Preclinical News and Research

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Nanotechnology's triple threat: Advancing precision cancer treatment

The design of tumor tissue-, cell-, and organelle-targeted cancer nanomedicines.

9 Aug 2023

The immune-modulatory effect of lenvatinib investigated in new study

Researchers explore the effect of lenvatinib treatment on patients with advanced thyroid cancer.

9 Aug 2023

Sugar-sweetened beverages linked to increased risk of liver cancer and chronic liver disease mortality

Approximately 65% of adults in the United States consume sugar sweetened beverages daily. Chronic liver disease is a major cause of morbidity and mortality worldwide and can result in liver cancer and liver disease-related mortality.

8 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Identification of plasma proteins associated with ovarian cancer risk

Researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.

8 Aug 2023

New antibody shows promise in reversing carfentanil overdoses

An antibody in single-chain fragment variable (scFv) format that binds to the powerful opioid carfentanil was shown to reverse signs of carfentanil overdose in preclinical tests conducted by scientists at Scripps Research.

7 Aug 2023

Adjuvanted intranasal vaccine shows promise for long-lasting immunity to COVID-19

While much of the global concern has subsided, COVID-19 is still a very real threat, especially to people with compromised immune systems or who are over 65.

7 Aug 2023

Metrion Biosciences announces launch of Good Laboratory Practice (GLP) hERG Screening Service

Metrion Biosciences Limited, the specialist ion channel contract research and drug discovery company, today announced it has received notification from the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) that the Company is now a member of the UK GLP (Good Laboratory Practice) Compliance Monitoring Programme, and is, therefore, able to offer GLP compliant hERG ion channel screening services to the global life sciences community.

From Metrion Biosciences Limited 7 Aug 2023

How do dietary patterns influence inflammatory bowel disease?

Researchers used bibliometrics to analyze studies describing the effects of dietary patterns on inflammatory bowel disease (IBD).

7 Aug 2023

Neoantigen discovery sheds light on cancer immunogenicity

Researchers reported a proteogenomic approach to investigate fresh solid melanoma tumor material.

4 Aug 2023

GABA-modulating treatments could help tackle cognitive, affective symptoms associated with depression

Depression is a complex condition correlated with multiple differences in brain function and mechanisms. A new paper spanning known data about the neurotransmitter GABA and its principal receptors showcases evidence of the receptors' importance in depression and potential as therapeutic targets.

3 Aug 2023

Gut microbiome changes have significant effects on cocaine use and cravings

According to the 2021 National Survey on Drug Use and Health, 4.8 million people (ages 12 and up) reported using cocaine within the previous 12 months, and 24,486 people died from an overdose involving cocaine.

3 Aug 2023

NIH awards $18 million to develop novel chikungunya vaccine

The Access to Advanced Health Institute (AAHI) announced today that it has received an $18 million award from the National Institutes of Health (NIH) to develop a temperature stable, single-dose vaccine candidate for the chikungunya virus.

3 Aug 2023

UC San Diego team reports new insights on pelvic floor muscle dysfunction

University of California San Diego researchers are leading a team reporting new insights in Science Translational Medicine on pelvic floor muscle (PFM) dysfunction, which is one of the key risk factors for pelvic floor disorders which impact close to a quarter of women in the U.S.

2 Aug 2023

New drug shows promise for treating chronic neuropathic pain

A non-opioid designer molecule for treating chronic neuropathic pain by calming hyperactive pain-sensing neurons in the peripheral nervous system has had promising results in a preclinical study conducted by researchers at Weill Cornell Medicine and the Burke Neurological Institute.

2 Aug 2023

New drug targets EMT in cancer, reducing metastasis and resistance to chemotherapy

Metastases and resistance to chemotherapy are the main causes of treatment failure and mortality in cancer patients.

2 Aug 2023

Review studies relationships between vitamin E intake or circulating α-tocopherol and various health outcomes

In a recent study, researchers examined the relationships between vitamin E or circulating α-tocopherol intake and health outcomes using a meta-analyses.

2 Aug 2023

MGH opens first-of-its-kind center to eliminate lifelong immunosuppression after organ transplant

Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham health system, officially opened the Legorreta Center for Clinical Transplant Tolerance, the first-of-its kind center in the world dedicated to preventing organ rejection after transplant surgery without the use of lifelong immunosuppressive medications.

1 Aug 2023

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research.

1 Aug 2023

IN8bio opens new cancer research lab in Birmingham's Pepper Place

Birmingham's Pepper Place has a striking new addition to its teeming farmers' market and noted food offerings - a multimillion-dollar cancer research laboratory.

1 Aug 2023

Preclinical News and Research

Nanotechnology's triple threat: Advancing precision cancer treatment

The immune-modulatory effect of lenvatinib investigated in new study

Sugar-sweetened beverages linked to increased risk of liver cancer and chronic liver disease mortality

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Identification of plasma proteins associated with ovarian cancer risk

New antibody shows promise in reversing carfentanil overdoses

Adjuvanted intranasal vaccine shows promise for long-lasting immunity to COVID-19

Metrion Biosciences announces launch of Good Laboratory Practice (GLP) hERG Screening Service

How do dietary patterns influence inflammatory bowel disease?

Neoantigen discovery sheds light on cancer immunogenicity

GABA-modulating treatments could help tackle cognitive, affective symptoms associated with depression

Gut microbiome changes have significant effects on cocaine use and cravings

NIH awards $18 million to develop novel chikungunya vaccine

UC San Diego team reports new insights on pelvic floor muscle dysfunction

New drug shows promise for treating chronic neuropathic pain

New drug targets EMT in cancer, reducing metastasis and resistance to chemotherapy

Review studies relationships between vitamin E intake or circulating α-tocopherol and various health outcomes

MGH opens first-of-its-kind center to eliminate lifelong immunosuppression after organ transplant

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

IN8bio opens new cancer research lab in Birmingham's Pepper Place

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics