Preclinical News and Research

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Cell competition could be responsible for cancer relapses, study shows

A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free, a new study by UT Southwestern Simmons Cancer Center researchers suggests.

8 Nov 2022

Researchers discover neuronal mechanism involved in the learning of maternal behavior

Various conditions such as postpartum depression or postpartum psychosis can lead to an alteration in maternal behavior and disrupt the mother-child bonding process.

8 Nov 2022

Beyond vaccines: emerging technologies capable of unlocking the promise of biologically targeted mRNA therapeutics

Researchers reviewed technology advancements that will unlock the promise of biologically targeted messenger ribonucleic acid (mRNA) therapeutics beyond vaccines.

7 Nov 2022

Dietary inulin fiber can promote allergy-related type of inflammation in the gut and lungs

A type of dietary fiber called inulin, commonly used in health supplements and known to have certain anti-inflammatory properties, can also promote an allergy-related type of inflammation in the lung and gut, and other parts of the body, according to a preclinical study from researchers in the Friedman Center for Nutrition and Inflammation and Jill Roberts Institute for Inflammatory Bowel Disease at Weill Cornell Medicine and in the Boyce Thompson Institute on Cornell's Ithaca campus.

2 Nov 2022

Study provides new set of targets for drug therapies to combat chronic inflammatory diseases

Innate lymphoid cells are a recently discovered family of white blood cells that reside in the skin, gastrointestinal tract, airways and other barrier tissues of the body.

2 Nov 2022

Study identifies a new therapeutic strategy to tackle endometrial cancer

Inhibition of the ERK5 protein kinase reduces the proliferation and survival of endometrial cancer cells, and potentiates standard chemotherapy.

2 Nov 2022

First preclinical model to study the pathobiology of appendiceal cancer

Appendiceal cancer (malignancies of the appendix, a small tissue pouch that is part of the gastrointestinal tract) is very rare, occurring in perhaps one or two people per 1 million per year.

1 Nov 2022

BCRF renews funding to support the development of novel therapeutics for triple-negative breast cancer

The Breast Cancer Research Foundation (BCRF) has renewed its funding to Elisa Port, MD, and Hanna Irie, MD, PhD, to study new therapeutic approaches that target aggressive triple-negative breast cancer.

31 Oct 2022

SpyCatcher-SpyTag technology used to develop recombinant protein-based intranasal vaccine against SARS-CoV-2

The findings of a new study showed that the intranasal SpyCage vaccine platform can be protective against SARS-CoV-2 and may prove to be a versatile and adaptable modality for the formulation of intranasal vaccines that target respiratory pathogens.

31 Oct 2022

An innovative nasal vaccine strategy to combat COVID

In a recent study published in the journal Science, researchers at Yale University developed a novel coronavirus disease 2019 (COVID-19) vaccination strategy termed 'prime and spike' (P&S) that leveraged existing systemic immunity triggered by parenteral vaccination (prime) to boost immunity at the respiratory mucosa.

31 Oct 2022

New device could help address racial disparities in hemoglobin and blood oxygen measurements

A team led by a University of Texas at Arlington bioengineering professor and an Austin businessman has published key findings in the British Medical Journal Innovations that illustrate how a new device measures hemoglobin more accurately in individuals with darker skin pigmentations.

28 Oct 2022

Novel nanotechnology triggers potent therapeutic anti-tumor immune responses against multiple cancers

A Ludwig Cancer Research study has developed a novel nanotechnology that triggers potent therapeutic anti-tumor immune responses and demonstrated its efficacy in mouse models of multiple cancers.

28 Oct 2022

Specific stem cell protein found to be involved in the recurrence of medulloblastoma

The malignant brain tumor type medulloblastoma can become resistant to therapy which can cause relapse. Researchers at Uppsala University have discovered a certain protein that makes tumor cells resting and insensitive to radiation treatment.

28 Oct 2022

Proof-of-principle study: Novel tool advances potential way to deliver gene therapy

Johns Hopkins Medicine researchers say they have successfully used a cell's natural process for making proteins to "slide" genetic instructions into a cell and produce critical proteins missing from those cells.

28 Oct 2022

Metabolite product from pomegranate improves the function of immune cells to fight against cancer

As part of an interdisciplinary project of the LOEWE Centre Frankfurt Cancer Institute (FCI), researchers from the Georg-Speyer-Haus in Frankfurt am Main, Germany, and Goethe University Frankfurt have succeeded in identifying a new approach for the therapy of colorectal cancer.

27 Oct 2022

$10.3 million NIH grant to support URI neuroscientist's research on retinal scanning to detect early-stage Alzheimer’s

Jessica Alber, assistant professor of biomedical and pharmaceutical sciences at the George & Anne Ryan Institute for Neuroscience at the University of Rhode Island, is looking to change the way doctors diagnose Alzheimer's disease, a change that could raise new possibilities for treatment.

26 Oct 2022

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

A new approach to cancer immunotherapy that uses one type of immune cell to kill another - rather than directly attacking the cancer - provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.

25 Oct 2022

Preclinical News and Research

Cell competition could be responsible for cancer relapses, study shows

Researchers discover neuronal mechanism involved in the learning of maternal behavior

Beyond vaccines: emerging technologies capable of unlocking the promise of biologically targeted mRNA therapeutics

Dietary inulin fiber can promote allergy-related type of inflammation in the gut and lungs

Study provides new set of targets for drug therapies to combat chronic inflammatory diseases

Study identifies a new therapeutic strategy to tackle endometrial cancer

First preclinical model to study the pathobiology of appendiceal cancer

BCRF renews funding to support the development of novel therapeutics for triple-negative breast cancer

SpyCatcher-SpyTag technology used to develop recombinant protein-based intranasal vaccine against SARS-CoV-2

An innovative nasal vaccine strategy to combat COVID

New device could help address racial disparities in hemoglobin and blood oxygen measurements

Novel nanotechnology triggers potent therapeutic anti-tumor immune responses against multiple cancers

Specific stem cell protein found to be involved in the recurrence of medulloblastoma

Proof-of-principle study: Novel tool advances potential way to deliver gene therapy

Metabolite product from pomegranate improves the function of immune cells to fight against cancer

$10.3 million NIH grant to support URI neuroscientist's research on retinal scanning to detect early-stage Alzheimer’s

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

Near-infrared spectroscopy can provide a cost-effective way to noninvasively monitor intracranial pressure

Combination of radiation and systemic therapy can prolong survival for advanced liver cancer patients

Study shows hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron sublineages

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics