Hepatology News and Research

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Hepatology is the branch of medicine that incorporates study of liver, gallbladder, biliary tree and pancreas as well as management of their disorders.

Novel classification system for SJS/TEN aims to improve patient care

First identified by Stevens and Johnson in 1922, SJS and TEN are now recognized as disorders with a continuum of severity, from milder forms (SJS) to the most severe (TEN).

19 Feb 2025

Novel therapeutic approaches targeting the Wnt pathway in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates.

19 Feb 2025

IgG-guided diet outperforms sham diet in clinical trial

Michigan Medicine and Cleveland Clinic researchers have found that patients with irritable bowel syndrome were more likely to experience less abdominal pain if they followed a diet guided by the results of a blood test, compared to those who followed a sham elimination diet.

13 Feb 2025

Study explores microbiome reboot to prolong effect of Crohn's disease therapy

A special liquid diet, known as exclusive enteral nutrition, is an essential therapy for Crohn's disease. Patients consume only this formula for six to eight weeks, completely avoiding solid foods. However, the exact reasons why this is helpful were previously unclear.

11 Feb 2025

New minimally invasive treatment offers hope for primary aldosteronism

Doctors at Queen Mary University of London, Barts Health NHS Trust, and University College London have led the development of a simple, minimally invasive Targeted Thermal Therapy (Triple T) that has the potential to transform medical management of a common, but commonly overlooked, cause of high blood pressure.

10 Feb 2025

Targeted Thermal Therapy could transform management of common cause of high blood pressure

8 Feb 2025

Liver graft preservation methods alter microbiota composition after transplantation

End-stage liver disease is associated with disruptions in gut microbiota composition and function, which may facilitate gut-to-liver bacterial translocation, impacting liver graft integrity and clinical outcomes following liver transplantation.

7 Feb 2025

Alcohol and preexisting health conditions raise risk of advanced liver disease

Why do some people who consume a few glasses of alcohol a day develop advanced liver disease while others who drink the same amount don't?

7 Feb 2025

HMB supplement trial explores new treatment for chronic liver disease

A dietary supplement used to build muscle – or prevent muscle loss as a result of ageing or illness – is to be trialled as a potential treatment for chronic liver disease.

28 Jan 2025

Antihistamines offer new hope for erythropoietic protoporphyria-related liver disease

Chlorcyclizine shows promise in reducing protoporphyrin-IX accumulation and liver damage in erythropoietic protoporphyria, targeting histamine pathways.

20 Jan 2025

Evaluating biomarkers for diagnosing minimal hepatic encephalopathy in cirrhotic patients

The performance of neurodegenerative biomarkers-neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau, and ubiquitin carboxy-terminal hydrolase L1 (UCHL1)-in diagnosing minimal hepatic encephalopathy (MHE) has not been systematically evaluated, simultaneously, nor have their associations with the development of overt hepatic encephalopathy (OHE).

17 Jan 2025

New rabbit model provides insights into CF-related pancreatic endocrine pathology

Cystic fibrosis (CF) is a life-threatening genetic disease affecting multiple organ systems, with pancreatic dysfunction representing a critical and often overlooked complication.

17 Jan 2025

SOX9 overexpression protects against lipid accumulation in MASH via AMPK activation

The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development.

17 Jan 2025

Study evaluates effectiveness and safety of TMF for chronic hepatitis B

Chronic hepatitis B (CHB) remains a significant global health challenge, and effective antiviral therapies are essential for long-term management.

17 Jan 2025

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in PTPN2.

17 Jan 2025

Alcohol consumption increases risks of cirrhosis and HCC in patients with HBV infection

The quantitative effects of alcohol consumption on cirrhosis and hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) infection are unknown.

16 Jan 2025

Antihistamine shows promise for treating rare genetic liver disease

A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ultimately require transplantation, according to new research from Rutgers Health.

16 Jan 2025

Genetic risk factor linked to increased susceptibility to SARS-CoV-2 infection

Researchers have identified a novel genetic risk factor for SARS-CoV-2 infection, providing new insights into the virus' ability to invade human cells. SARS-CoV-2 is the virus that spreads COVID-19.

15 Jan 2025

New prediction model improves early detection of infected pancreatic necrosis

A new prediction model for infected pancreatic necrosis (IPN) in patients with acute pancreatitis (AP) offers a groundbreaking approach to improving patient outcomes.

20 Dec 2024

Understanding the mechanisms behind alcohol-associated liver disease

A newly published review in eGastroenterology compiles recent research on alcohol-associated liver disease (ALD), offering an overview of its pathogenesis and efforts to better understand this condition.

19 Dec 2024

Hepatology News and Research

Further Reading

Novel classification system for SJS/TEN aims to improve patient care

Novel therapeutic approaches targeting the Wnt pathway in hepatocellular carcinoma

IgG-guided diet outperforms sham diet in clinical trial

Study explores microbiome reboot to prolong effect of Crohn's disease therapy

New minimally invasive treatment offers hope for primary aldosteronism

Targeted Thermal Therapy could transform management of common cause of high blood pressure

Liver graft preservation methods alter microbiota composition after transplantation

Alcohol and preexisting health conditions raise risk of advanced liver disease

HMB supplement trial explores new treatment for chronic liver disease

Antihistamines offer new hope for erythropoietic protoporphyria-related liver disease

Evaluating biomarkers for diagnosing minimal hepatic encephalopathy in cirrhotic patients

New rabbit model provides insights into CF-related pancreatic endocrine pathology

SOX9 overexpression protects against lipid accumulation in MASH via AMPK activation

Study evaluates effectiveness and safety of TMF for chronic hepatitis B

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Alcohol consumption increases risks of cirrhosis and HCC in patients with HBV infection

Antihistamine shows promise for treating rare genetic liver disease

Genetic risk factor linked to increased susceptibility to SARS-CoV-2 infection

New prediction model improves early detection of infected pancreatic necrosis

Understanding the mechanisms behind alcohol-associated liver disease

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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