Pathogen News and Research

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New testing technology can accurately differentiate between viral and bacterial infections

When patients complain of coughing, runny nose, sneezing and fever, doctors are often stumped because they have no fundamental tool to identify the source of the respiratory symptoms and guide appropriate treatments.

4 May 2021

ATS publishes new clinical practice guideline on community-acquired pneumonia

In its latest clinical practice guideline on community-acquired pneumonia the American Thoracic Society's guidelines panel addresses the use of nucleic acid-based testing for non-influenza viral pathogens.

4 May 2021

What happens in the first few days of SARS-CoV-2 infection?

New research, published in PLOS Biology, has evaluated SARS-CoV-2 infection in primary cultures of well-differentiated cells to determine how the virus affects the body and how the infection starts. Answers to these questions are essential to forming a general understanding of viral pathogenesis, which helps us develop effective prevention and treatment strategies for COVID-19.

4 May 2021

Can SARS-CoV-2’s impairment of endothelium cause vascular disease?

The study, published in the journal Circulation Research, suggests that COVID-19 is not only a respiratory disease but also a vascular disease. It highlights how the virus attacks the vascular system, causing endothelial impairment.

4 May 2021

Moderna COVID-19 vaccine makes it on WHO Emergency Use Listing

Moderna has announced Emergency Use Listing granted by the World Health Organization for its COVID-19 mRNA vaccine.

4 May 2021

Designing effective multidrug-resistant-TB treatments based on DNA sequencing

Globally, tuberculosis is the most common bacterial infectious disease leading to death. The pathogen causing tuberculosis, Mycobacterium tuberculosis, has a number of peculiarities. One is that it is growing very slowly.

3 May 2021

COVID-19 may not have appeared first in China, suggests new genomic study

A new study in Acta Mathematica Scientia suggests that the virus may have originated in multiple countries almost simultaneously, rather than spreading from China to the rest of the world.

3 May 2021

Class I HLA alleles shape CD8+ T cell repertoire in SARS-CoV-2 infection

An interesting new study discusses how adaptive cellular immunity against the SARS-CoV-2 is dependent on differences in HLA-encoding genes between patients.

3 May 2021

Discovery opens new avenues for developing antibody-based therapies for malaria

WEHI researchers have identified how natural human antibodies can block malaria parasites from entering red blood cells, potentially indicating how new protective therapies could be developed against this globally significant disease.

3 May 2021

As schools spend millions on air purifiers, experts warn of overblown claims and harm to children

Last summer, Global Plasma Solutions wanted to test whether the company's air-purifying devices could kill covid-19 virus particles but could find only a lab using a chamber the size of a shoebox for its trials. In the company-funded study, the virus was blasted with 27,000 ions per cubic centimeter.

3 May 2021

Comprehensive "cell atlas" shows how COVID-19 can lead to organ failure and death

Scientists from several hospitals and research centers have shown what happens in individual cells of patients who died of COVID-19. In a study published in Nature, the researchers describe how infected cells from multiple organs exhibited a range of molecular and genomic changes.

3 May 2021

Researchers develop a nanoparticle-based formulation with anti-SARS-CoV-2 activity

A study recently published in the journal Matter has demonstrated the development and validation of a nanoparticle-based formulation, capable of completely inhibiting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection blocking the interaction between viral spike protein and host cell angiotensin-converting enzyme 2 (ACE2).

3 May 2021

Could CRISPR be used as a SARS-CoV-2 antiviral?

The potential of using this gene manipulation technology as a SARS-CoV-2 inhibitor or prophylactic is investigated in a review recently uploaded to the journal Experimental Biology and Medicine (April 25th, 2021) by Arnab Banerjee and colleagues.

2 May 2021

Live "attenuated" influenza virus vaccine protects animals against respiratory infections, including SARS-CoV-2

Researchers in the United States and Austria have demonstrated the potential of a modified influenza virus as a vaccine to protect against viral respiratory pathogens, including the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19).

2 May 2021

Hepatitis C antivirals synergize with remdesivir to inhibit SARS-CoV-2 in vitro

A new study sheds light on the potential of drug combinations to stem viral transmission and treat patients with COVID-19. It also shows that four drugs used to treat hepatitis C synergize with remdesivir to make it up to ten times more effective at inhibiting SARS-CoV-2 in cell cultures.

30 Apr 2021

New study reveals mechanisms that result in lethal COVID-19

A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases.

30 Apr 2021

Human to animal transmission of SARS-CoV-2 in households is common

Coronaviruses are seen in multiple mammalian species. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, is said to have passed to humans from a mammalian source and to have originated from an animal reservoir as a zoonotic pathogen.

29 Apr 2021

Processed diets may promote diseases characterized by low-grade infection and inflammation

Processed diets, which are low in fiber, may initially reduce the incidence of foodborne infectious diseases such as E. coli infections, but might also increase the incidence of diseases characterized by low-grade chronic infection and inflammation such as diabetes, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

28 Apr 2021

Study observes increase in Lyme disease-causing ticks across California’s woodlands and beaches

US-based researchers – at Colorado State University and the Northern Arizona University – have discovered that disease-causing ticks are finding their way onto beachfront properties, including infestations in woodlands and beaches around North California.

28 Apr 2021

Novel platform has potential to detect many disease-related biomarkers in just one test

Most conventional molecular diagnostics usually detect only a single disease-related biomarker. Great examples are the PCR tests currently used to diagnose COVID-19 by detecting a specific sequence from SARS-CoV-2.

28 Apr 2021

Pathogen News and Research

New testing technology can accurately differentiate between viral and bacterial infections

ATS publishes new clinical practice guideline on community-acquired pneumonia

What happens in the first few days of SARS-CoV-2 infection?

Can SARS-CoV-2’s impairment of endothelium cause vascular disease?

Moderna COVID-19 vaccine makes it on WHO Emergency Use Listing

Designing effective multidrug-resistant-TB treatments based on DNA sequencing

COVID-19 may not have appeared first in China, suggests new genomic study

Class I HLA alleles shape CD8+ T cell repertoire in SARS-CoV-2 infection

Discovery opens new avenues for developing antibody-based therapies for malaria

As schools spend millions on air purifiers, experts warn of overblown claims and harm to children

Comprehensive "cell atlas" shows how COVID-19 can lead to organ failure and death

Researchers develop a nanoparticle-based formulation with anti-SARS-CoV-2 activity

Could CRISPR be used as a SARS-CoV-2 antiviral?

Live "attenuated" influenza virus vaccine protects animals against respiratory infections, including SARS-CoV-2

Hepatitis C antivirals synergize with remdesivir to inhibit SARS-CoV-2 in vitro

New study reveals mechanisms that result in lethal COVID-19

Human to animal transmission of SARS-CoV-2 in households is common

Processed diets may promote diseases characterized by low-grade infection and inflammation

Study observes increase in Lyme disease-causing ticks across California’s woodlands and beaches

Novel platform has potential to detect many disease-related biomarkers in just one test

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