Pathogen News and Research

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Researchers identify key role of enzyme essential for invasion of the toxoplasmosis parasite

Scientists from the universities of Geneva and Zurich and the PSI have identified the structure and functions of RON13, an enzyme of the toxoplasmosis parasite that is essential for the infectious mechanism in humans.

24 Jun 2021

UCLA scientists discover how immune cells can be trained to fight potential threats

The body's immune cells naturally fight off viral and bacterial microbes and other invaders, but they can also be reprogrammed or "trained" to respond even more aggressively and potently to such threats, report UCLA scientists who have discovered the fundamental rule underlying this process in a particular class of cells.

24 Jun 2021

Pronation maneuvers for critically ill COVID-19 patients - multidisciplinary management reduce complications

A recent study aimed to determine the efficacy of pronation maneuvers by the ICU physiotherapy team when used on critically ill COVID-19 patients.

24 Jun 2021

New study suggests an earlier and faster spread of COVID-19 than initially thought

Researchers from Kent University in the UK have shown that the first coronavirus disease (COVID-19) patient likely dates back to October 2019. They also found that the spread to other continents of its causative pathogen – the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – occurred faster and sooner.

24 Jun 2021

Nanotechnology and artificial intelligence may be valuable components in securing global food production

An international team of researchers led by scientists at the University of Birmingham, UK, developed a series of steps to follow that could harness AI and integrate the power of nanomaterials safely, sustainably and responsibly, into agricultural practices..

24 Jun 2021

New insights can pave the way for targeted therapies to fight blood clots in COVID-19 patients

Driven by the mystery of the blood clots reported in both living and deceased COVID-19 patients, researchers from Shoolini University, India, dig deeper into the pathogenesis of COVID-19 and other similar viral diseases, looking for ways in which these clots could be formed.

24 Jun 2021

Increased severity of COVID-19 in pregnancy

A new preprint on the medRxiv* server provides more evidence that COVID-19 likely causes a more serious phenotype to arise in pregnant women.

23 Jun 2021

SARS-CoV N protein elicits production of IFN-β by provoking ubiquitination of RIG-I, finds study

A recent study published in Frontiers in Immunology focuses on the roles of the SADS-CoV N protein in IFN suppression during infection.

23 Jun 2021

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian A-kinase anchoring protein enzyme, AKAP7, that shares the same function. Together called 2’,5’-PEs, these enzymes all break down 2’,5’-oligoadenylate compounds that activate the antiviral enzyme ribonuclease L (RNase L).

21 Jun 2021

Can a prior rhinovirus infection protect against COVID-19?

Researchers at the Yale School of Medicine found that rhinovirus accelerates interferon-stimulated genes.

21 Jun 2021

Study reveals how immune cells coordinate their swarming behavior to eliminate pathogens

The body is well protected against invading pathogens by barriers such as the skin. But if you injure yourself and break your skin, pathogens can easily enter your body through the wound and cause severe infections.

21 Jun 2021

Combination of doxycycline and TB drug treatment reduces the size of lung cavities

Globally, an estimated 10 million people develop tuberculosis (TB) each year and the disease remains a leading cause of death from a single infectious agent. Standard short-course anti-TB treatment still requires a regimen of at least six months of antimicrobial drugs, and drug-resistant TB is an increasing public health threat.

21 Jun 2021

A new strategy to combat pathogenic bacterium

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium present in many ecological niches, such as plant roots, stagnant water or even the pipes of our homes. Naturally very versatile, it can cause acute and chronic infections that are potentially fatal for people with weakened immune systems.

21 Jun 2021

RIG-1 agonist shows potent antiviral efficacy against SARS-CoV-2 infection

A team of scientists from the United States has recently revealed the antiviral efficacy of stem-loop RNA 14, a RIG-1 agonist, in controlling severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice. The compound reduces the risk of severe coronavirus disease 2019 (COVID-19) by inhibiting viral replication in the lower respiratory tract. The study is currently available on the bioRxiv* preprint server.

18 Jun 2021

Scientists develop low-cost lab-on-paper device for rapid and accurate detection of SARS-CoV-2

A team of scientists from the University of Connecticut, USA, has developed a low-cost lab-on-paper technology to rapidly and easily detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The work has recently been published in a Royal Society of Chemistry’s Lab on a Chip journal.

18 Jun 2021

Pathogen News and Research

Researchers identify key role of enzyme essential for invasion of the toxoplasmosis parasite

UCLA scientists discover how immune cells can be trained to fight potential threats

Pronation maneuvers for critically ill COVID-19 patients - multidisciplinary management reduce complications

New study suggests an earlier and faster spread of COVID-19 than initially thought

Nanotechnology and artificial intelligence may be valuable components in securing global food production

New insights can pave the way for targeted therapies to fight blood clots in COVID-19 patients

Increased severity of COVID-19 in pregnancy

SARS-CoV N protein elicits production of IFN-β by provoking ubiquitination of RIG-I, finds study

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

Can a prior rhinovirus infection protect against COVID-19?

Study reveals how immune cells coordinate their swarming behavior to eliminate pathogens

Combination of doxycycline and TB drug treatment reduces the size of lung cavities

A new strategy to combat pathogenic bacterium

RIG-1 agonist shows potent antiviral efficacy against SARS-CoV-2 infection

Scientists develop low-cost lab-on-paper device for rapid and accurate detection of SARS-CoV-2

COVID-19 outbreak in Mauritius dominated by new SARS-CoV-2 variant B.1.1.318

Texas Biomed scientists receive $1 million NIH funding for Ebola research

Medieval plague victims were buried with considerable care and attention, shows study

Research may lead to rapid, accurate, point-of-care testing for COVID

Study reveals potentially druggable process of SARS-Cov-2 assembly and replication

Best practices - optimize qPCR processes for pathogen detection eBook

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