Efficacy News and Research

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Obe-cel demonstrates strong efficacy and safety in treating leukemia

Patients with relapsed or refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) who were treated with the novel anti-CD19 chimeric antigen receptor (CAR) T cell therapy, obecabtagene autoleucel (obe-cel), experienced high response rates and most did not need a subsequent stem cell transplant (SCT), according to results from the Phase Ib/II FELIX trial co-led by researchers at The University of Texas MD Anderson Cancer Center.

27 Nov 2024

New HIV prevention injection offers 96% protection

For oral medications that prevent new HIV infection to be effective, the patient must take certain actions, including attending doctor's visits every three months and – most importantly – consistency.

27 Nov 2024

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

27 Nov 2024

SONIA trial demonstrates cost-effective treatment approach for advanced breast cancer

On November 27, the prestigious journal Nature will publish the results of an innovative breast cancer research project from the Netherlands.

27 Nov 2024

Novel mRNA-based therapy offers hope for patients with proliferative vitreoretinopathy

A new preclinical study by Mass Eye and Ear investigators showed that a novel mRNA-based therapy may be able to prevent blindness and scarring from proliferative vitreoretinopathy (PVR) following a retinal detachment repair or traumatic injury to the eye.

27 Nov 2024

New gold-based drug proves to be more potent than standard chemotherapy

A new gold-based drug can slow tumour growth in animals by 82% and target cancers more selectively than standard chemotherapy drugs, according to a study by Australian and Indian researchers.

27 Nov 2024

Cryoablation for PFO closure in AF patients undergoing PVI

New research shows that cryoablation is a safe and effective approach to close congenital patent foramen ovale (PFO, a small hole in the heart) in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI) in a single procedure.

27 Nov 2024

Late-liver-stage malaria vaccine delivers 89% protection and boosts cellular immunity

Genetically attenuated malaria parasites with extended liver-stage arrest (GA2) showed 89% protection in a clinical trial, surpassing earlier vaccine candidates and highlighting the potential of cellular immunity.

26 Nov 2024

Machine learning tool detects early signs of Alzheimer's in mice

Subtle signs of Alzheimer's disease can emerge decades before a diagnosis - often in the form of irregular behaviors that reflect very early stages of brain dysfunction.

26 Nov 2024

Study unlocks the secrets of beta cell regeneration

Prof. Heiko Lickert is the director of the Institute of Diabetes and Regeneration Research at Helmholtz Munich, professor at the Technical University of Munich (TUM), and member of the German Center for Diabetes Research (DZD).

26 Nov 2024

Protein-based gel offers sustainable solution for personal skincare products

If you have a meticulous skincare routine, you know that personal skincare products (PSCPs) are a big business.

25 Nov 2024

New therapy from UI Health becomes the first FDA-approved treatment for brittle type 1 diabetes

A new therapy for brittle type 1 diabetes, the only treatment currently approved by the U.S. Food and Drug Administration, is available exclusively at UI Health in Chicago.

25 Nov 2024

New AI model tailors phage treatment for resistant bacterial infections

With the rapid development of antibiotics in the 1930s, phage therapy – using viruses known as bacteriophages or phages to tackle bacterial infections – fell into oblivion.

25 Nov 2024

How breast cancer patients respond to tamoxifen may be linked to the gut microbiome

A new study has shown that variation in the microbiota of the human gut impacts the pharmacokinetics of tamoxifen and thus the effectiveness of the drug.

25 Nov 2024

Steritas announces collaboration with argenx to advance evidence for novel steroid-sparing therapeutics

Steritas LLC., a company dedicated to enhancing care for steroid-treated patients, today announced a licensing agreement with argenx, a global immunology company, for use of its STOX® Suite of steroid-toxicity clinical outcome assessments (COAs) across argenx's development programs for differentiated immunology therapeutics.

From Steritas LLC 25 Nov 2024

Framing chores as learning opportunities encourages child autonomy, study shows

Parents are much less likely to intervene when their young children are getting dressed or performing other simple chores if those tasks are framed as learning opportunities, according to a new study by Yale researchers.

23 Nov 2024

AI-designed drug ISM5939 granted IND clearance for cancer clinical trials

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announced that it has received IND clearance from FDA for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the treatment of solid tumors.

22 Nov 2024