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Immune system derails during severe course of COVID-19

Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction - rather, the immune response is caught in a continuous loop of activation and inhibition.

6 Aug 2020

Study uncovers sex-specific differences in neural mechanisms for glucose regulation

Researchers at Tufts University School of Medicine and Tufts Graduate School of Biomedical Sciences have discovered neural mechanisms in mice specific to females that can shift estrogen from playing a protective role in glucose metabolism to one that is disruptive.

6 Aug 2020

Researchers develop a deep learning-based algorithm for predicting sites of DNA methylation

A team of researchers from New Jersey Institute of Technology and Children's Hospital of Philadelphia have developed an algorithm through machine learning that helps predict sites of DNA methylation - a process that can change the activity of DNA without changing its overall structure - and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.

6 Aug 2020

An 'intelligent' strategy for real-time evaluation of photothermal therapy efficiency on tumors

Photothermal therapy (PTT) is a promising alternative method for cancer treatment due to advantages of non-invasiveness, precise temporal and spatial control, strong specificity and high tumor destruction efficiency.

6 Aug 2020

New insight into the molecular underpinnings of muscle development

In the world of weightlifting, some people gain more muscle faster than others, no matter what they do. Now, a novel human study may explain why this happens.

6 Aug 2020

Research unlocks key mechanism in the communication between brain cells during stroke

Research led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, and Ludmila Belayev, MD, LSU Health New Orleans Professor of Neuroscience, Neurology and Neurosurgery, has unlocked a key fundamental mechanism in the communication between brain cells when confronted with stroke.

6 Aug 2020

Powerful treatment for IPF stops dangerous scar formation in mouse lungs

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

6 Aug 2020

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

6 Aug 2020

Chemists discover a way to create synthetic version of natural anti-cancer compound

Scripps Research chemists Hans Renata, PhD, and Alexander Adibekian, PhD, have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as an anti-cancer agent.

6 Aug 2020

ASH publishes new guidelines to help tailor treatment for older adults with acute myeloid leukemia

Today, ASH published new guidelines to help older adults with acute myeloid leukemia (AML) and their health care providers make critical care decisions, including if and how to proceed with cancer treatment and the need for blood transfusions for those in hospice care.

6 Aug 2020

Tasmanian devil research provides new insights for treating human cancers in future

A rare, transmissible tumor has brought the iconic Tasmanian devil to the brink of extinction, but new research by scientists at Washington State University and the Fred Hutchinson Cancer Research Center in Seattle indicates hope for the animals' survival and possibly new treatment for human cancers.

6 Aug 2020

A new device for modeling the human gut’s complex microbiome environment

Several thousand strains of bacteria live in the human gut. Some of these are associated with disease, while others have beneficial effects on human health.

6 Aug 2020

COVID-19: BCG vaccine is safe and possibly has a positive effect

The BCG vaccine, a vaccine originally made against tuberculosis, has a general stimulating effect on the immune system and is therefore effective against multiple infectious diseases - possibly also against COVID-19.

6 Aug 2020

Specific gene impairment may also protect people with Down syndrome

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that a set of genes with decreased expression in individuals with Down syndrome may lead to clinical abnormalities in this population, such as poor muscle development and heart valve problems.

6 Aug 2020

Synthetic peptide can make multidrug-resistant bacteria sensitive to antibiotics

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a synthetic peptide that can make multidrug-resistant bacteria sensitive to antibiotics again when used together with traditional antibiotics, offering hope for the prospect of a combination treatment strategy to tackle certain antibiotic-tolerant infections.

6 Aug 2020

Cytiva licenses advanced machine learning technology from Allen Institute

Cytiva and the Allen Institute have entered into a license agreement to integrate the Allen Institute's machine learning technology with Cytiva's microscopy and image analysis systems to advance the development of cell imaging innovations.

From Cytiva Life Sciences 6 Aug 2020

UCI researchers develop novel molecule for COVID-19 treatment

When the coronavirus pandemic hit, almost everyone at the University of California, Irvine – and colleges across the nation – had to abandon campus.

6 Aug 2020

Scientists explore mechanisms involved in the development of liver disease

Metabolic fatty liver disease, known as non-alcoholic fatty liver disease, is one of the most common causes of liver disease in Western countries and covers a spectrum of disorders.

6 Aug 2020

Scientists create new mouse model of permanent neonatal diabetes

Diabetes seldom occurs in newborns--a condition known as neonatal diabetes. But when it does, it's mostly due to a mutation in a single gene such as the KCNJ11 or insulin (INS).

6 Aug 2020

Carefully engineered spike protein can help develop COVID-19 vaccine

The experimental vaccine against SARS-CoV-2 that was the first to enter human trials in the United States has been shown to elicit neutralizing antibodies and a helpful T-cell response with the aid of a carefully engineered spike protein that mimics the infection-spreading part of the virus.

6 Aug 2020

B Cell News and Research

Immune system derails during severe course of COVID-19

Study uncovers sex-specific differences in neural mechanisms for glucose regulation

Researchers develop a deep learning-based algorithm for predicting sites of DNA methylation

An 'intelligent' strategy for real-time evaluation of photothermal therapy efficiency on tumors

New insight into the molecular underpinnings of muscle development

Research unlocks key mechanism in the communication between brain cells during stroke

Powerful treatment for IPF stops dangerous scar formation in mouse lungs

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

Chemists discover a way to create synthetic version of natural anti-cancer compound

ASH publishes new guidelines to help tailor treatment for older adults with acute myeloid leukemia

Tasmanian devil research provides new insights for treating human cancers in future

A new device for modeling the human gut’s complex microbiome environment

COVID-19: BCG vaccine is safe and possibly has a positive effect

Specific gene impairment may also protect people with Down syndrome

Synthetic peptide can make multidrug-resistant bacteria sensitive to antibiotics

Cytiva licenses advanced machine learning technology from Allen Institute

UCI researchers develop novel molecule for COVID-19 treatment

Scientists explore mechanisms involved in the development of liver disease

Scientists create new mouse model of permanent neonatal diabetes

Carefully engineered spike protein can help develop COVID-19 vaccine

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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