Metabolic Disease News and Research

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Gene therapy reverses cardiac dysfunction in mice with Barth syndrome

Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. It can cause life-threatening heart failure and also weakens the skeletal muscles, undercuts the immune response, and impairs overall growth.

9 Mar 2020

Sex-specific differences in the immune system may explain men's susceptibility to obesity

Melbourne researchers have uncovered important differences between the male and female immune system which may explain why men are more susceptible to obesity and metabolism-related associated diseases, such as heart disease, stroke and diabetes.

26 Feb 2020

High testosterone in women ups risk for cancer, diabetes, and metabolic disease

Testosterone is a steroid hormone that triggers the development of male secondary sex characteristics. Though found mainly in men, the ovaries in women release small amounts of testosterone. When combined with estrogen, testosterone aids in the growth and repair of a woman's reproductive tissues.

12 Feb 2020

Long noncoding RNA can protect our metabolism against metabolic complications

Unlike what we commonly refer to as 'genes', these phantom genes or 'Long noncoding RNA' (LncRNAs) do not lead to the production of proteins that our cells, and thus our entire bodies are made of.

31 Jan 2020

Research uncovers disease-aggravating mutation in mouse model of GRACILE syndrome

The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. This discovery provides a new tool for studies of mitochondrial diseases.

29 Jan 2020

Time to include standard care screenings for diagnosis of pre-symptomatic type 1 diabetes

Researchers at Helmholtz Zentrum München employed the world's first early detection test for type 1 diabetes in a large-scale population study in Bavaria, Germany, and investigated its effects.

29 Jan 2020

New stigma-reduction intervention benefits obese individuals who struggle with poor self-image

People with obesity are often treated with less respect than other people, discriminated against, and socially devalued because of their weight.

24 Jan 2020

Persistant industrial chemical modifies gut microbiome of mice

An industrial chemical -- phased out since 2002, but previously used in stain and water-repellent products and firefighting foam -- alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.

21 Jan 2020

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis.

10 Jan 2020

Loss of stress hormone is a hallmark of pancreatitis, shows study

In work that could have clinical implications, UT Southwestern researchers find that humans and mice with pancreatitis are deficient in a stress hormone called FGF21.

9 Jan 2020

New mechanism that impairs Treg differentiation and stability in type 1 diabetes discovered

Regulatory T cells (Tregs) prevent excessive immune reactions in healthy people. In the development of autoimmune type 1 diabetes, this protection is not sufficiently effective.

19 Dec 2019

Lower life expectancy with intellectual disability

A new study published on December 2, 2019, in the Journal of Applied Research in Intellectual Disabilities shows why people with intellectual disabilities (ID) typically have a shorter life span compared to the general population. The UNSW Sydney researchers uncover factors that lead to a higher risk of death among people with ID.

2 Dec 2019

Mercy Medical Center to establish the Maryland Bariatric Center

Noted bariatric specialist Kuldeep Singh, MD, FACS, MBA, FASMBS, has joined Mercy Medical Center to establish a new clinical program: The Maryland Bariatric Center at Mercy, scheduled to open in January 2020. Dr. Singh will lead the new center as Medical Director.

26 Nov 2019

Recently discovered protein may play key role in obesity and metabolic disease

With unexpected findings about a protein that's highly expressed in fat tissue, scientists at Scripps Research have opened the door to critical new understandings about obesity and metabolism.

21 Nov 2019

Prior DDT exposure may contribute to diabetes risk among Asian Indian immigrants

Previous exposure to the pollutant DDT may contribute to the risk of diabetes among Asian Indian immigrants to the United States, according to a study from the University of California, Davis.

20 Nov 2019

Yale study uncovers why belly fat surrounding organs increases as people age

A study by researchers at Yale has uncovered why belly fat surrounding organs increases as people age, a finding that could offer new treatment possibilities for improving metabolic health, thereby reducing the likelihood for diseases like diabetes and atherosclerosis that stem from inflammation.

15 Nov 2019

Stress affects circadian rhythm, increases metabolic disease risk

Stress is a normal part of life, but too much of everything isn’t healthy. Every day, people from all walks of life experience stress of various degrees. A new study found that when stress has disrupted the circadian rhythm, the body’s internal clock, it can increase the risk of developing metabolic diseases.

12 Nov 2019

Study finds vitamin B12 deficiency in pregnancy may induce obesity

A new study which was presented at the annual conference of Society for Endocrinology reports that vitamin B12 deficiency could disrupt the normal metabolism of fat and could indirectly contribute to weight gain and obesity in pregnancy. This emphasizes the need supplement this vitamin during pregnancy, because obesity in pregnancy is linked to a number of adverse health outcomes over the long term, including diabetes.

12 Nov 2019

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.

10 Nov 2019

Father’s nutritional pattern affects child’s cardiovascular health

While couples often change their lifestyle in order to conceive faster, including crash diets, a new study in mice throws up the possibility that this kind of extreme dietary modification by the father might result in adverse effects on the child conceived in this manner.

17 Oct 2019