Polymerase Chain Reaction News and Research

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Polymerase chain reaction (PCR) is a revolutionary laboratory technique that enables the replication of a specific DNA sequence. Using PCR, millions of copies of a target DNA can be easily synthesized within a short period of time.

Anti-N-protein IgG may predict severity of COVID-19

A recent study by researchers at the University of Miami, Miami VA Healthcare System and Express Gene and published on the preprint server medRxiv in September 2020 reports on the prognostic significance of the anti-N Immunoglobulin G (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

28 Sep 2020

Young adults now driving force behind the ongoing COVID-19 pandemic says CDC

The Centers for Disease Control and Prevention (CDC) has released a report stating that the ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is on the rise among young adults and this rise is preventing the pandemic from abating.

27 Sep 2020

Bacteria-free method for making SARS-CoV-2 infectious clones

Using a circular polymerase chain reaction, researchers have developed a method for making severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant virus, with the ability to introduce mutations. The research by Japanese scientists is published on the preprint server bioRxiv* in September 2020.

27 Sep 2020

SARS-CoV-2 emergence linked with decrease in circulation of common respiratory viruses

Analysis of samples taken to test for respiratory viruses over the past five years suggests that the emergence of SARS-CoV-2 was associated with a large drop in circulation of other common respiratory viruses during the first wave.

26 Sep 2020

3D-printed alternative performs as well as the standard nasal swabs for COVID-19 testing

As COVID-19 quickly spread worldwide this spring, shortages of supplies, including the nasopharyngeal (nasal) swabs used to collect viral samples, limited diagnostic testing.

25 Sep 2020

Inflammation in the eye after COVID-19

A new study published on the preprint server medRxiv shows the occurrence of ocular pathology in the period of recovery following COVID-19. This throws more light on the occurrence of inflammation in people recovering from COVID-19.

25 Sep 2020

Challenges in High Complexity Flow Cytometry

In this interview, Dra. Mª José Marco from the Department of Hematology at Hopsital Dr. Peset talks to News-Medical Life Sciences about high complexity flow cytometry and the challenges they often face.

From Beckman Coulter Life Sciences - Flow Cytometry 24 Sep 2020

No discernable difference in SARS-CoV-2 viral loads of young children versus older children and adults

Sharline Madera et al. , in a recent medRxiv* preprint paper, show a detailed investigation of viral nucleic acid among young children and adults, involving over 5,000 cases confirmed by RT-PCR (Reverse Transcriptase – Polymerase Chain Reaction) assay.

23 Sep 2020

Confirmed early re-infection with SARS-CoV-2

As scientists strive to develop commercially viable and effective antivirals and vaccines to counter the growing COVID-19 pandemic, there is considerable uncertainty about how long and how durable the immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is. A new paper recently published in the journal Clinical Infectious Disease in September 2020 reports a confirmed case of re-infection with this virus following recovery.

22 Sep 2020

How COVID-19 flew to Greece

A recent study published in the journal Travel Medicine and Infectious Disease in September 2020 reports a series of cases following travel on a commercial airliner that heralded the earliest imported COVID-19 infections in Greece.

22 Sep 2020

Wastewater analysis predicts COVID-19 spread

The researchers from Yale University provided an outline of the spread of the infection in the community. Their study titled, “Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics,” is published in the latest issue of the journal Nature Biotechnology.

22 Sep 2020

Expanded screening of asymptomatic people could reduce COVID-19 infections and deaths

New research suggests when the COVID-19 pandemic is slowing, low-cost, recurring screening of asymptomatic people - at an expense of approximately $3 or less per test every two weeks - could decrease COVID-19 infections and deaths and be cost-effective.

22 Sep 2020

Oncology nurses should be routinely tested for SARS-CoV-2, warn researchers

Researchers from the NHS Foundation Trust, University of Cambridge and Cambridge Clinical Laboratories have warned that until a vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) becomes available, antigen and antibody testing should be carried out among oncology nurses as part of routine patient care.

21 Sep 2020

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

A recent study published on the preprint server bioRxiv* seeks to establish the pattern of antibody reactivity in COVID-19 convalescent plasma (CCP), which is widely being used as a therapy for seriously ill COVID-19 patients.

21 Sep 2020

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

A team of researchers from Aix-Marseille Univ, IHU-Méditerranée Infection, Institut Paoli Calmettes and Laboratoire d’Immunologie, Marseille, France, conducted experiments to determine if SARS-CoV-2 can affect the myeloid compartment or infect monocytes and macrophages.

20 Sep 2020

Large mother-child paired study promises more answers on COVID-19 in pregnancy

A new paper published in the preprint server medRxiv* in August 2020 reports the design and preliminary findings of an ongoing study on pregnant mothers and their children born during the pandemic.

20 Sep 2020

COVID-19 could be diagnosed using stroke scans

New research from King's College London has found that COVID-19 may be diagnosed on the same emergency scans intended to diagnose stroke.

17 Sep 2020

Testing settled solids in sewage for SARS-CoV-2 more sensitive approach than testing influent

Many studies on the containment of the ongoing COVID-19 pandemic have dealt with the possible role of wastewater in predicting and detecting future outbreaks and understanding the epidemiology of COVID-19 disease. A recent study published on the preprint server medRxiv* in September 2020 shows that solid waste in sewage is a better substrate for testing than influent.

17 Sep 2020

Seropositive partners increase risk of COVID-19 but not obstetric complications in pregnant women

While earlier studies have shown the significance of serological testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant women, their partners have largely been excluded. Now, a new Danish study published on the preprint server medRxiv in September 2020 reports the impact of serologic testing in both pregnant women and their partners, as well as their newborns.

17 Sep 2020

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

In a study published on the bioRxiv preprint server, researchers from the University of Pécs, University of Vienna, and CEBINA GmbH, Vienna, show the ability of the antihistamine azelastine to inhibit SARS-CoV-2 infection in human nasal tissue in vitro.

16 Sep 2020

Polymerase Chain Reaction News and Research

Further Reading

Anti-N-protein IgG may predict severity of COVID-19

Young adults now driving force behind the ongoing COVID-19 pandemic says CDC

Bacteria-free method for making SARS-CoV-2 infectious clones

SARS-CoV-2 emergence linked with decrease in circulation of common respiratory viruses

3D-printed alternative performs as well as the standard nasal swabs for COVID-19 testing

Inflammation in the eye after COVID-19

Challenges in High Complexity Flow Cytometry

No discernable difference in SARS-CoV-2 viral loads of young children versus older children and adults

Confirmed early re-infection with SARS-CoV-2

How COVID-19 flew to Greece

Wastewater analysis predicts COVID-19 spread

Expanded screening of asymptomatic people could reduce COVID-19 infections and deaths

Oncology nurses should be routinely tested for SARS-CoV-2, warn researchers

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

Large mother-child paired study promises more answers on COVID-19 in pregnancy

COVID-19 could be diagnosed using stroke scans

Testing settled solids in sewage for SARS-CoV-2 more sensitive approach than testing influent

Seropositive partners increase risk of COVID-19 but not obstetric complications in pregnant women

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

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