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Brain folds formed during fetal development could affect age at onset in frontotemporal dementia

Frontotemporal dementia begins relatively early compared to other forms of dementia. We still know relatively little about what causes the disease, however, new research from Lund University in Sweden shows that the folds in the brain that are formed in the latter stages of pregnancy could have an impact on the age at which the disease takes hold.

3 May 2022

Features of SARS-CoV-2 Omicron BA.2 sublineage spike protein

Researchers assessed the traits of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sublineage spike (S) protein.

3 May 2022

Research shows how Alzheimer's disease affects the functional architecture of the brain

A new study led by investigators at Massachusetts General Hospital (MGH) shows the impact of early amyloid-β and tau protein accumulation on disrupting connections between brain structures that are important for memory.

3 May 2022

Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

In a study published May 02, 2022 in Nature Communications, scientists at University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development.

2 May 2022

Tracking BA.2.12.1 🦠 by partial ORF1ab gene 🧬 target failure (pOGTF)

Scientists from the United States have recently identified a novel approach to rapidly and accurately detect the omicron BA.2.12.1 sub-lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples.

2 May 2022

Combining two cancer drugs can be effective in treating specific type of colorectal cancer, study shows

Researchers at the Case Western Reserve University School Medicine have found that combining two cancer drugs can be effective in treating a specific type of colorectal cancer, according to a new study published in Nature Communications.

2 May 2022

P681 mutations in SARS-CoV-2 spike protein determine fusogenicity

Researchers evaluated the importance of the P681 residue within the furin cleavage site of SARS-CoV-2 spike protein in determining the fusogenicity and syncytia formation ability of SARS-CoV-2 strains.

2 May 2022

SARS-CoV-2-specific T cells are broader after vaccination than after infection

In a recent study published in the Nature Microbiology journal, researchers investigated the characteristics of coronavirus disease 2019 (COVID-19) infection in convalescent and vaccinated individuals.

1 May 2022

Antibody cocktail shows synergetic effects against SARS-CoV-2 Omicron in vitro and in vivo

A recent research paper posted to the bioRxiv* preprint server demonstrated that a cocktail of two synergetic antibodies extensively neutralized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including Omicron BA.1 and BA.2.

1 May 2022

Scientists gain important insights into novel mutation behind synucleinopathies

Parkinson's disease and Lewy body dementia belong to a family of neurodegenerative disorders called synucleinopathies because they are caused by the pathological accumulation of protein alpha-synuclein into structures called Lewy bodies and Lewy neurites in the brain.

29 Apr 2022

Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

In a new study, researchers described their self-designed chimeric receptor-binding domain-dimer vaccine approach to adapt SARS-CoV-2 variants of concern and variants of interest.

29 Apr 2022

Tufts scientists discover a previously unknown function performed by astrocytes

Researchers at Tufts University School of Medicine have discovered a previously unknown function performed by a type of cell that comprises nearly half of all cells in the brain.

28 Apr 2022

Study shows how DNA changes in Barrett's esophagus cells may predict esophageal cancer

More and more mutations clutter up our DNA as we age. Mostly, these don't cause problems. But sometimes, a switch will flip, and a mutated cell turns cancerous. Can we see this shift in time to prevent or treat cancer before it starts?

28 Apr 2022

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

Researchers identified a human monoclonal antibody (mAb), 87G7, with in vitro neutralizing activity against several SARS-CoV-2 VOCs, including Alpha, Beta, Gamma, Delta, and Omicron.

28 Apr 2022

Mutation News and Research

Brain folds formed during fetal development could affect age at onset in frontotemporal dementia

Features of SARS-CoV-2 Omicron BA.2 sublineage spike protein

Research shows how Alzheimer's disease affects the functional architecture of the brain

Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

Tracking BA.2.12.1 🦠 by partial ORF1ab gene 🧬 target failure (pOGTF)

Combining two cancer drugs can be effective in treating specific type of colorectal cancer, study shows

P681 mutations in SARS-CoV-2 spike protein determine fusogenicity

SARS-CoV-2-specific T cells are broader after vaccination than after infection

Antibody cocktail shows synergetic effects against SARS-CoV-2 Omicron in vitro and in vivo

Scientists gain important insights into novel mutation behind synucleinopathies

Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

Tufts scientists discover a previously unknown function performed by astrocytes

Study shows how DNA changes in Barrett's esophagus cells may predict esophageal cancer

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

MAPK pathway mutations can provide “precision” treatment targets for head and neck cancer

Discovery of novel antibody that targets shared epitope on SARS-CoV-2 variants

Misexpression of non-cardiac genes may lead to congenital heart disease

Genetic cause of lupus identified

Gene discovery could pave the way for new and more effective treatments for lupus

Bebtelovimab potently neutralizes all SARS-CoV-2 variants of concern

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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