Polymerase Chain Reaction News and Research

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Polymerase chain reaction (PCR) is a revolutionary laboratory technique that enables the replication of a specific DNA sequence. Using PCR, millions of copies of a target DNA can be easily synthesized within a short period of time.

Human antibody response to SARS-CoV-2

A new study published on the preprint server medRxiv* in August 2020 reports on the human antibody response in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which is key to developing vaccines and managing the pandemic, as well as designing and executing serologic testing and interpreting their results.

1 Sep 2020

SARS-CoV-2 Neucleocapside (N) protein is heavily glycosylated

However, the nucleocapsid (N) protein is also extremely abundant and, therefore, a useful target for both vaccine and diagnostic test development. A new study published on the preprint server bioRxiv in August 2020 reveals the structure of this protein, a valuable step in using it for these purposes.

30 Aug 2020

Severe and fatal COVID-19 is rare in children

Now, a new study by researchers at the Universities of Edinburgh and Liverpool, Imperial College London, and the Royal Hospital for Children, Glasgow in the United Kingdom has shown that children and teenagers are less likely than adults to develop severe COVID-19 or die from the disease.

30 Aug 2020

FDA grants Abbott's COVID-19 rapid antigen test emergency-use authorization

Now, the U.S. Food and Drug Administration has granted emergency-use authorization to Abbott Laboratories for a $5 rapid-response COVID-19 antigen test, called BinaxNOW COVID-19 Ag Card, which is roughly the size of a credit card.

27 Aug 2020

Two viral gene targets needed in SARS-CoV-2 detection by PCR, say researchers

Researchers at the Chan Zuckerberg Biohub, San Francisco, and collaborators have warned against only targeting one viral gene when carrying out reverse transcriptase-polymerase chain reaction (RT-PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

27 Aug 2020

New sequencing approach can detect rare mutation in large number of cells

A sequencing approach can home in on a rare mutation within a large number of cells, revealing implications for CRISPR genome editing and early cancer detection.

27 Aug 2020

Ferrets not susceptible to SARS-CoV-2 infection

A recent study by scientists at the Cummings School of Veterinary Medicine at Tufts University has revealed that ferrets are not susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection even if they are directly exposed to symptomatic coronavirus disease 2019 (COVID-19) patients for a prolonged time.

24 Aug 2020

A better understanding of SARS-CoV-2 in children

Researchers at Duke University School of Medicine in Durham, North Carolina, have conducted a study showing that Hispanic ethnicity is associated with an increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children.

24 Aug 2020

Assessment of SARS-CoV-2 transmission on an airplane

As the COVID-19 pandemic continues to spread across the world, air travel restrictions are slowly being eased in some regions. Now, a new report published in the JAMA Network Open journal in August 2020 shows that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread among passengers on international flights unless proper precautions are taken.

23 Aug 2020

Raccoon dogs potential intermediate host for SARS-CoV-2

Researchers at the Friedrich Loeffler Institute in Germany have conducted a study demonstrating that raccoon dogs were a potential intermediate host in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

23 Aug 2020

Self-collected saliva and deep nasal swabs are equally effective for detecting SARS-CoV-2

Self-collected saliva and deep nasal swabs collected by healthcare providers are equally effective for detecting SARS-CoV-2, the virus that causes COVID-19, according to a new study conducted by ARUP Laboratories and University of Utah Health.

21 Aug 2020

Researchers validate novel flavivirus identification test

There are more than 70 species of flavivirus, and many cause diseases in humans and animals, including dengue, Zika and yellow fever viruses.

21 Aug 2020

No evidence of active SARS-CoV-2 in breastmilk of infected women

A recent study published in the journal JAMA in August 2020 suggests that SARS-CoV-2 RNA does not represent replication-competent virus and that breast milk may not be a source of infection for infants.

20 Aug 2020

Websites selling home-based COVID-19 testing kits providing inadequate or misleading information

In the UK and US, many websites are selling direct to user self-sampling and testing kits to detect SARS-CoV-2. Recently, a cross-sectional observational study was carried out to check the completeness and accuracy of information provided by these websites.

20 Aug 2020

Whey protein from human breastmilk inhibits SARS-CoV-2 infection

Many scientists have reported the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on pregnancy and the virus has been detected in breastmilk. Now a new study published on the preprint server bioRxiv* in August 2020 shows that whey protein in human breastmilk efficiently prevents infection with SARS-CoV-2 as well as post-entry viral replication.

20 Aug 2020

New prototype device non-invasively detects COVID-19 in exhaled breath of infected patients

Few people who have undergone nasopharyngeal swabs for coronavirus testing would describe it as a pleasant experience.

20 Aug 2020

Routine BCG immunization in infancy and COVID-19 containment in Japan

. A new study explores whether and how the practice of routine BCG vaccination of infants may have curbed the initial spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Japan. The research is published in the Journal of Infection.

19 Aug 2020

Chaotic and incoherent: Damning study of over 500 U.S. campus COVID-19 reopening plans

Now, a new study by researchers at California Institute of Technology and Johns Hopkins University and published on the preprint server medRxiv* in August 2020 shows that poorly planned and inadequate testing approaches to mitigate viral spread among the returning university students are likely to result in epidemics that will plague the country for a long time.

13 Aug 2020

SARS-CoV-2 viral load predicts risk of death

As the coronavirus pandemic evolved, there have been many developments in testing for the SARS-CoV-2 viral load in patients. Now, a team of researchers at the Icahn School of Medicine at Mount Sinai, New York, has found that the SARS-CoV-2 viral load can predict mortality in patients with coronavirus disease (COVID-19).

13 Aug 2020

A triplex SARS-CoV-2 assay based on nanopore sequencing is accurate, rapid and scalable

A novel breakthrough by a research group from Oxford Nanopore Technologies is a rapid way of testing and screening large numbers of samples for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

12 Aug 2020