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QTQTN motif upstream of furin-cleavage site in SARS-CoV-2 infection and pathogenesis

A new study posted to the bioRxiv* preprint server aimed to demonstrate whether the loss of the QTQTN motif attenuates SARS-CoV-2 replication in respiratory cells in vitro and pathogenesis in hamsters.

20 Dec 2021

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Researchers conduct a comprehensive in vitro analysis of relatively unexplored host immune responses during SARS-CoV-2 infection.

20 Dec 2021

Traditional medicinal plant alleviates malaria symptoms in mice

The active plant ingredient anemonin could provide a new approach in the treatment of malaria. It was identified by researchers from Ethiopia and Germany in a buttercup that is traditionally used in some African countries as a medicinal plant to treat malaria.

20 Dec 2021

Study: Common gene mutation for Parkinson's disease drives mislocalization of iron in the brain

A common gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia, according to a new study publishing December 16th in the open-access journal PLOS Biology, by Mark Cookson of the National Institute on Aging and colleagues

17 Dec 2021

Experimental and computational synergy considered a promising approach in COVID-19 patients

Thanks to the large amount of -omics data becoming increasingly available, sophisticated computational models are developed for new fields such as immunology and the predictions they generate will help identify key molecules in inflammatory processes.

16 Dec 2021

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Scientists identified a human monoclonal antibody (mAb), which successfully neutralized or bound all sarbecoviruses tested in vitro.

16 Dec 2021

BrainGlobe; An Open-Source Platform for Neuroscientists

An interview with Professor Troy Margrie, Associate Director of the Sainsbury Wellcome Centre, and Dr. Adam Tyson, Scientific Software Lead at the Institute of Cancer Research.

15 Dec 2021

CellPort Software joins the Tetra Partner Network to help customers accelerate cell development and manufacturing

TetraScience, the R&D Data Cloud company, announced today that CellPort Software, a SaaS company that digitizes workflows for cell development and manufacturing, has joined the Tetra Partner Network to accelerate delivery of cell-based therapeutics.

From TetraScience, Inc. 15 Dec 2021

Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia. Despite advances in treatments, patients have an extremely poor prognosis, highlighting the need to explore the genetic components that lead to the formation of T-ALL, as well as the need to discover new targeted therapeutic approaches and treatment resistance.

14 Dec 2021

Evaluating the virucidal activity of blue LED light against SARS-CoV-2 infection

A new study provides some possible explanations to the mechanisms by which antiviral activity is exerted by blue LED light and indicated that the alteration of the SARS-CoV-2 spike protein requires the presence of photosensitizers.

13 Dec 2021

Genetic-code expansion technique to potentially create next-generation vaccine candidate

A new experiment devised a novel method to manipulate virulent viruses in conventional laboratories and validated the prophylactic effect of this method in two mouse models.

13 Dec 2021

A method to eliminate mutants in the furin cleavage site of SARS-CoV-2 in Calu-3 cells

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12 Dec 2021

Nasal infection drives lethal lung injury due to SARS-CoV-2 in mice

A new study demonstrates lethal infection of the olfactory epithelium in a mouse model that could help understand the mechanisms of COVID-19.

12 Dec 2021

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of "intruding" viruses like human immunodeficiency virus (HIV).

9 Dec 2021

in vivo News and Research

QTQTN motif upstream of furin-cleavage site in SARS-CoV-2 infection and pathogenesis

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Traditional medicinal plant alleviates malaria symptoms in mice

Study: Common gene mutation for Parkinson's disease drives mislocalization of iron in the brain

Experimental and computational synergy considered a promising approach in COVID-19 patients

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

BrainGlobe; An Open-Source Platform for Neuroscientists

CellPort Software joins the Tetra Partner Network to help customers accelerate cell development and manufacturing

Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

Evaluating the virucidal activity of blue LED light against SARS-CoV-2 infection

Genetic-code expansion technique to potentially create next-generation vaccine candidate

A method to eliminate mutants in the furin cleavage site of SARS-CoV-2 in Calu-3 cells

Nasal infection drives lethal lung injury due to SARS-CoV-2 in mice

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

High quality products for cultured meat research

Breastmilk T cell repertoire is enriched for SARS-CoV-2 Spike-specificity after maternal mRNA vaccination

The antiviral potential of 4′-fluorouridine as an oral treatment against RSV and SARS-CoV-2

An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

Cochlear implant recipients develop new bone formation that leads to long-term residual hearing loss

SARS-CoV-2 S2 immunization as a pan-coronavirus vaccine approach

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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