in vivo News and Research

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NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

NeoCura and PhoreMost today announced an oncology drug discovery research collaboration.

From PhoreMost 11 Jan 2022

SARS-CoV-2 activates microglia in the brain

Researchers demonstrate that SARS-CoV-2 can infect the human microglia.

10 Jan 2022

Neurologist receives ERC grant to study novel light-activated drugs with antiepileptic effects

Dr. Michael Wenzel from the Department of Epileptology at the University Hospital Bonn has received a coveted Starting Grant from the European Research Council.

10 Jan 2022

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

Researchers screened BNT162b2 COVID-19 vaccine recipients and cloned broadly neutralizing antibodies from an elite vaccinee.

10 Jan 2022

Therapeutic in vivo synthetic chemistry used to make anticancer drugs

An international research group at the RIKEN Cluster for Pioneering Research (CPR) has successfully treated cancer in mice using metal catalysts that assemble anticancer drugs together inside the body.

10 Jan 2022

SARS-CoV-2 shown to spread through cell-to-cell transmission

A new study investigated SARS-CoV-2 cell-to-cell transmission in the context of cell-free infection and compared it to SARS-CoV.

10 Jan 2022

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

In a new study, researchers used a cell-cell fusion assay to extract potentially cleaved spike protein products from syncytia in order to explore the functional and biochemical characteristics of spike (S) protein when it engages its receptor ACE2 in living cells.

10 Jan 2022

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Characterizing these engineered sEVs, the researchers demonstrated that the soluble angiotensin-converting enzyme 2 (sACE-2) loaded sEV successfully binds and thus inhibits the entry of wild-type SARS-CoV-2 as well as its variants, protecting against SARS-CoV-2 infection. They also demonstrated the therapeutic efficacy of these engineered sEVs in vivo.

9 Jan 2022

Study finds novel pathway for understanding why debilitating conditions happen for cancer patients

Severe and persistent disability often undermines the life-saving benefits of cancer treatment. Pain and fatigue - together with sensory, motor, and cognitive disorders - are chief among the constellation of side effects that occur with the platinum-based agents used widely in chemotherapy treatments worldwide.

9 Jan 2022

Dual-receptors help widespread dissemination of SARS-CoV-2

Researchers demonstrate the role of integrins in the establishment of the SARS-CoV-2 infection.

9 Jan 2022

Study shows probiotics can reduce symptoms of COVID-19 when taken post-exposure

A new study shows how a daily use of Lactobacillus rhamnosus GG (LGG) probiotic may protect against symptom development in instances when it is used as post-exposure prophylaxis within seven days after exposure to severe acute respiratory syndrome coronavirus 2.

7 Jan 2022

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

Researchers from India have now successfully grown and isolated the Omicron variant from hamsters in vivo with further culturing in the Vero CCL-81 cells in vitro, in a step forward towards testing the effectiveness of existing SARS-CoV-2 vaccines and generation of new Omicron appropriate vaccines.

7 Jan 2022

In vivo generation of engineered CAR T cells can reduce fibrosis and restore cardiac function after heart injury

A novel immunotherapy strategy using in vivo generation of transient engineered chimeric antigen receptor (CAR) T cells, through the delivery of modified mRNA, can reduce fibrosis and restore cardiac function in a mouse model of heart failure, researchers report.

6 Jan 2022

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

An experimental immunotherapy can temporarily reprogram patients' immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2022

in vivo News and Research

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

SARS-CoV-2 activates microglia in the brain

Neurologist receives ERC grant to study novel light-activated drugs with antiepileptic effects

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

Therapeutic in vivo synthetic chemistry used to make anticancer drugs

SARS-CoV-2 shown to spread through cell-to-cell transmission

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Study finds novel pathway for understanding why debilitating conditions happen for cancer patients

Dual-receptors help widespread dissemination of SARS-CoV-2

Study shows probiotics can reduce symptoms of COVID-19 when taken post-exposure

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

In vivo generation of engineered CAR T cells can reduce fibrosis and restore cardiac function after heart injury

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

Researchers study immune cell invasion process in living fruit fly embryos

Scientists unravel how LPS prevents or promotes development of allergic disease

Anti-fogging sprays and cloths may contain high levels of PFAS, finds study

Exploring SARS-CoV-2-like viruses to mitigate the risk of zoonotic transmission to humans

Oral bacteria-based SARS-CoV-2 vaccine platform

Transplant recipients benefit from a COVID-19 vaccine booster

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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