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Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in children (MIS-C) following acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

12 Apr 2022

mRNA vaccines induce CD8+ T cells that may reduce COVID-19 severity

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-specific cluster of differentiation 8 (CD8+) T cell responses.

12 Apr 2022

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Researchers identified mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoproteins (NP) epitope flanking regions and their potential effects on CD8+ T cell activation.

12 Apr 2022

NVX-CoV2373 vaccine found to induce functional SARS-CoV-2-specific T cell responses

In a recent study researchers evaluated the T cell responses elicited by full-length severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein vaccine NVX-CoV2373.

12 Apr 2022

Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

Researchers tested whether a subunit vaccine could generate mucosal immunity in mice and prevent SARS-CoV-2 infection and related pathology.

11 Apr 2022

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea.

8 Apr 2022

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

In a new study, researchers characterized over 100 SARS-CoV-2-specific CD4+ T-cell epitopes.

8 Apr 2022

Role of SARS-CoV-2 S1 subunit in severe COVID-19

A new study aimed to determine whether portions of the SARS-CoV-2 spike protein are capable of activating innate immune cells like Gal-3.

30 Mar 2022

Study investigates room-temperature stable, self-amplifying RNA vaccine against SARS-CoV-2

Researchers applied a previously developed thermostable self-amplifying ribonucleic acid vaccine to COVID-19.

28 Mar 2022

Monoclonal antibodies found to prevent lung inflammation in SARS-CoV-2-Omicron-infected mice

Researchers investigated how monoclonal antibodies, S309 and AZD7442, reduced lung infection in mice infected with the SARS-CoV-2 new variant of concern Omicron's BA.1, BA.1.1, and BA.2 sublineages.

23 Mar 2022

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Researchers assessed the impact of recombinant accessory protein-deficient severe acute respiratory syndrome coronavirus 2 immunization against SARS-CoV-2 transmission and disease severity.

18 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

BNT162b2 booster vaccination induces robust humoral and cellular immune responses

Scientists evaluate the humoral and cellular immune responses in individuals who have received a third booster dose of mRNA-based COVID-19 vaccine.

17 Mar 2022

The immunogenicity of homologous and heterologous boosters in adults who received inactivated COVID-19 vaccine six months prior

Researchers compared the efficacy of booster doses of heterologous intramuscular and aerosolized adenovirus-vectored vaccine, a recombinant protein-based ZF2001 vaccine, and homologous CoronaVac vaccines.

17 Mar 2022

The Future of Tuberculosis; An Interview with the Bill & Melinda Gates Medical Research Institute

We speak to Dr. Alemnew Dagnew from the Bill & Melinda Gates Medical Research Institute, about their tuberculosis vaccine study and the future of tuberculosis.

16 Mar 2022

Good glycemic control in SARS-CoV-2 vaccinated type 2 diabetic patients reduces risk of breakthrough infection

Adequate glycemic control during the year after being vaccinated against the SARS-CoV-2 improves the relative immunological response.

15 Mar 2022

Comparative immunogenicity of reduced and standard BNT162b2 and mRNA-1273 boosters in CoronaVac vaccinees

Researchers compared the immunogenicity of the reduced and standard doses of the BNT162b2 and mRNA-1273 vaccine in adults immunized with two doses of the CoronaVac vaccine.

8 Mar 2022

CD4 T-cell immunity active six months into COVID-19 convalescence

A new paper explores the presence of CD4 T-cell-mediated adaptive immunity against SARS-CoV-2 in late convalescence.

6 Mar 2022

T-cell cytokine and fatty acid work together to trigger a type of cell death

Researchers at the University of Michigan Rogel Cancer Center found that a cytokine, a category of protein that acts as messengers in the body, and a fatty acid can work together to trigger a type of cell death previously defined by studies with synthetic molecules.

4 Mar 2022

Study explores the impact of COVID-19 on pancreatic cells

New study findings showed that SARS-CoV-2 caused a productive yet restricted infection of pancreatic islet cells and an insignificant inflammatory response.

23 Feb 2022

Interferon gamma News and Research

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

mRNA vaccines induce CD8+ T cells that may reduce COVID-19 severity

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

NVX-CoV2373 vaccine found to induce functional SARS-CoV-2-specific T cell responses

Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

Role of SARS-CoV-2 S1 subunit in severe COVID-19

Study investigates room-temperature stable, self-amplifying RNA vaccine against SARS-CoV-2

Monoclonal antibodies found to prevent lung inflammation in SARS-CoV-2-Omicron-infected mice

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Innate and adaptive immune responses to BNT162b2 vaccination in mice

BNT162b2 booster vaccination induces robust humoral and cellular immune responses

The immunogenicity of homologous and heterologous boosters in adults who received inactivated COVID-19 vaccine six months prior

The Future of Tuberculosis; An Interview with the Bill & Melinda Gates Medical Research Institute

Good glycemic control in SARS-CoV-2 vaccinated type 2 diabetic patients reduces risk of breakthrough infection

Comparative immunogenicity of reduced and standard BNT162b2 and mRNA-1273 boosters in CoronaVac vaccinees

CD4 T-cell immunity active six months into COVID-19 convalescence

T-cell cytokine and fatty acid work together to trigger a type of cell death

Study explores the impact of COVID-19 on pancreatic cells

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