Lymph Node News and Research

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Lymph is clear or white fluid that travels through vessels, moves within tissues and work to keep all the parts of the body clean. After passing through the channels of the lymphatic system they drain into the lymph nodes. The lymph nodes act as filters along the lymphatic system. These nodes trap germs like bacteria, viruses, toxins as well as cancer cells and ensure that these are removed from the body.

Cancer immunotherapies can become more potent depending on the time of day

Scientists from the UNIGE and LMU show that the anti-tumor activity of the immune system - and the effectiveness of cancer immunotherapies - depends on the time of day.

7 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

New ASTRO guideline provides recommendations on the use of radiation therapy for endometrial cancer

A newly updated clinical guideline from the American Society for Radiation Oncology provides recommendations on the use of radiation therapy and systemic therapy after surgery to treat patients with endometrial cancer.

7 Dec 2022

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Among premenopausal women with hormone receptor (HR)-positive, early-stage breast cancer enrolled in the SOFT trial, those with a high score on a genomic assay called Breast Cancer Index (BCI) had increased risk of distant recurrence, and those with low BCI benefited more from the addition of ovarian suppression therapy to endocrine therapy after 12 years of follow-up, according to data presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Air pollution-triggered immune surveillance deficits in the lungs increase the risk of respiratory diseases with aging

Researchers highlighted the significance of air quality in preserving immune health over the human lifespan, especially lung-related immunity, owing to the lungs' continuous exposure to the environment.

7 Dec 2022

The impact of Pfizer‐BioNTech’s BNT162b2 mRNA vaccine booster on the maximum oxygen uptake capacity among recreational endurance athletes

Researchers evaluated the impact of Pfizer‐BioNTech’s BNT162b2 mRNA vaccine booster on the maximum oxygen uptake capacity (VO2max) among recreational endurance athletes.

29 Nov 2022

Researchers develop a new method to map the spatial evolution of cancers

Researchers developed a genetic clone mapping workflow centered around base-specific in situ sequencing (BaSISS) technology to derive quantitative maps of multiple genetic clones of cancer cells.

11 Nov 2022

Study shows benefits of metastasis-directed therapy without ADT for oligorecurrent prostate cancer

For patients with solitary metastases from prostate cancer, an approach called metastasis-directed therapy (MDT) – focused treatment using surgery or radiation therapy, without androgen deprivation therapy (ADT) – can slow the time to cancer progression, reports a study in The Journal of Urology, an Official Journal of the American Urological Association

10 Nov 2022

Monkeypox virus infection and its persistence in the testes of infected crab-eating macaques

Researchers performed retrospective detection of the monkeypox virus in the testes of nonhuman primates.

22 Oct 2022

More frequent chest imaging may benefit certain colorectal cancer patients

Colorectal cancer patients with certain clinical characteristics may benefit from more frequent chest imaging to help identify and target cancer that has spread to the lungs, according to new research presented at the Scientific Forum of the American College of Surgeons (ACS) Clinical Congress 2022.

17 Oct 2022

Newly identified process keeps some immune cells on their toes

Cancer cells use an unusual mechanism to migrate into new tissue and form metastases there. The same process probably also keeps some immune cells on their toes.

14 Oct 2022

The association of BNT16B2b2 mRNA COVID-19 vaccine with thrombocytopenia and pneumonitis: A case report

The case report of a patient who developed pneumonitis and thrombocytopenia concurrently after being administered the COVID-19 vaccine.

11 Oct 2022

Virology of the human monkeypox virus

A new review to be posted in the Virus Research journal aims to provide an overview of the recent advances reported concerning hMPXV virology.

21 Sep 2022

Monkeypox infection in a smallpox-vaccinated patient

In a recent study published in the Emerging Infectious Diseases journal, researchers at Madigan Army Medical Center assessed the characteristics of monkeypox infection in a patient vaccinated against smallpox.

20 Sep 2022

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

In a recent study posted to the bioRxiv* preprint server, researchers in the United States assessed the role of two cytokines, interferon-gamma (IFN-γ) and interleukin-10 (IL-10), in regulating immune cell responses and inflammation early during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in rhesus macaques.

18 Sep 2022

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

This study is led by Dr. Ruifu Yang, Dr. Zongmin Du (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology) and Dr. Fan Bai (Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University).

16 Sep 2022

Study shows vaccine-derived poliovirus in infant with severe immunodeficiency

The virology, epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies associated with monkeypox

Scientists have described the epidemiology, transmission, clinical features, diagnosis, treatment, and preventive strategies of monkeypox infection among humans.

6 Sep 2022

Lymph Node News and Research

Further Reading

Cancer immunotherapies can become more potent depending on the time of day

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

New ASTRO guideline provides recommendations on the use of radiation therapy for endometrial cancer

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Air pollution-triggered immune surveillance deficits in the lungs increase the risk of respiratory diseases with aging

The impact of Pfizer‐BioNTech’s BNT162b2 mRNA vaccine booster on the maximum oxygen uptake capacity among recreational endurance athletes

Researchers develop a new method to map the spatial evolution of cancers

Study shows benefits of metastasis-directed therapy without ADT for oligorecurrent prostate cancer

Monkeypox virus infection and its persistence in the testes of infected crab-eating macaques

More frequent chest imaging may benefit certain colorectal cancer patients

Newly identified process keeps some immune cells on their toes

The association of BNT16B2b2 mRNA COVID-19 vaccine with thrombocytopenia and pneumonitis: A case report

Virology of the human monkeypox virus

Monkeypox infection in a smallpox-vaccinated patient

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

Study shows vaccine-derived poliovirus in infant with severe immunodeficiency

Study indicates that HIV-infected and uninfected patients have similar monkeypox illness outcomes

Discovery sheds light on an important aspect of gut health and mucosal immunity

The virology, epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies associated with monkeypox

Immunology eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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