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Why clinical proteomics faces a mass spectrometry vs. high-throughput profiling dilemma

This Clinical Chemistry and Laboratory Medicine review examines a central challenge in precision medicine: whether medical laboratories should prioritize metrologically sound, proteoform-resolving protein quantification by mass spectrometry or adopt scalable, affinity-based proteome profiling platforms built for high-throughput discovery and machine learning. It concludes that while emerging proteomics technologies expand diagnostic possibilities, careful validation, standardization, and quality assurance will be essential, with a hybrid path likely offering the most practical way forward.

19 Apr 2026

Key gene variants tied to developmental dysplasia of the hip and osteoarthritis

Developmental dysplasia of the hip (DDH) is a polygenetic disorder that increases the risk of hip osteoarthritis.

17 Apr 2026

AI-designed peptides break through the outer defenses of MRSA bacteria

A newly-designed AI-powered tool is effective in developing treatments to attack antibiotic-resistant bacteria by breaking down their outer defenses, according to new research from Houston Methodist.

17 Apr 2026

New grant funds AI search for genetic targets to treat Alzheimer's

With a new $6.2 million, five-year grant from the National Institute on Aging, researchers at Case Western Reserve University will use artificial intelligence (AI) and machine learning to identify possible genetic targets to treat Alzheimer's disease.

15 Apr 2026

Registry data and AI can identify high risk populations for skin cancer

Healthcare registry data can show early risk patterns for melanoma skin cancer, according to a study from the University of Gothenburg.

15 Apr 2026

Study finds long COVID leaves a distinct immune signature in the blood

Researchers identified a small panel of inflammatory and neurology-related blood proteins that may help distinguish long COVID from recovery or no prior infection, while also showing that booster vaccination did not appear to worsen these protein responses in this cohort. The study also found that immune responses after reinfection differed from those seen after the first SARS-CoV-2 infection, suggesting altered long-term immune behavior in some previously infected individuals.

14 Apr 2026

Microplastics lab studies may fail to reflect real-world exposure

Microplastics pose health risks, but lab studies often fail to reflect real-world exposure, highlighting critical gaps in toxicological research methodologies.

14 Apr 2026

New method boosts AI-driven protein engineering with massive data

Protein engineering is a field primed for artificial intelligence research. Each protein is made up of amino acids; to optimize a protein function, researchers modify proteins by switching out one of 20 different amino acids for another.

13 Apr 2026

Study identifies intersectional biases affecting care for sickle cell patients

In season 1, episode 2 of the popular show The Pitt, a Black woman with sickle cell disease arrives at the emergency department in acute pain, only to be initially dismissed as drug-seeking.

13 Apr 2026

Novel antibiotic compound shows promise against MRSA skin infections

The development of new antibiotics to treat superbugs and other bacterial infections is a global priority, with the rate of infections that cannot be treated with current antibiotics rising and presenting one of the biggest threats to human health.

11 Apr 2026

Revvity unveils its Signals BioDesign offering to advance biologic research workflows

Revvity, Inc. announced that its Revvity Signals Software business is launching Signals BioDesign™, a cloud-native molecular cloning solution that streamlines biologics research workflows.

From Revvity Signals Software Inc. 10 Apr 2026

AI models may amplify bias in psychiatric aggression predictions

A first-of-its-kind study led by researchers at the Centre for Addiction and Mental Health (CAMH) has found that artificial intelligence (AI) models used to predict aggressive incidents in acute psychiatric care can reinforce and amplify existing social and structural inequities by overestimating the likelihood of aggression among already marginalized groups.

7 Apr 2026

New blood test spots four cancers and other diseases by stripping away healthy DNA noise

MethylScan is a new low-cost cell-free DNA methylome test that removes much of the healthy blood DNA background, helping rare disease signals stand out more clearly. In more than 1,000 people, it showed strong performance for detecting four cancers, classifying liver diseases, and identifying organ-specific damage.

7 Apr 2026

Interpretable machine learning model advances analysis of complex genetic traits

A new study published in Genome Research presents an interpretable artificial intelligence framework that improves both the accuracy and transparency of genomic prediction, a key challenge in fields such as precision medicine, crop science, and animal breeding.

7 Apr 2026

AI helps researchers find antimicrobial peptides in Earth’s harshest habitats

Researchers built the Extreme Environment Microbiome Catalog from 78,213 genomes across global extreme habitats, revealing major taxonomic and biosynthetic novelty, including 32,715 representative species, nearly 4 billion non-redundant genes, and 163,693 biosynthetic gene clusters. They then used protein language models to identify 3,032 candidate non-toxic antimicrobial peptides, with 84 of 100 synthesized peptides showing antibacterial activity and low cytotoxicity in the 50 tested in mammalian cells.

6 Apr 2026

Biological neural networks may serve as viable alternatives to machine learning models

A research team at Tohoku University and Future University Hakodate has demonstrated that living biological neurons can be trained to perform a supervised temporal pattern learning task previously carried out by artificial systems.

3 Apr 2026

Machine learning uncovers thousands of unknown bacterial immune defense systems

Bacterial immune systems protect against viral invaders called phages by precisely targeting specific phage genetic sequences.

2 Apr 2026

Moderate wine intake tied to slower biological aging in men

Researchers studying 22,495 adults in Southern Italy found that men with moderate wine intake in the traditional Mediterranean diet range showed slightly slower biomarker-based biological aging, with the lowest estimated aging signal at about 170 mL per day. The study also found that overall ethanol intake did not show the same moderate-level pattern, and higher total alcohol intake was linked to faster biological aging in dose-response analyses.

2 Apr 2026

New method improves reliability of protein language model predictions

AI language models, used to generate human-like text to power chatbots and create content, are also revolutionizing biology by treating complex biological data like a language.

1 Apr 2026