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Antiviral activity of a photoactivable natural product on coronaviruses

A new study showed that pheophorbide a has antiviral activity against many CoVs.

26 Nov 2021

Combination of iota-carrageenan and xylitol as a potential nasal spray for COVID

Researchers determine the inhibition capacity of iota-carrageenan and xylitol in three different candidate preservative-free formulations.

24 Nov 2021

The antimicrobial properties of the lungfish cocoon

Researchers investigate if the immune system of lungfish plays a role in estivation.

24 Nov 2021

Bat coronavirus ecology, evolution, and spillover

In a review published in Nature Reviews Microbiology, the authors collate information about the ecology and evolution of bat coronaviruses.

24 Nov 2021

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

A new study evaluates the efficacy of SNX-5422 as a post-exposure prophylactic treatment.

23 Nov 2021

Semiflexible optoelectrodes for high-resolution neuron readout and stimulation with low damage

The use of electrodes placed inside the brains of laboratory specimens has pushed the field of neuroscience to new findings for decades.

23 Nov 2021

An increase in the half-life of remdesivir for COVID-19 treatment

In this study, researchers analyzed several drug candidates to investigate their efficacy against a broad spectrum of coronaviruses in cell culture studies.

23 Nov 2021

Preexisting rhinovirus infection and IFN induction in epithelium of asthma patients decreases SARS-CoV-2 infection

In a recent study, researchers explored the effects of RV, HDM, and SARS-CoV-2 on differentiated primary human bronchial epithelial cells (HBECs) in vitro and in experimental in vivo RV infection in healthy subjects and asthmatic patients.

22 Nov 2021

Sheep at low-risk for infection with SARS-CoV-2

A team of scientists from the US has recently evaluated the susceptibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in sheep. The findings reveal that sheep are generally less susceptible to SARS-CoV-2 infection. However, the susceptibility is relatively higher for the alpha variant of the virus. The study is currently available on the bioRxiv preprint server.

21 Nov 2021

Predicting the capacity of mammal species to become zoonotic SARS-CoV-2 hosts

Researchers identified a subset of species in which the threat of spillback infection appears the most significant due to location and increased contact with humans in areas with a high prevalence of SARS-CoV-2.

19 Nov 2021

New trial demonstrates stable coagulation factor VIII in hemophilia A patients after gene therapy

A novel gene therapy for hemophilia A led to sustained expression of the clotting factor those patients lack, resulting in a reduction – or in some cases complete elimination – of painful and potentially life-threatening bleeding events, according to a new study led by researchers at Children's Hospital of Philadelphia.

18 Nov 2021

Nanocomputing agent controls the function of protein involved in cell movement, cancer metastasis

The creation of nanoscale computers for use in precision health care has long been a dream of many scientists and health care providers.

16 Nov 2021

ALS also causes retinal alterations, study reveals

Amyotrophic lateral sclerosis (ALS), characterized by harm to brain neurons and to the spinal cord, also affects the tissue of the retina, according to a study headed up by Universidad Complutense de Madrid.

16 Nov 2021

Two genetic risk variants in Black individuals may exacerbate sepsis and COVID-19 severity

Two genetic risk variants that are carried by nearly 40 percent of Black individuals may exacerbate the severity of both sepsis and COVID-19, a team of researchers from the University of Pennsylvania's Perelman School of Medicine have found.

16 Nov 2021

A therapeutic interfering particle for SARS-CoV-2

Researchers report their attempt to engineer TIPs that can conditionally replicate with SARS-CoV-2, inhibit viral replication 10–100 fold, and exhibit R0>1.

16 Nov 2021

NanoTCE technology shows promise for treatment of acute myeloid leukemia

Oncotarget published "Nanoparticle T cell engagers for the treatment of acute myeloid leukemia" which reported that Acute myeloid leukemia (AML) is the most common type of leukemia and has a 5-year survival rate of 25%.

12 Nov 2021

Stem cell enlargement contributes to decline in normal function during aging

MIT biologists have answered an important biological question: Why do cells control their size? Cells of the same type are strikingly uniform in size, while cell size differs between different cell types. This raises the question of whether cell size is important for cellular physiology.

12 Nov 2021

Higher order protein catenation leads to the development of artificial antibodies

Chemical topology is a unique dimension for protein engineering. Over the past few years, the discovery of topological nontrivial proteins in nature has already revealed their many potential functional benefits, such as enhanced thermal/mechanical/chemical stability.

12 Nov 2021

First detection of SARS-CoV-2 remdesivir resistance in an immunocompromised patient

A research group from the US (led by experts from Yale University School of Medicine) recently presented a case of an immunocompromised female patient with acquired deficiency of B lymphocytes who subsequently developed a protracted course of the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

10 Nov 2021

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

A German case study recently published in the journal Nature Communications has characterized a long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics in an immunosuppressed kidney transplant recipient and provided evidence for the evolution of SARS-CoV-2 into potentially harmful immune escape mutants during persistent infections.

10 Nov 2021

in vivo News and Research

Antiviral activity of a photoactivable natural product on coronaviruses

Combination of iota-carrageenan and xylitol as a potential nasal spray for COVID

The antimicrobial properties of the lungfish cocoon

Bat coronavirus ecology, evolution, and spillover

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

Semiflexible optoelectrodes for high-resolution neuron readout and stimulation with low damage

An increase in the half-life of remdesivir for COVID-19 treatment

Preexisting rhinovirus infection and IFN induction in epithelium of asthma patients decreases SARS-CoV-2 infection

Sheep at low-risk for infection with SARS-CoV-2

Predicting the capacity of mammal species to become zoonotic SARS-CoV-2 hosts

New trial demonstrates stable coagulation factor VIII in hemophilia A patients after gene therapy

Nanocomputing agent controls the function of protein involved in cell movement, cancer metastasis

ALS also causes retinal alterations, study reveals

Two genetic risk variants in Black individuals may exacerbate sepsis and COVID-19 severity

A therapeutic interfering particle for SARS-CoV-2

NanoTCE technology shows promise for treatment of acute myeloid leukemia

Stem cell enlargement contributes to decline in normal function during aging

Higher order protein catenation leads to the development of artificial antibodies

First detection of SARS-CoV-2 remdesivir resistance in an immunocompromised patient

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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