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Breakthrough study sheds light on Pol-theta’s role in DNA repair and cancer

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these proteins-called polymerase theta (Pol-theta)-for their own survival.

4 Mar 2025

Targeting mitochondrial DNA integrity for cardiac protection after injury

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant role in ischemia/reperfusion (I/R) injury.

4 Mar 2025

New tool could revolutionize brain tumor surgery with rapid cancer cell detection

A novel tool for rapidly identifying the genetic "fingerprints" of cancer cells may enable future surgeons to more accurately remove brain tumors while a patient is in the operating room, new research reveals.

25 Feb 2025

Study challenges role of BRCA1 mutation in prostate cancer initiation

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its kind, published online in the open access journal BMJ Oncology.

24 Feb 2025

Rare enterovirus strain in Spain raises alarms over potential outbreaks

Scientists in Spain detected Enterovirus C105 (EV-C105), a rare virus linked to respiratory and possible neurological illness in children, highlighting the emergence of a genetically distinct viral strain.

17 Feb 2025

New biomarker can accurately predict outcomes in meningiomas and breast cancers

Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD Anderson Cancer Center have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers.

13 Feb 2025

Could yogurt help prevent certain colorectal cancers? New study explores the link

Regular yogurt intake may lower the risk of Bifidobacterium-positive colorectal cancer, particularly in the proximal colon, but does not reduce the risk of Bifidobacterium-negative tumors. Further research is needed to confirm these findings and understand yogurt’s role in gut health and cancer prevention.

13 Feb 2025

Tick-borne encephalitis emerges in Britain: Experts urge vigilance

Tick-borne encephalitis virus (TBEV) has now been confirmed in locally acquired human cases in the U.K., with evidence of established transmission in British tick populations. Increased surveillance and clinician awareness are crucial to detecting and managing this emerging threat.

10 Feb 2025

E64FC26 inhibits inflammation and joint destruction in rheumatoid arthritis models

Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the endoplasmic reticulum.

10 Feb 2025

Targeting ELK3 could offer new therapy for rheumatoid arthritis

Rheumatoid arthritis (RA) is an inflammatory arthritis characterized by chronic joint inflammation, cartilage degradation, and bone erosion.

7 Feb 2025

Dysregulation of RNA-binding proteins in rheumatoid arthritis and osteoarthritis

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of RNA-binding proteins (RBPs), which are critical for alternative mRNA splicing and translational control in rheumatoid arthritis (RA).

6 Feb 2025

Natural immunity to SARS-CoV-2 weakened significantly after Omicron’s emergence

Findings indicate a sharp drop in immunity after Omicron infection, stressing the necessity for updated vaccines to enhance protection against reinfection.

6 Feb 2025

Prolonged REM sleep latency linked to Alzheimer’s disease biomarkers

Research indicates longer REM latency is associated with higher Alzheimer's biomarkers, pointing to its potential as an early indicator of neurodegeneration.

29 Jan 2025

Dietary intervention restores gut microbiome and offers protection against chronic diseases

Findings indicate that a microbiome restoration diet improves gut health and reduces chronic disease markers, highlighting its cardiometabolic benefits.

27 Jan 2025

New discovery sheds light on how bacteria use plasmids to build resistance

An international collaboration has achieved an important breakthrough in understanding the genetic mechanisms that allow bacteria to build resistance to drugs.

23 Jan 2025

Real-world effectiveness and safety of olaparib in HRD-positive BRCA wild-type ovarian cancer

Ovarian cancer, a deadly gynecologic malignancy, has seen a significant shift in its treatment paradigm with the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, which are now standard in the maintenance setting following first-line chemotherapy.

23 Jan 2025

U.S. mosquito species show minimal risk of spreading Oropouche virus, study finds

US mosquito species exhibit minimal competence for transmitting Oropouche virus (OROV), with low infection and transmission rates across tested populations, suggesting limited potential for local outbreaks despite rising imported cases.

22 Jan 2025

Antidepressant fluoxetine found ineffective for early COVID-19 treatment

Findings reveal fluoxetine's weak antiviral effects in COVID-19, with no significant benefits in symptom resolution compared to other antiviral treatments.

22 Jan 2025

Azvudine beats paxlovid in reducing COVID-19 deaths

In hospitalized COVID-19 patients, azvudine shows lower all-cause mortality and fewer adverse events than Paxlovid, with added antitumor effects observed.

21 Jan 2025

Breakthrough study maps critical structure of Nipah virus polymerase

Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999.

20 Jan 2025