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Study reveals variability in polygenic risk scores for predicting heart disease

Polygenic risk scores (PRSs) are a cutting-edge tool in genetics, combining information from genetic markers across the genome to estimate a person's risk of developing certain diseases, such as coronary artery disease (CAD).

19 Nov 2024

Anti-obesity drugs show promise in improving cardiovascular health beyond weight loss

Popular anti-obesity drugs continue to show cardiovascular benefits beyond weight loss, according to several new papers published in JACC, the flagship journal of the American College of Cardiology, that are being simultaneously presented at the American Heart Association's 2024 Scientific Sessions.

19 Nov 2024

Adding high-dose IV vitamin C to chemotherapy can boost survival for pancreatic cancer patients

Results from a randomized phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months.

19 Nov 2024

Memories of obesity can linger in fat cells long after weight loss

Epigenetic changes from obesity persist after weight loss, altering fat cell function and increasing the risk of weight regain, impacting metabolic health.

19 Nov 2024

Study defines three subtypes of Chiari type-1 malformation to guide treatment

Roughly 4% of the population is affected by a congenital brain malformation that has eluded researchers' efforts to find causes and treatments.

19 Nov 2024

Reconditioned pacemakers prove safe and effective in global trial

A randomized trial that compared previously used and new pacemakers in patients found the reconditioned devices were as safe and effective as new pacemakers, potentially offering affordable options for patients in low-and middle-income countries.

18 Nov 2024

New risk score identifies heart disease risk in kidney transplant patients

Using an innovative risk score assessment score, heart researchers at Intermountain Health in Salt Lake City say they can accurately predict whether patients being assessed for kidney transplant will likely have a future major cardiac event, like a heart attack or stroke, according to a new study.

18 Nov 2024

Edoxaban proves effective in preventing blood clots, stroke after heart valve surgery

Edoxaban, an oral anticoagulant, was equally or more effective than warfarin in reducing the risk of stroke and blood clots for patients after heart valve replacement surgery, according to preliminary late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

18 Nov 2024

Intravenous infusion of exenatide fails to reduce risks of complications in heart surgery patients

A large-scale clinical trial found that intravenous infusion of exenatide, a glucagon-like peptide-1 (GLP-1) analog medication, during heart surgeries involving bypass did not significantly reduce the risk of death, stroke or organ failure.

18 Nov 2024

New clinical trial offers hope for patients with rare immune disease IgG4-RD

A team led by Mass General Brigham researchers demonstrated that inebilizumab reduced the risk of symptoms by 87% in patients with the rare affliction known as immunoglobulin G4–related disease (IgG4-RD)

18 Nov 2024

Growth hormone-releasing hormone transforms therapeutic potential in health and chronic disease

Researchers review the biological activities of growth hormone-releasing hormone and its analogs.

17 Nov 2024

Pulses of light show promise in controlling seizures

In what could one day become a new treatment for epilepsy, researchers at UC San Francisco, UC Santa Cruz and UC Berkeley have used pulses of light to prevent seizure-like activity in neurons.

15 Nov 2024

Gut microbiome found to play key role in chronic disease progression

The gut microbiome, an ecosystem of trillions of microorganisms in the human digestive tract, has been increasingly linked to chronic diseases.

15 Nov 2024

Breakthrough in protein engineering may lead to more effective cancer therapies

Researchers from Auburn University, partnering with the University of Basel in Switzerland, have discovered a new way to make a cancer-targeting protein complex more stable, opening doors to better cancer treatments.

15 Nov 2024

UT Health San Antonio achieves top global ranking for research and clinical medicine

The race to draw the best and brightest students has become an international one, with candidates weighing options not only in their state or country, but also across the globe.

15 Nov 2024

Tirzepatide significantly reduces weight and diabetes risk in patients with obesity and prediabetes

Tirzepatide shows promise in reducing weight and preventing diabetes progression in people with obesity and prediabetes, with lasting benefits and manageable side effects.

14 Nov 2024

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

An international, phase 3 clinical trial led by investigators at Mass General Brigham could improve the treatment of a rare disease that can cause debilitating symptoms.

14 Nov 2024

Advances in bladder cancer treatments offer hope for curative care

Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to an editorial published in the New England Journal of Medicine.

14 Nov 2024

New vaccine shows potential in preventing recurrence of triple-negative breast cancer

A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors.

14 Nov 2024

Primary care clinicians key to achieving optimal cardiovascular health

Primary care clinicians and practices are uniquely positioned to help people achieve optimal cardiovascular health through screening, diagnosing and treating the health behaviors and factors outlined in the American Heart Association's Life's Essential 8 health metrics to reduce the risk for heart disease and stroke, according to a new scientific statement published today in the Association's peer-reviewed journal Circulation: Cardiovascular Quality and Outcomes.

13 Nov 2024

Surgery News and Research

Study reveals variability in polygenic risk scores for predicting heart disease

Anti-obesity drugs show promise in improving cardiovascular health beyond weight loss

Adding high-dose IV vitamin C to chemotherapy can boost survival for pancreatic cancer patients

Memories of obesity can linger in fat cells long after weight loss

Study defines three subtypes of Chiari type-1 malformation to guide treatment

Reconditioned pacemakers prove safe and effective in global trial

New risk score identifies heart disease risk in kidney transplant patients

Edoxaban proves effective in preventing blood clots, stroke after heart valve surgery

Intravenous infusion of exenatide fails to reduce risks of complications in heart surgery patients

New clinical trial offers hope for patients with rare immune disease IgG4-RD

Growth hormone-releasing hormone transforms therapeutic potential in health and chronic disease

Pulses of light show promise in controlling seizures

Gut microbiome found to play key role in chronic disease progression

Breakthrough in protein engineering may lead to more effective cancer therapies

UT Health San Antonio achieves top global ranking for research and clinical medicine

Tirzepatide significantly reduces weight and diabetes risk in patients with obesity and prediabetes

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

Advances in bladder cancer treatments offer hope for curative care

New vaccine shows potential in preventing recurrence of triple-negative breast cancer

Primary care clinicians key to achieving optimal cardiovascular health

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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