Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

ESMO announces a new series of resources to guide physicians in oncological practice

ESMO, the leading professional organization for medical oncology, announces a new series of resources designed to guide physicians in areas of oncological practice not covered by guidelines, where current evidence is insufficient to evenly inform clinical decision-making.

28 Feb 2022

SARS-CoV-2 monitoring could be improved with use of bacterial metatranscriptomes in wastewater

In a recent research report from the United States, currently available on bioRxiv* preprint server, scientists have shown that bacterial taxonomic and functional profiles can discriminate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status even without directly detecting viral transcripts – opening the door for entirely novel approaches in wastewater-based epidemiology.

27 Feb 2022

DNA biomarker test helps predict recurrence of HPV-driven oropharyngeal cancer after treatment

A large, multi-institutional study demonstrates that a blood test to detect circulating tumor DNA can accurately predict recurrence of HPV-driven oropharyngeal cancer following treatment.

25 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

Circulating miR-155 may predict chances of survival in hospitalized COVID-19 patients

Scientists from Israel have recently estimated the levels of circulating microRNAs (miRNAs) in hospitalized coronavirus disease 2019 (COVID-19) patients with the aim of identifying prognostic biomarkers for disease severity. They have identified miR-155, an important regulatory molecule in the immune system, as a potential biomarker to predict COVID-19 severity and mortality.

22 Feb 2022

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

21 Feb 2022

Advanced imaging reveals the loss of brain synapses in patients with mild symptoms of Alzheimer's

Advanced imaging technology developed by Yale researchers has helped them confirm that the destruction of brain synapses underlies the cognitive deficits experienced by patients with Alzheimer's disease, according to a study published Feb. 17 in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

17 Feb 2022

New METPlatform allows researchers to test drugs for possible use in brain metastases

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments.

17 Feb 2022

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Joint study will assess clinical value of comprehensive genomic profiling (CGP) on cancer therapy options in patients with advanced disease

From Illumina, Inc. 17 Feb 2022

Biomarker could predict pathologic response to chemotherapy among bladder cancer patients

Long-term survival data from the first prospective, randomized biomarker validation trial in patients with muscle-invasive bladder cancer being treated with cisplatin-based chemotherapy before surgery will be reported at the 2022 Genitourinary Cancers Symposium of the American Society of Clinical Oncology (GU ASCO) on February 18, 2022.

15 Feb 2022

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

There is currently no effective treatment for facioscapulohumeral muscular dystrophy (FSHD), one of the most common neuromuscular diseases, which is caused by an abnormal expression of the transcription factor DUX4.

15 Feb 2022

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Findings by researchers from Germany support the view that hyperactive immune cells in the brain can have a protective effect in the course of neurodegenerative diseases.

14 Feb 2022

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

MUSC Hollings Cancer Center researcher Sophie Paczesny, M.D., Ph.D., recently received a four-year grant from the National Heart, Lung, and Blood Institute to investigate solutions to help doctors to fight complications after pediatric bone marrow transplantation (BMT).

12 Feb 2022

Nine new Discovery Grants awarded to fuel the development of ALS treatments

With promising new therapies for amyotrophic lateral sclerosis (ALS) on the horizon, now is the time for ongoing investment in research discovery that will continue to fuel the development of treatments.

10 Feb 2022

Researchers identify and characterize a previously unrecognized key player in cancer evolution

Researchers led by bioengineers at the University of California San Diego have identified and characterized a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome.

9 Feb 2022

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Drugs which are commonly-used as the first line of treatment for colorectal cancer cause the tumor cells to oversecrete proteins known as mucins, according to a new study published today in the journal eLife.

9 Feb 2022

Reviewing breath biomarkers for inflammatory respiratory diseases

The prevalence of inflammatory airway diseases such as lung cancer, chronic obstructive pulmonary disease (COPD) and asthma is on the rise internationally, placing strain on health systems around the world. Lung cancer is the leading cause of death of all cancers.

From Owlstone Medical Ltd 8 Feb 2022

Cerebrovascular impairment persists months after severe acute COVID-19, UK study

Researchers in the United Kingdom have conducted an observational cohort study on hospitalized patients and have found that the degree of severity of acute coronavirus disease 2019 (COVID-19) predicts the occurrence of chronic cerebrovascular impairment. The study further suggests that the levels of cerebrovascular impairment are associated with worse cognitive, mental, and physical well-being.

7 Feb 2022

Fuel poverty impacts people’s physical and mental health, study shows

The rocketing price of fuel could be making people’s physical and mental health worse – according to a new study from the University of East Anglia.

7 Feb 2022

Using interdisciplinary approach to beat cancer

European Cooperation in Science and Technology (COST) World Cancer Day aims at raising awareness of cancer and to encourage its prevention, detection, and treatment.

4 Feb 2022

Biomarker News and Research

Further Reading

ESMO announces a new series of resources to guide physicians in oncological practice

SARS-CoV-2 monitoring could be improved with use of bacterial metatranscriptomes in wastewater

DNA biomarker test helps predict recurrence of HPV-driven oropharyngeal cancer after treatment

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

Circulating miR-155 may predict chances of survival in hospitalized COVID-19 patients

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Advanced imaging reveals the loss of brain synapses in patients with mild symptoms of Alzheimer's

New METPlatform allows researchers to test drugs for possible use in brain metastases

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Biomarker could predict pathologic response to chemotherapy among bladder cancer patients

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

Nine new Discovery Grants awarded to fuel the development of ALS treatments

Researchers identify and characterize a previously unrecognized key player in cancer evolution

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Reviewing breath biomarkers for inflammatory respiratory diseases

Cerebrovascular impairment persists months after severe acute COVID-19, UK study

Fuel poverty impacts people’s physical and mental health, study shows

Using interdisciplinary approach to beat cancer

Event guide: 15th World Clinical Biomarkers & CDx Europe eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo