Pathogen News and Research

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Researchers identify six “words” used by specific immune cells to call up immune defense genes

UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes -- an important step toward understanding the language the body uses to marshal responses to threats.

13 May 2021

Measuring metabolic 'fluxes' could help scientists advance new tuberculosis drugs

Mycobacterium tuberculosis is incredible in that it can survive for decades within its human host. It does this by varying its diet to successfully steal nutrients from the human host including immune cells; it is known to acquire and absorb multiple carbon sources from the body during infection.

12 May 2021

An Introduction to the Benefits of the Skin Trust Club

In this interview, News-Medical speaks to Dr. David Caballero-Lima, Head of R&D at Labskin, about the applications and benefits of the Skin Trust Club.

11 May 2021

Case study describes consequences of undetected SARS-CoV-2 infection during mRNA vaccination

Now, a new report describes a case of a coincidental mRNA vaccination and SARS-CoV-2 infection in a 31-year-old doctor, addressing the theoretical considerations for potential risks and further required actions in case more cases appear in the future.

11 May 2021

Lab reports 1st instance of SARS-CoV-2 variants affecting antigen test performance

Researchers from the US recently determined the sensitivity of the Quidel Sofia SARS Antigen FIA test (Sofia 2). They found a high viral load specimen that tested negative repeatedly while using this antigen test. The study is published on the preprint server, medRxiv.

10 May 2021

Research suggests Pfizer-BioNTech COVID-19 vaccine reprograms innate immune responses

Researchers in The Netherlands have warned that Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine induces complex reprogramming of innate immune responses that should be considered in the development and use of mRNA-based vaccines.

10 May 2021

Researchers identify first biomarker to predict severity of COVID-19

Severe cases of COVID-19 can now be detected at an early stage. Researchers at the University of Zurich have identified the first biomarker that can reliably predict which patients will develop severe symptoms.

10 May 2021

SARS-CoV-2 main protease conformations are temperature-dependent

New research led by Daniel A Keedy of City University of New York, USA, shows the structure of the main protease (Mpro) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative pathogen of coronavirus disease 2019 (COVID-19) – reacts to being heated and cooled. The temperature-dependent conformations could act as potential therapeutic targets to neutralize the virus.

9 May 2021

New research lays the groundwork for an effective salmonella vaccine

With the COVID-19 vaccines on many people's minds, some may be surprised to learn that we do not yet have vaccines for many common infectious diseases.

7 May 2021

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

An interesting new study describes the emergence of several such variants from a chronically immunosuppressed COVID-19 patient, who remained infected for over 170 days before clearing the virus.

7 May 2021

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

The SARS-CoV-2 was first reported in a case from Wuhan, China, in December 2021, and subsequently became the cause of the COVID-19 pandemic that is ravaging the world today. A new study in the journal Molecular Biology and Evolution tracks its variants all over the world since the onset of the pandemic.

7 May 2021

Bubonic plague had long-term impact on human immune genes, indicates study

Scientists examining the remains of 36 bubonic plague victims from a 16th century mass grave in Germany have found the first evidence that evolutionary adaptive processes, driven by the disease, may have conferred immunity on later generations of people from the region.

7 May 2021

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

In a new study recently published in the journal Science, a team of researchers in the U.S. found that most of the antibodies circulating in the blood target areas of the viral spike protein outside the receptor-binding domain (RBD), the part of the spike that binds directly to human cell receptors.

6 May 2021

Research shows how the world’s population has created an ideal breeding ground for infectious diseases

The way that many of us live has created the “perfect storm” for the evolution and transmission of infectious diseases like Covid-19 according to a researcher at the University of East Anglia.

6 May 2021

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

A team of scientists from the USA and Canada has recently identified and characterized a novel small-molecule compound inhibitor of cellular serine protease TMPRSS2, which shows significant antiviral potency against emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 May 2021

Prior MMR or Tdap vaccination may reduce risk of severe COVID-19

Researchers in the United States have shown that prior Measles-Mumps-Rubella (MMR) or Tetanus-Diphtheria-pertussis (Tdap) vaccination may reduce the risk of severe outcomes in patients with coronavirus disease 2019 (COVID-19).

5 May 2021

Scientists discover fundamental regulation mechanism of proteins

Proteins perform a vast array of functions in the cell of every living organism with critical roles in almost every biological process.

5 May 2021

Mechano-immunological response to SARS-CoV-2

In a recent study, researchers demonstrated a human organ-on-a-chip (Organ Chip) microfluidic model of the lung alveolus (Alveolus Chip) - that recapitulates the human alveolar-capillary interface with an air-liquid interface (ALI) and vascular fluid flow to understand the local triggers in the lung in vitro.

5 May 2021

Study investigates the level of knowledge of young people and adolescents on "zoonotic diseases"

The EU-funded BIO-CRIME project - with support from the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) - conducted a scientific investigation on the topic of illegal small animal trade and the associated risk of pathogen transmission.

5 May 2021

Study uncovers protein 'signature' of severe COVID-19

Researchers at Massachusetts General Hospital have identified the protein "signature" of severe COVID-19, which they describe in a new study published in Cell Reports Medicine.

4 May 2021

Pathogen News and Research

Researchers identify six “words” used by specific immune cells to call up immune defense genes

Measuring metabolic 'fluxes' could help scientists advance new tuberculosis drugs

An Introduction to the Benefits of the Skin Trust Club

Case study describes consequences of undetected SARS-CoV-2 infection during mRNA vaccination

Lab reports 1st instance of SARS-CoV-2 variants affecting antigen test performance

Research suggests Pfizer-BioNTech COVID-19 vaccine reprograms innate immune responses

Researchers identify first biomarker to predict severity of COVID-19

SARS-CoV-2 main protease conformations are temperature-dependent

New research lays the groundwork for an effective salmonella vaccine

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

Bubonic plague had long-term impact on human immune genes, indicates study

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

Research shows how the world’s population has created an ideal breeding ground for infectious diseases

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

Prior MMR or Tdap vaccination may reduce risk of severe COVID-19

Scientists discover fundamental regulation mechanism of proteins

Mechano-immunological response to SARS-CoV-2

Study investigates the level of knowledge of young people and adolescents on "zoonotic diseases"

Study uncovers protein 'signature' of severe COVID-19

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