Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Scientists identify a way to reverse drug resistance by rewiring the inner workings of leukemia cells

Researchers from Barts Cancer Institute at Queen Mary University of London have identified a way to reverse resistance to a group of cancer drugs, known as kinase inhibitors, in leukemia cells.

19 Apr 2022

Scientists precisely define the ‘identity card’ of pancreatic endocrine cells

The pancreas is a key metabolic regulator. When pancreatic beta cells cease producing enough insulin, blood sugar levels rise dangerously — a phenomenon known as hyperglycemia — thus triggering diabetes.

19 Apr 2022

Better understanding of hydrocephalus could lead to improved treatments

Hydrocephalus, or "water on the brain," occurs when the cerebral ventricles - four interconnected cavities of the brain that are filled with cerebrospinal fluid - become enlarged, but its cause is unknown in many cases.

18 Apr 2022

Researchers identify 16 distinct cell populations in a key brain region for substance use disorders

In a work of systematic biology that advances the field, University of Alabama at Birmingham researchers have identified 16 distinct cell populations in a complex area of the midbrain called the ventral tegmental area, or VTA.

18 Apr 2022

Cell’s production of lipids can be a key factor in determining cell fate

How does a cell "decide" what type of cell to become? The question of "cell fate" has been explored for decades now, especially in the context of stem cell biology, but there are still gaps in our understanding.

15 Apr 2022

New data-driven mechanistic approach can help reduce drug costs and treat diseases

A new data-driven mechanistic approach that predicts cell types within tissue will help to reduce drug costs and treat diseases that were difficult to develop drugs for, according to a West Virginia University scientist.

14 Apr 2022

Maternal exercise during pregnancy improves metabolic health of offspring, shows study

A new study has demonstrated that maternal exercise during pregnancy improves the metabolic health of offspring, even when the mother is obese or on a high-fat diet.

14 Apr 2022

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

13 Apr 2022

Pod-based e-cigarette use alters the inflammatory state across multiple organ systems

Researchers at University of California San Diego School of Medicine report that daily use of pod-based e-cigarettes alters the inflammatory state across multiple organ systems including the brain, heart, lungs and colon. Effects also vary depending on the e-cigarette flavor, and can influence how organs respond to infections, such as SARS-CoV-2.

13 Apr 2022

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Researchers at The University of Texas MD Anderson Cancer Center have developed a new bioinformatics platform that predicts optimal treatment combinations for a given group of patients based on co-occurring tumor alterations.

12 Apr 2022

Study finds molecular features responsible for the development of metastatic breast cancer

Susana Garcia-Recio, PhD, a research associate in the lab of Charles M. Perou, PhD, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract LB176/4, Tuesday, April 12, 3:20 p.m. ET, Room 217-219, Ernest N. Morial Convention Center in New Orleans.)

11 Apr 2022

Chromatin accessibility as an early marker of severe COVID-19

A new study explores the possible use of chromatin remodeling in predicting a severe clinical trajectory for COVID-19.

11 Apr 2022

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Researchers assess the impact of interval administration of LD-IL-2 was examined in 18 T1D patients who received a three-day dosing interval.

10 Apr 2022

Machine learning and proteomics predict cardiovascular risk more accurately

An innovative proteomics-based model that predicts the risk of cardiovascular events with higher accuracy than current clinical models.

10 Apr 2022

MOFs could help improve the delivery of genetic cargo into target cells

Hybrid material helps ferry genetic cargo to target cells. An emerging type of material called a metal-organic framework(MOF) could help improve the delivery of genetic material for treating disease.

10 Apr 2022

City of Hope's late-breaking clinical trial data to be presented at AACR

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, will present late-breaking and clinical trial findings at this year's American Association for Cancer Research Annual Meeting, which begins today.

8 Apr 2022

Gene Expression News and Research

Further Reading

Scientists identify a way to reverse drug resistance by rewiring the inner workings of leukemia cells

Scientists precisely define the ‘identity card’ of pancreatic endocrine cells

Better understanding of hydrocephalus could lead to improved treatments

Researchers identify 16 distinct cell populations in a key brain region for substance use disorders

Cell’s production of lipids can be a key factor in determining cell fate

New data-driven mechanistic approach can help reduce drug costs and treat diseases

Maternal exercise during pregnancy improves metabolic health of offspring, shows study

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Pod-based e-cigarette use alters the inflammatory state across multiple organ systems

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Study finds molecular features responsible for the development of metastatic breast cancer

Chromatin accessibility as an early marker of severe COVID-19

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Machine learning and proteomics predict cardiovascular risk more accurately

MOFs could help improve the delivery of genetic cargo into target cells

City of Hope's late-breaking clinical trial data to be presented at AACR

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

Transcriptional reprogramming of monocytes in COVID-19

SEACells: an algorithm for identifying metacells

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