Efficacy News and Research

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Speech analysis phone app could identify early signs of hepatic encephalopathy

Research from the University of Michigan suggests that one day a phone app could be able to detect the development of hepatic encephalopathy in patients just by listening to them speak.

18 Sep 2024

Early intervention in pediatric-onset MS can lead to improved long-term outcomes

New research presented today at ECTRIMS 2024 reveals that initiating monoclonal antibody therapy during childhood, rather than delaying treatment until early adulthood, significantly reduces long-term disability in multiple sclerosis (MS) patients.

18 Sep 2024

$1 million grant awarded to explore myelin repair mechanisms in multiple sclerosis

The National Multiple Sclerosis Society (USA) has awarded a grant of 1 million dollars to Dr. Isabel Pérez-Otaño, who leads the Plasticity and Remodeling of Neural Circuits laboratory at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche.

18 Sep 2024

Lipid molecule fuels cancer growth

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes. Once alerted, the body's defenses can swoop in, destroying rogue cells before they can do much damage. Lying at the heart of this early warning system are lipids, fatty compounds previously seen by cancer biologists primarily as a fuel source for burgeoning tumors.

18 Sep 2024

Microbial-immune interactions in severe asthma: Insights into pathogen dominance and treatment approaches

Researchers assess the airway microbiome and host immune-inflammatory responses to identify treatable aspects of severe asthma.

17 Sep 2024

$4.1 million funding supports epilepsy treatment research using spider venom proteins

UQ researchers have received $4.1 million from the Medical Research Future Fund to advance their research into epilepsy treatments made from spider venom proteins.

17 Sep 2024

Semaglutide vs. liraglutide: One-year weight loss efficacy in obesity and type 2 diabetes

Researchers compare the weight loss efficacy of injectable liraglutide and semaglutide.

17 Sep 2024

Newcells Biotech launches high-content and high-throughput imaging suite to advance pre-clinical drug development programmes

Newcells Biotech (“Newcells”), a leading drug discovery partner specialising in the development of in vitro models and bespoke assay services to improve the prediction of in vivo human outcomes, today announced the launch of its imaging suite and advanced lung Fibroblast-to-Myofibroblast Transition (FMT) assay.

From Newcells Biotech 17 Sep 2024

MicrosensDx collaborates with Imperial researchers to develop groundbreaking sepsis test

MicrosensDx is excited to announce that it is working with The Mayr Group at Imperial College London to develop a novel biomarker test for the early recognition of sepsis.

From MicrosensDx 17 Sep 2024

Study highlights limited evidence for antidepressants in treating pain in older adults

University of Sydney research has found people over 65 are being prescribed antidepressants as pain treatment based on international guidelines that use limited evidence.

16 Sep 2024

ESMO 2024: Promising results in immunotherapy and antibody drug conjugates for gynecological cancers

Studies reported at ESMO 2024 reveal new groups of women with early-stage endometrial and cervical cancers who gain clinically meaningful benefit from adding immunotherapy to current standard treatments, while a first-in-human study found 'promising' antitumor activity with a novel antibody drug conjugate (ADC) targeting the protein claudin 6 in heavily pretreated patients with ovarian and endometrial cancers.

16 Sep 2024

Novel delivery platform enhances effectiveness of cancer immunotherapy and reduces side effects

Immunotherapy is a type of cancer treatment that uses the body's own immune system to help fight cancer. This is by stimulating the immune response to recognize and attack cancer cells more effectively.

16 Sep 2024

Review highlights mitochondrial dysfunction in cholestatic liver injury

Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the digestion and absorption of fats.

16 Sep 2024

Combination immunotherapy yields 10-year survival for metastatic melanoma patients

Long-term data from a landmark international trial show about half of patients with metastatic melanoma treated with a combination of immune checkpoint inhibitors survive cancer-free for 10 years or more, according to a new report from Weill Cornell Medicine and Dana-Farber Cancer Center investigators and their colleagues.

16 Sep 2024

Laughter is as good as eye drops in soothing dry eyes, study finds

A study reveals laughter exercise is as effective as artificial tears for dry eye disease, improving symptoms and tear film stability without adverse effects.

16 Sep 2024

Early data shows mRNA-4359 may benefit patients with advanced solid cancers

Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.

16 Sep 2024

Antibody-drug conjugate shows promise in treating ovarian and endometrial cancers

14 Sep 2024

New cancer drug shows encouraging results in Phase I/II trial

The antibody-drug conjugate (ADC) puxitatug samrotecan (AZD8205) demonstrated a manageable safety profile consistent with similar ADCs and initial efficacy in heavily pretreated patients with advanced or metastatic solid tumors, according to interim data shared today at the 2024 European Society for Medical Oncology (ESMO) Congress by researchers from The University of Texas MD Anderson Cancer Center.

14 Sep 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

Evolution of vaccine adjuvants from empirical discovery to rational design

Vaccine adjuvants have evolved significantly since their inception, transitioning from empirical discovery to a more structured approach grounded in rational drug design.

13 Sep 2024

Efficacy News and Research

Speech analysis phone app could identify early signs of hepatic encephalopathy

Early intervention in pediatric-onset MS can lead to improved long-term outcomes

$1 million grant awarded to explore myelin repair mechanisms in multiple sclerosis

Lipid molecule fuels cancer growth

Microbial-immune interactions in severe asthma: Insights into pathogen dominance and treatment approaches

$4.1 million funding supports epilepsy treatment research using spider venom proteins

Semaglutide vs. liraglutide: One-year weight loss efficacy in obesity and type 2 diabetes

Newcells Biotech launches high-content and high-throughput imaging suite to advance pre-clinical drug development programmes

MicrosensDx collaborates with Imperial researchers to develop groundbreaking sepsis test

Study highlights limited evidence for antidepressants in treating pain in older adults

ESMO 2024: Promising results in immunotherapy and antibody drug conjugates for gynecological cancers

Novel delivery platform enhances effectiveness of cancer immunotherapy and reduces side effects

Review highlights mitochondrial dysfunction in cholestatic liver injury

Combination immunotherapy yields 10-year survival for metastatic melanoma patients

Laughter is as good as eye drops in soothing dry eyes, study finds

Early data shows mRNA-4359 may benefit patients with advanced solid cancers

Antibody-drug conjugate shows promise in treating ovarian and endometrial cancers

New cancer drug shows encouraging results in Phase I/II trial

Scientists develop novel technique to combat T cell exhaustion

Evolution of vaccine adjuvants from empirical discovery to rational design

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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