Metabolites News and Research

RSS

New mass spectrometry imaging protocol allows analysis of metabolite composition of tissues

In biomedical research, working with tissue samples is indispensable because it permits insights into the biological reality of patients, for example, in addition to those gained from Petri dishes and computer simulations.

18 Jul 2016

Rare antibiotic compound detected in fungi for first time

Besides mushrooms such as truffles or morels, also many yeast and mould fungi, as well as other filamentous fungi belong to the Ascomycota phylum. They produce metabolic products which can act as natural antibiotics to combat bacteria and other pathogens. Penicillin, one of the oldest antibiotic agents, is probably the best known example.

18 Jul 2016

Food chemists find garlic aroma in breast milk of women who have consumed garlic

Food chemists at Friedrich-Alexander-Universität Erlangen-Nürnberg have found that garlic aroma is evident in the breast milk of women who have consumed garlic.

15 Jul 2016

Study reveals problems encountered when trying to avoid plastic exposure

The well-known documentary "Plastic Planet" by Werner Boote starkly illustrates the dangers of plastic and synthetics for human beings and also shows how ubiquitous plastic is.

13 Jul 2016

Tiny micro-vesicle structures may help predict probability of developing Alzheimer's dementia

Researchers at University of California San Diego School of Medicine say tiny micro-vesicle structures used by neurons and other cells to transport materials internally or dispose of them externally carry tell-tale proteins that may help to predict the likelihood of mild cognitive impairment (MCI) developing into full-blown Alzheimer's disease (AD).

6 Jul 2016

Study demonstrates role of leukocyte activation receptor CD69 in development of psoriasis

Scientists at the Centro de Investigaciones Cardiovasculares Carlos III have defined the key role of an immune-system receptor in the development of psoriasis, suggesting that it could serve as a therapeutic target for the control of this disease.

5 Jul 2016

AHR plays role in modulating the body's innate immune response to viral infections

A receptor, first known for its role in mediating the harmful effects of the environmental pollutant dioxin in our body, is now understood to play other important roles in modulating the innate immune response.

1 Jul 2016

Scientists reveal metabolic reasons why low calorie diets may lead to longer life

Overeating can lead to health issues that can shorten one's life, such as obesity, diabetes and heart disease.

30 Jun 2016

Scientists discover link between two genes involved in PD and autoimmune diseases

A study publish in the journal CELL indicates that two genes associated with Parkinson's disease (PD) are key regulators of the immune system, providing direct evidence linking Parkinson's to autoimmune disease.

27 Jun 2016

Simple method may help predict type 2 diabetes risk in women with gestational diabetes

An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.

23 Jun 2016

Lack of Alix protein leads to occurrence of hydrocephalus in the brain

A team led by researchers at St. Jude Children's Research Hospital report that mice lacking the protein Alix develop hydrocephalus or "water on the brain." Alix ensures that epithelial cells of the choroid plexus are oriented correctly with respect to one another to prevent compromise of the epithelial barrier.

23 Jun 2016

Researchers develop plasma QC assay for downstream metabolomics applications

Researchers from IBBL and the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have investigated the impact of variations in temperature and delays during blood sample processing on downstream metabolomics applications.

22 Jun 2016

Researchers reveal how cancer cells use energy to move and divide so quickly

Cancer cells and normal cells both divide and move, but with cancer cells it's like they're on steroids: everything is bigger, faster, more.

15 Jun 2016

Researchers unravel species-function relationships in gut microbial genomes

Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under investigated. Using a manually curated metabolic module framework for (meta-)genomic data analysis, Sara Vieira-Silva, Gwen Falony and colleagues from the Jeroen Raes lab studied species-function relationships in gut microbial genomes and microbiomes.

14 Jun 2016

Tackling Healthcare Challenges in a Changing World: an Interview with Professor Jeremy Nicholson

As individuals and as populations our risks of getting diseases are determined partly genetically and partly from the environment that we live in. An important part of that environment that mediates between the outside world and the inside world of our bodies is the microbiome.

10 Jun 2016

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

Professor Claudio Luchinat, University of Florence and co-founder of the Magnetic Resonance Center (CERM), speaks to News-Medical about his research in NMR-based metabolomics.

From Bruker BioSpin Division 9 Jun 2016

Mathematical approach can help achieve optimal dosing for various drugs

In treating diseases with drugs, dosing is critical; too little is ineffective, while too much can be lethal. Colorado State University's Brad Reisfeld takes a mathematical approach to achieving optimal dosing for various drugs.

9 Jun 2016

MetaboBASE personal libraryTM introduced by Bruker

At ASMS 2016, Bruker announces a new mass spectral library called Bruker MetaboBASE Personal LibraryTM, which contains high-resolution, accurate mass MS/MS spectra of over 13,000 metabolic compounds for the seamless identification of metabolites.

From Bruker Daltonics 7 Jun 2016

Analysing blood metabolites may help monitor effects of novel drugs

Testing for metabolic changes in the blood could indicate whether a cancer drug is working as designed, a new study reports.

3 Jun 2016

Gut microbe's metabolite butyrate hampers intestinal repair from IBD

Intestinal stem cells are among the most rapidly dividing cells in the body, busily creating new cells to replace the ones that are constantly being sloughed off. But unlike stem cells elsewhere in the body, those in the intestine are hidden away, and for good reason, it turns out.