Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

The promise of RNA medicine is targeted and personalized

The development of messenger RNA (mRNA) vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has only increased the impetus in this field.

11 May 2022

COVID-19-induced non-cell-autonomous anosmia

Researchers reported that SARS-CoV-2-induced anosmia was based on non-cell-independent processes.

11 May 2022

Testis tissue frozen for more than two decades can produce viable sperm after reimplantation

A new study demonstrates that rat testis tissue frozen for over 20 years can be successfully transplanted into infertile mice to regenerate and produce sperm.

11 May 2022

Testicular tissue can be successfully frozen for over 20 years, study shows

Male testis tissue that is cryopreserved can be reimplanted after more than 20 years and will go on to make viable sperm, according to a new study in rodents in the open-access journal PLOS Biology by Eoin Whelan of the School of Veterinary Medicine, University of Pennsylvania and colleagues publishing May 10th.

10 May 2022

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

UNC School of Medicine Scientists have shown for the first time that postnatal gene therapy may be able to prevent or reverse many deleterious effects of a rare genetic disorder called Pitt-Hopkins syndrome.

10 May 2022

Exploring simultaneous and sequential COVID-19 vaccine candidate

Researchers developed novel lipid nanoparticle (LNP)-based messenger ribonucleic acid vaccine formulations against three pathogenic coronaviruses.

10 May 2022

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

9 May 2022

Study investigates the cause of lymphopenia as seen in COVID-19 patients

Researchers explored the underlying mechanism resulting in thymic atrophy and subsequent lymphopenia in COVID-19 patients.

9 May 2022

Changes in gut microbiome impact depression

Over the last five years, the effects of the gut microbiome on depression have gained scientific attention, resulting in a significant increase in research papers.

8 May 2022

Neuroscientists discover a new facet to caloric restriction that dramatically extends life span

A new study in mice led by neuroscientists at UT Southwestern's Peter O'Donnell Jr. Brain Institute shows that it's not just calories that count.

6 May 2022

Single-cell RNA sequencing reveals characteristics of myeloid immune cells in coronary plaque

Through single-cell RNA sequencing, a research group has successfully illuminated the characteristics of Myeloid immune cells in coronary plaque, which causes acute coronary syndrome (this term includes conditions such as unstable angina and acute myocardial infarction (heart attack)).

6 May 2022

Potential indirect and direct effects of SARS-CoV-2 on pancreatic islets in patients who became hyperglycemic after COVID-19

In a recent study published in Diabetes, researchers assessed the direct and indirect effects of SARS-CoV-2 on human pancreatic islets.

5 May 2022

New model can predict drug-drug interactions based on drug-induced gene expression signatures

Prescriptions for multiple drugs, or polypharmacy, is often recommended for the treatment of complex diseases.

4 May 2022

Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

Mitochondria serve as the main source of energy production in our cells, and endurance exercise is generally known to improve the function of mitochondria.

4 May 2022

Experts develop new method to control gene expression using electrical signals

Researchers have created an improved method for turning genes on and off using electrical signals.

4 May 2022

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease, and a study led by the University of California San Diego provides new evidence to support this claim.

4 May 2022

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

A recent study under review at Nature Portfolio and posted to the Research Square* preprint server depicted how cellular nucleic acid-binding protein (CNBP) inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 May 2022

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

Researchers demonstrated that plasma levels of leucine-rich repeat-containing 15 are a strong indicator of the severity of COVID-19 in patients with end-stage kidney disease.

3 May 2022

Precision cut slice lung model to study early host viral pathogenesis of SARS-CoV-2 infection

Researchers applied their previously developed precision-cut lung slice model to study the initial events in SARS-CoV-2 pathogenicity in humans.

3 May 2022

Antibiotics may disrupt microbiome to cause recurrent UTIs

A study by researchers at Washington University School of Medicine in St. Louis and the Broad Institute of MIT and Harvard suggests that women who get recurrent urinary tract infections (UTIs) may be caught in a vicious cycle in which antibiotics given to eradicate one infection predispose them to develop another.

2 May 2022

Gene Expression News and Research

Further Reading

The promise of RNA medicine is targeted and personalized

COVID-19-induced non-cell-autonomous anosmia

Testis tissue frozen for more than two decades can produce viable sperm after reimplantation

Testicular tissue can be successfully frozen for over 20 years, study shows

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

Exploring simultaneous and sequential COVID-19 vaccine candidate

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Study investigates the cause of lymphopenia as seen in COVID-19 patients

Changes in gut microbiome impact depression

Neuroscientists discover a new facet to caloric restriction that dramatically extends life span

Single-cell RNA sequencing reveals characteristics of myeloid immune cells in coronary plaque

Potential indirect and direct effects of SARS-CoV-2 on pancreatic islets in patients who became hyperglycemic after COVID-19

New model can predict drug-drug interactions based on drug-induced gene expression signatures

Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

Experts develop new method to control gene expression using electrical signals

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

Precision cut slice lung model to study early host viral pathogenesis of SARS-CoV-2 infection

Antibiotics may disrupt microbiome to cause recurrent UTIs

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

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Industry Focus eBook - Microbiome (1st edition)

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