Glucocorticoid News and Research

RSS

Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).

Combined glucocorticoid and antioxidant therapy could benefit premature babies

Scientists at the University of Cambridge have suggested that subtle changes to the drugs administered to mothers threatened with preterm birth or to premature babies could further improve clinical treatment and help increase their safety.

21 Mar 2019

Increased stress hormones accelerate breast cancer metastasis

It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones.

14 Mar 2019

Study elucidates mechanism behind development of steroid diabetes

Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout the body, how these adverse effects are caused and by which organ are not well understood.

28 Feb 2019

Study findings hold promise for children with DMD

Prednisone, the current standard of care used to treat kids with Duchenne muscular dystrophy (DMD), reduces chronic inflammation but has harsh side effects.

11 Feb 2019

Scientists pinpoint mechanism that leads to steroid diabetes

Patients undergoing long-term treatment with steroids may suffer from metabolic side effects. Researchers at the Helmholtz Zentrum München and the Ludwig Maximilians University of Munich, partners in the German Center for Diabetes Research, have now pinpointed a mechanism that leads to so-called steroid diabetes

25 Jan 2019

New CU Boulder study shows how spinal injury impacts circadian rhythms

In the hours and days following a spinal cord injury, the gears that control the body's internal clocks fall profoundly out of sync, impacting body temperature, hormone fluctuation, immunity and the timing of a host of other bodily processes, according to new University of Colorado Boulder research.

5 Dec 2018

Binge drinking history makes male and female mice react differently to stress, study shows

Researchers with the Veterans Affairs Portland Health Care System and Oregon Health & Sciences University found that a history of binge drinking made male and female mice react differently to traumatic stress.

10 Oct 2018

Breastfeeding changes gene activity that regulates infant's response to stress

It has long been known that there are many physical and mental health benefits of breastfeeding for mothers and babies. But can these benefits be due to genetic changes induced by breastfeeding? New research suggests that connection.

27 Sep 2018

New guidance for treatment of bone loss in hematologic stem cell transplant Recipients

Hematopoietic stem cell transplantation is the treatment of choice for many patients with malignant and non-malignant hematological diseases, such as leukemia and multiple myeloma. The success of recent advances in such transplantation techniques and supportive care measures, has led to greater numbers of long-term HSCT survivors.

20 Sep 2018

Brief yet acute stressors have lasting effects, study finds

Little is known about how brief yet acute stressors – such as war, natural disasters and terror attacks – affect those exposed to them, though human experience suggests they have long-term impacts.

29 Aug 2018

Ferring announces FDA approval of ZOMACTON for injection in four new pediatric indications

Ferring Pharmaceuticals Inc. today announced that the U.S. Food and Drug Administration has approved ZOMACTON for injection in four additional pediatric indications

20 Jul 2018

Phase 2 study of dexpramipexole in hypereosinophilic syndromes meets its co-primary endpoints

Knopp Biosciences LLC today announced the publication of a report in the journal Blood that a Phase 2 study of dexpramipexole in hypereosinophilic syndromes met its co-primary endpoints.

10 May 2018

New treatment option appears promising for patients with glucocorticoid-induced osteoporosis

About one in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. However, glucocorticoids, such as prednisone, have a side effect -- they induce the bone loss called osteoporosis, causing an estimated yearly bone fracture rate of 5 percent.

27 Apr 2018

Early life stress impacts how the sensory systems develop, review shows

Life needs stimulation. However, overstimulation can cause exhaustion and illness. During specific sensitive periods early in life, stress can even affect later mental health.

16 Apr 2018

LSD1 enzyme regulates skeletal muscle differentiation and metabolic activity

Our bodies convert food into energy for all life activities. These metabolic processes allow the cells that make up our bodies to produce (anabolism) and consume (catabolism) energy molecules from nutrients.

12 Apr 2018

Study shows impact of prenatal stress on offspring stress hormone levels

Vertebrate species, including humans, exposed to stress prenatally tend to have higher stress hormones after birth, according to a new Dartmouth-led study published in Scientific Reports.

11 Apr 2018

Mother's stress during pregnancy changes brain connectivity in-utero

The time babies spend in the womb is far from idle. The brain is changing more rapidly during this time than at any other time in development. It is an active time for the fetus to grow and explore, and of course connect to its mother.

26 Mar 2018

New findings yield insights into factors that contribute to aggressive endometrial tumors

New research from Huntsman Cancer Institute at the University of Utah indicates steroid and hormone receptors are simultaneously active in many endometrial cancer tissues.

13 Mar 2018

New guidelines intend to provide template for optimal, most up-to-date DMD care

Diagnostic and treatment advances are helping patients with Duchenne muscular dystrophy - one of nine major types of muscular dystrophy that affects males - live into their 30s and beyond, raising challenges in such areas as education, vocation, levels of independence, personal relationships, emotional health, and intimacy.

13 Mar 2018

Researchers reveal new molecular target to help ease asthma symptoms

Researchers at UC Davis Health and Albany Medical College have shown that the protein vascular endothelial growth factor A -- or VEGFA -- plays a major role in the inflammation and airway obstruction associated with asthma.

7 Mar 2018