Proliferation News and Research

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Potential drug treatment for AXL-low expressing EGFR-mutated lung cancer

Researchers at Kanazawa University report in Nature Communications the mechanism making some lung-cancer patients resistant to the drug osimertinib.

5 Oct 2020

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Using ELISpot and proliferation assays, researchers show strong responses in SARS-CoV-2 infected patients, but not so much in negative samples. However, there may be cross-reactive T cell responses from other human coronaviruses.

5 Oct 2020

Lung tissue in fatal COVID-19 shows broad cell tropism and extensive damage

In a recent preprint paper published on the medRxiv server, researchers demonstrated their investigation of fatal COVID-19 patients to assess infection in various cell types and the extent of damage it caused to the lung tissues.

30 Sep 2020

Scientists identify key molecules that mediate radioresistance in aggressive brain cancer

Scientists have identified key molecules that mediate radioresistance in glioblastoma multiforme; these molecules are a potential target for the treatment of this brain cancer.

30 Sep 2020

FUJIFILM Irvine Scientific to exclusively distribute chemically defined substrate for stem cell culture

FUJIFILM Irvine Scientific today announced that it has become the exclusive, worldwide distributor of cellnest®, a recombinant peptide attachment substrate.

From FUJIFILM Irvine Scientific 30 Sep 2020

Researchers report promising preclinical findings for a prototype of vascular graft

In a proof-of-concept study, North Carolina State University researchers reported promising preclinical findings for a prototype of a vascular graft designed as a replacement for a damaged or blocked coronary artery, which supplies blood to the heart.

30 Sep 2020

Induction of acute senescence may be a necessary process in hemorrhagic shock

It's called senescence, when stressed cells can no longer divide to make new cells, and it's considered a factor in aging and in some diseases.

29 Sep 2020

Study finds link between screen time, dietary patterns and various health behaviors

The era of the television brought with it the TV dinner -- a fast, convenient meal that, while nutritionally questionable, meant the whole family could gather together on the sofa to enjoy "The Ed Sullivan Show" and eat their Swanson Salisbury steak, too.

28 Sep 2020

Research says in SARS-CoV-2 canine infection, transmission unlikely

A new study published on the preprint server bioRxiv* in September 2020 shows that pet dogs have been falling sick and dying of a mysterious respiratory infection, often showing the presence of anti- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, even though in many cases they do not test positive for COVID-19.

24 Sep 2020

Molecular insights may foster effective therapies for COVID-19 patients

Viral and bacterial pathogens wield pathogenic or virulent proteins that interact with high-value targets inside human cells, attacking what is known as the host interactome. The host interactome is the network map of all the protein-protein interactions inside cells.

24 Sep 2020

Polyphenolic compound offers new therapeutic option for chronic inflammatory disorders

Various plants and their products are known to contain "bioactive" ingredients that can alleviate human diseases. These "phytocompounds" often contain restorative biological properties such as anti-cancerous, antioxidant, and anti-inflammatory effects.

24 Sep 2020

Study reveals how loss of protein arginine methyltransferase affects proper brain development

Normal brain development requires a precise interplay between neuronal and non-neuronal (also called glial) cells.

24 Sep 2020

Study: R-spondin growth factor reduces intestinal tumors in early phase of colorectal cancer

Colorectal cancer constitute the third most common cancer in the Western world. Their incidence constantly increases as the population ages, and despite recent advances in colorectal cancer therapy, the cancer metastasizes in every third of colorectal cancer patients, and a significant part of these patients eventually die from the disease

24 Sep 2020

Researchers identify a compound that inhibits growth of schwannomas

Schwannomas are tumors of the peripheral nervous system, which often occur in the genetic disease neurofibromatosis type 2. The research group of Prof. Dr. Helen Morrison at the Leibniz Institute on Aging - Fritz Lipmann Institute in Jena, Germany, identified a compound that inhibits the growth of such tumors and improves nerve function.

21 Sep 2020

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical benefits.

21 Sep 2020

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, according to results from a study at ESMO 2020.

21 Sep 2020

Combined use of three drugs linked with lower lung cancer incidence and mortality

Combined use of aspirin, statins, and metformin is associated with decreased lung cancer incidence and mortality, according to a study published in the Journal of Thoracic Oncology.

17 Sep 2020

Higher viral loads can increase mortality rate in patients hospitalized with COVID-19 and cancer

Higher viral loads are associated with a greater risk of death among cancer and non-cancer patients hospitalized with coronavirus disease 2019 (COVID-19), researchers report September 15 in the journal Cancer Cell.

17 Sep 2020

Candidate monoclonal antibody shows hope as COVID-19 treatment

Researchers in the United States have described the effectiveness of a candidate monoclonal antibody currently being evaluated in a Phase 1 trial as a therapy for coronavirus disease 2019 (COVID-19) and its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Sep 2020

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Now, a study by researchers from the University of California has shown that the N protein forms biomolecular condensates with the viral RNA in both in vitro and in vivo studies. The research titled, ‘SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA’, was published on the preprint server bioRxiv on September 14th, 2020.

15 Sep 2020

Proliferation News and Research

Potential drug treatment for AXL-low expressing EGFR-mutated lung cancer

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Lung tissue in fatal COVID-19 shows broad cell tropism and extensive damage

Scientists identify key molecules that mediate radioresistance in aggressive brain cancer

FUJIFILM Irvine Scientific to exclusively distribute chemically defined substrate for stem cell culture

Researchers report promising preclinical findings for a prototype of vascular graft

Induction of acute senescence may be a necessary process in hemorrhagic shock

Study finds link between screen time, dietary patterns and various health behaviors

Research says in SARS-CoV-2 canine infection, transmission unlikely

Molecular insights may foster effective therapies for COVID-19 patients

Polyphenolic compound offers new therapeutic option for chronic inflammatory disorders

Study reveals how loss of protein arginine methyltransferase affects proper brain development

Study: R-spondin growth factor reduces intestinal tumors in early phase of colorectal cancer

Researchers identify a compound that inhibits growth of schwannomas

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Combined use of three drugs linked with lower lung cancer incidence and mortality

Higher viral loads can increase mortality rate in patients hospitalized with COVID-19 and cancer

Candidate monoclonal antibody shows hope as COVID-19 treatment

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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