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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Skin biopsy can aid in early identification and differential diagnosis of Parkinson's disease

The diagnosis of Parkinson's disease (PD) is currently based on consensus clinical criteria. A novel study reported in the Journal of Parkinson's Disease has found that the presence of neuronal deposits of the biomarker phosphorylated alpha-synuclein (p-syn) in the brain and the skin of patients with PD distinguishes them from individuals with symptoms of parkinsonism due to the accumulation of another protein, tau.

15 Mar 2022

Sustainable material-based biosensors for SARS-CoV-2 detection

Researchers conducted a brief review on biosensors based on sustainable materials for SARS-CoV-2 detection.

15 Mar 2022

Role of carboxypeptidase U in severe COVID-19

A new study measured both proCPU and CPU+CPUi over time to determine the impact of SARS-CoV-2 infection on the CPU system.

14 Mar 2022

Blood test shows promise to identify Alzheimer's changes in the brain before symptom onset

The University of Kentucky's Sanders-Brown Center on Aging has been around for nearly half a century. In that time, they have built an international reputation for best-in-class research into a disease that kills more people every year than breast and prostate cancer combined – Alzheimer's disease.

10 Mar 2022

Molecular signature of microorganisms in stool samples could predict pancreatic cancer risk

Pancreatic cancer is not one of the most frequently diagnosed cancers, but it is one of the most lethal due to its early local extension and metastatic behavior.

9 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

In a recent study posted to the bioRxiv preprint server, researchers demonstrated that the soluble P2X7 receptor is increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients. They also showed that the elevated P2X7 receptors correlated with coronavirus disease 2019 (COVID-19) severity.

9 Mar 2022

Specific variant of the HLA-DPB1 gene linked with poor response to allergen immunotherapy

Although sublingual immunotherapy (SLIT) has become an effective treatment option for many allergies, about 20-30% of patients don’t respond to SLIT for Japanese cedar pollinosis–a highly common disease.

7 Mar 2022

What does the Future Look Like for Patient Centricity within Clinical Trials?

In this interview, we speak to Dr. Paresh Malhotra about what the future holds for patient centricity within clinical trials, and the benefits for this focus.

7 Mar 2022

Severity-dependent immune mechanisms in the cerebrospinal fluid and plasma of COVID-19 patients

Researchers determined the immune mechanisms associated with severe neurological manifestations of COVID-19.

7 Mar 2022

Potential molecular and clinical biomarkers of COVID-19 severity

Researchers have reviewed the currently published data examining the potential molecular and clinical biomarkers of COVID-19 severity.

4 Mar 2022

Study provides insight into what causes therapy failure in patients with myelodysplastic syndromes

Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells.

3 Mar 2022

Novel MRI approach can identify brain cell damage in people at early stages of Alzheimer's

Alzheimer's disease usually is diagnosed based on symptoms, such as when a person shows signs of memory loss and difficulty thinking.

2 Mar 2022

Researchers propose potential fixes to develop evidence-based diagnostic criteria for FMDs

Functional Movement Disorders (FMDs) are common and disabling conditions. With an increasing research interest in FMDs, including the emergence of intervention trials, it is crucial to examine research methodology and develop standardized protocols.

2 Mar 2022

Study explores signature gut microbiome connection with immune checkpoint inhibitor response in advanced melanomas

Researchers from different countries performed a meta-analysis of real-world cross-cohorts and provided an association of the gut microbiome with immune checkpoint inhibitors response in patients with advanced melanomas.

2 Mar 2022

Researchers launch a multi-center trial to investigate new treatment for pediatric type 1 diabetes

Researchers at Massachusetts General Hospital, in partnership with NYU Langone Health, have launched a multi-center clinical trial to investigate a new treatment for pediatric type 1 diabetes even in subjects with established disease.

1 Mar 2022

AI and machine learning could improve cancer diagnosis through biomarker discovery

Artificial intelligence (AI), deep learning (DL), and machine learning (ML) have transformed many industries and areas of science.

1 Mar 2022

COVID-19 severity is correlated with body composition

In a recent study posted to the medRxiv* preprint server, researchers assessed the effect of changes in the abdominal well-being and physique on coronavirus disease 2019 (COVID-19) severity using magnetic resonance imaging (MRI).

28 Feb 2022

Metabolites could be used as biomarkers for forensic diagnosis of diabetes mellitus

Determining the cause of death is one of the most crucial and challenging parts of a forensic investigation.

28 Feb 2022

Study provides new understanding of the earliest molecular events in Type 1 Diabetes pathogenesis

For the first time, researchers have revealed that during the development of Type 1 Diabetes (T1D), when insulin-producing cells in the pancreas are under attack from T lymphocytes, the cells lining the pancreatic duct reprogram themselves in an attempt to suppress autoimmune T cell responses.

28 Feb 2022

Biomarker News and Research

Further Reading

Skin biopsy can aid in early identification and differential diagnosis of Parkinson's disease

Sustainable material-based biosensors for SARS-CoV-2 detection

Role of carboxypeptidase U in severe COVID-19

Blood test shows promise to identify Alzheimer's changes in the brain before symptom onset

Molecular signature of microorganisms in stool samples could predict pancreatic cancer risk

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

Specific variant of the HLA-DPB1 gene linked with poor response to allergen immunotherapy

What does the Future Look Like for Patient Centricity within Clinical Trials?

Severity-dependent immune mechanisms in the cerebrospinal fluid and plasma of COVID-19 patients

Potential molecular and clinical biomarkers of COVID-19 severity

Study provides insight into what causes therapy failure in patients with myelodysplastic syndromes

Novel MRI approach can identify brain cell damage in people at early stages of Alzheimer's

Researchers propose potential fixes to develop evidence-based diagnostic criteria for FMDs

Study explores signature gut microbiome connection with immune checkpoint inhibitor response in advanced melanomas

Researchers launch a multi-center trial to investigate new treatment for pediatric type 1 diabetes

AI and machine learning could improve cancer diagnosis through biomarker discovery

COVID-19 severity is correlated with body composition

Metabolites could be used as biomarkers for forensic diagnosis of diabetes mellitus

Study provides new understanding of the earliest molecular events in Type 1 Diabetes pathogenesis

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