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NIH scientists identify genomic variants that cause rare inflammatory skin disorder

Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.

31 May 2023

Wastewater data unveils underreported Mpox cases in Texas

A recent study characterizes the analytical sensitivity of three assays used to detect MPXV in wastewater samples.

31 May 2023

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Researchers from Children's Hospital of Philadelphia, the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the Children's Brain Tumor Network, the Pacific Pediatric Neuro-Oncology Consortium, and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors.

31 May 2023

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Melatonin, a hormone derived from the pineal gland, has diverse effects on cellular processes. This review explores its potential role as an epigenetic regulator, particularly in modulating DNA methylation, and suggests its use in combination therapy as a novel anticancer strategy.

30 May 2023

Computational approach could help pinpoint causal variants in the noncoding genome

Less than two percent of the human genome codes for proteins, with the rest being noncoding and likely helping with gene regulation.

30 May 2023

Researchers find oldest evidence of the plague in Britain to date

Researchers at the Francis Crick Institute have identified three 4,000-year-old British cases of Yersinia pestis, the bacteria causing the plague – the oldest evidence of the plague in Britain to date, reported in a paper published today in Nature Communications.

30 May 2023

New pan-cancer T cell atlas provides a deeper understanding of complex tumor microenvironment

A new study led by researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Medicine, provides a deeper understanding of the vast diversity of T cell states as well as their relationships and roles within the complex tumor microenvironment, bringing a fresh perspective to understanding immunotherapy efficacy in cancer.

29 May 2023

Two bacteria that co-occur with C. difficile as emerging potential threats in planetary health

A new study published in the peer-reviewed OMICS: A Journal of Integrative Biology identified genes for virulence and antimicrobial resistance in two bacteria that co-occur with C. difficile, suggesting these pathogens as emerging potential threats in planetary health.

26 May 2023

Groundbreaking study targets 'jumping genes' in the entire genomes of the human large intestine

The Korea Advanced Institute of Science and Technology (KAIST) and their collaborators have conducted a groundbreaking study targeting 'jumping genes' in the entire genomes of the human large intestine.

25 May 2023

Identifying what makes some gut bacteria strains life-threatening in pre-term babies

Researchers from the Quadram Institute and University of East Anglia have identified what makes some strains of gut bacteria life-threatening in pre-term babies.

25 May 2023

Statistical modeling based of Australian native possum excreta identifies locations of Buruli ulcer occurrence in humans

The study aimed to predict the future human Buruli ulcer case locations via statistical modelling.

25 May 2023

CDC reports on its Mpox response

Research paper provides an overview of the U.S. monkeypox outbreak, highlighting the rapid response, vaccination efforts, and racial disparities in cases. Ongoing surveillance, vaccination, and communication are emphasized as crucial for future prevention.

24 May 2023

WHO chief: World must prepare for deadlier outbreak than COVID-19

The world should be prepared to respond to a disease outbreak of "even deadlier potential" than COVID-19, the head of the WHO said after the UN agency launched a global network to monitor disease threats.

23 May 2023

Scientists to discuss the latest cancer therapies, advances in PSMA PET scans and many more at ASCO

Physicians and scientists from the UCLA Jonsson Comprehensive Cancer Center will discuss the latest research and clinical trial results on combination therapies for breast cancer, a potential new treatment for patients with recurrent glioma, and advances in PSMA PET guided radiotherapy for patients with prostate cancer, among other topics, at the American Society of Clinical Oncology's annual meeting.

23 May 2023

High HDL-C levels and cardiovascular risks - what you need to know!

Research paper investigates the relationship between very high levels of high-density lipoprotein cholesterol (HDL-C) and cardiovascular outcomes in the general population. The study reveals that while men with high HDL-C face an increased risk of all-cause death and cardiovascular death, this association is not observed in women without coronary artery disease.

22 May 2023

Newly developed method can help identify the special differences in genetic information

Plants show enormous variety in traits relevant to breeding, such as plant height, yield and resistance to pests.

22 May 2023

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage - a cause and consequence of many diseases.

22 May 2023

Genetic insights unveil promising therapeutic targets for critical COVID-19

Critical COVID-19 illness reveals genetic associations with immunomodulatory therapies, as identified in a comprehensive analysis of 24,202 cases. This study uncovers novel genome-wide significant associations, highlighting potential druggable targets for inflammatory signaling, immunometabolism, and viral replication, offering insights into therapeutic implications.

21 May 2023

Genomes of modern humans shaped by admixture events

The course of human history has been marked by complex patterns of migration, isolation, and admixture, the latter a term that refers to gene flow between individuals from different populations.

19 May 2023

Research findings bring order to the genomic chaos of ovarian high grade serous carcinoma

New research findings based on the evolution of malignant tumors increase our understanding of the characteristics of an ovarian cancer subtype that is difficult to treat.

19 May 2023

Genomic News and Research

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

Wastewater data unveils underreported Mpox cases in Texas

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Computational approach could help pinpoint causal variants in the noncoding genome

Researchers find oldest evidence of the plague in Britain to date

New pan-cancer T cell atlas provides a deeper understanding of complex tumor microenvironment

Two bacteria that co-occur with C. difficile as emerging potential threats in planetary health

Groundbreaking study targets 'jumping genes' in the entire genomes of the human large intestine

Identifying what makes some gut bacteria strains life-threatening in pre-term babies

Statistical modeling based of Australian native possum excreta identifies locations of Buruli ulcer occurrence in humans

CDC reports on its Mpox response

WHO chief: World must prepare for deadlier outbreak than COVID-19

Scientists to discuss the latest cancer therapies, advances in PSMA PET scans and many more at ASCO

High HDL-C levels and cardiovascular risks - what you need to know!

Newly developed method can help identify the special differences in genetic information

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Genetic insights unveil promising therapeutic targets for critical COVID-19

Genomes of modern humans shaped by admixture events

Research findings bring order to the genomic chaos of ovarian high grade serous carcinoma

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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