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Study investigates gene expression signature to predict response to bevacizumab

A new test may help identify newly diagnosed glioblastoma patients more likely to benefit from bevacizumab (Avastin-), according to new research from The University of Texas MD Anderson Cancer Center.

3 Jun 2013

Human tumors with MET amplification respond to MET inhibitor drugs

A subset of colorectal cancers responds to anti-epidermal growth factor receptor (anti-EGFR) therapies, but develops resistance within months. Among cancers that develop resistance to anti-EGFR therapy, some showed overexpression of a gene called MET, according to a study published in the June issue of Cancer Discovery, a journal of the American Association for Cancer Research.

3 Jun 2013

Study finds HER2 irregularities in 14 different advanced solid tumors

The HER2 growth-factor gene is known to be over-active in breast and gastro-esophageal cancers. But now, irregularities in the genes's expression - among them mutations, amplifications, substitutions, and translocations - have been found in 14 different advanced solid tumors.

3 Jun 2013

Mount Sinai researchers present landmark studies at ASCO meeting

Icahn School of Medicine at Mount Sinai researchers will present several landmark studies at the 2013 American Society of Clinical Oncology meeting May 31-June 4, 2013 in Chicago, including data on the likelihood of spousal human papillomavirus oral infection, new gene signatures in melanoma, and issues with high readmission rates after cancer surgery.

3 Jun 2013

Glioblastoma patients treated with bevacizumab have deterioration in neurocognitive function

Many glioblastoma patients treated with bevacizumab (Avastin-) have significant deterioration in neurocognitive function, symptoms and quality of life. Not only that, the changes often predict treatment outcomes, according to new research from The University of Texas MD Anderson Cancer Center.

1 Jun 2013

Researchers discover potential biomarkers to identify patients with head and neck cancer

Researchers from Fox Chase Cancer Center will present data at the 49th Annual Meeting of the American Society of Clinical Oncology on Saturday, June 1, which shows the discovery of potential biomarkers that may be used to identify patients with head and neck cancer whose tumors are unlikely to respond to treatment by the targeted therapy cetuximab-a type of monoclonal antibody.

1 Jun 2013

Transplantation of human stem cells improves muscle function in rats used to model ALS

Transplantation of human stem cells in an experiment conducted at the University of Wisconsin-Madison improved survival and muscle function in rats used to model ALS, a nerve disease that destroys nerve control of muscles, causing death by respiratory failure.

29 May 2013

New study could help increase survival rates of people with colorectal tumours

Researchers from London's Kingston University have begun a two-year study which could help prolong the lives of people with colorectal tumours.

24 May 2013

Study suggests possible way to halt cancer development in premalignant cells

Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant-cells on the cusp between normalcy and cancers-which may lead to new methods of stopping tumors.

24 May 2013

EGFR gums up cell's miRNA-processing machinery under oxygen starvation conditions

Even while being dragged to its destruction inside a cell, a cancer-promoting growth factor receptor fires away, sending signals that thwart the development of tumor-suppressing microRNAs before it's dissolved, researchers reported in an early online publication at Nature.

24 May 2013

Obesity directly tied to several cancers

"Obesity is a major risk factor for developing cancer, roughly the equivalent of tobacco use, and both are potentially reversible. Further, obese cancer patients do worse in surgery, with radiation or on chemotherapy - worse by any measure." Karen Basen-Engquist, Ph.D., Director of MD Anderson's new Center for Energy Balance in Cancer Prevention and Survivorship and professor of Behavioral Science.

22 May 2013

Emory University researchers identify a protein that stimulates orphan receptors in the brain

Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological diseases.

22 May 2013

Study: VEGF inhibitor appears to improve glaucoma surgical outcomes

The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggested that vascular endothelial growth factor (VEGF) activates fibrosis, whereas VEGF inhibition results in reduced scar formation and better surgical results.

18 May 2013

Researchers demonstrate how EGF accelerates division of cell nucleus

Biologists at Heidelberg University have discovered new approaches for the treatment of cancer. They investigated how a special signalling molecule, the epidermal growth factor (EGF), stimulates the separation of chromosomes in the cell. The researchers were able to demonstrate that EGF accelerates the division of the cell nucleus, i.e. mitosis, as well as boosts precision in chromosome segregation.

15 May 2013

Cancers physically alter cells in lymphatic system to promote the spread of disease

Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system - a network of vessels that transports and stores immune cells throughout the body - to promote the spread of disease, a process called metastasis.

14 May 2013

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.

10 May 2013

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

In cancer, mutations in proteins that control cell growth are common, leading to unrestrained cellular proliferation and tumor formation.

9 May 2013

Growth Factor News and Research

Study investigates gene expression signature to predict response to bevacizumab

Human tumors with MET amplification respond to MET inhibitor drugs

Study finds HER2 irregularities in 14 different advanced solid tumors

Mount Sinai researchers present landmark studies at ASCO meeting

Glioblastoma patients treated with bevacizumab have deterioration in neurocognitive function

Researchers discover potential biomarkers to identify patients with head and neck cancer

Transplantation of human stem cells improves muscle function in rats used to model ALS

New study could help increase survival rates of people with colorectal tumours

Study suggests possible way to halt cancer development in premalignant cells

EGFR gums up cell's miRNA-processing machinery under oxygen starvation conditions

Obesity directly tied to several cancers

Emory University researchers identify a protein that stimulates orphan receptors in the brain

Study: VEGF inhibitor appears to improve glaucoma surgical outcomes

Researchers demonstrate how EGF accelerates division of cell nucleus

Cancers physically alter cells in lymphatic system to promote the spread of disease

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

Patients with ASPS appear to benefit from anti-cancer drug, cediranib

Seven-year quest to understand how breast cancer cells resist treatment

Prior administration of erythropoietin reduces need for blood transfusions

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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