Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Experts question the role of white mulberry in the death of Congressman’s wife

Scientists, doctors, and pathologists are questioning the Sacramento County coroner's conclusion that Lori McClintock's death was related to white mulberry, a plant that has been used as an herbal remedy for centuries — and one that the coroner's botanical consultant called "not toxic" in a letter to her office.

14 Sep 2022

Scientists identify two distinct subtypes of obesity

A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication.

14 Sep 2022

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

In a recent study published in the journal eBioMedicine, researchers in Denmark and Sweden administered a cationic liposome-adjuvanted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine as a subcutaneous (s.c.) prime-intranasal (i.n.) boost strategy to elicit mucosal immune responses among SARS-CoV-2-infected Syrian hamsters.

14 Sep 2022

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Through extensive single-cell analysis, researchers at The University of Texas MD Anderson Cancer Center have created a spatial map of tumor-infiltrating B cells and plasma cells in early-stage lung cancers, highlighting previously unappreciated roles these immune cells play in tumor development and treatment outcomes.

13 Sep 2022

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain" - a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer.

13 Sep 2022

Molecular explanation for the contribution of autophagy to BAT energy metabolism

Obesity is a growing global health problem and its prevalence has tripled since 1975. More than 650 million people are affected by this condition worldwide, and 28% of people in Spain over 18 years of age have this complex pathology. Obesity is linked to conditions such as type II diabetes, cardiovascular disease, osteoarthritis, and certain forms of cancer.

13 Sep 2022

AI-based pathology diagnosis tool in development detects 7 types of gastric cancer

Evident, a wholly owned subsidiary of Olympus Corporation, announced the latest results from its ongoing joint research program to create an AI-based pathology diagnostic tool at the 20th annual meeting of the Japanese Society of Digital Pathology.

From Evident Corporation - Life Sciences 13 Sep 2022

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

In a recent study posted to the medRxiv* preprint server, researchers in Australia determined whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta-ORF7aΔ17del [open reading frame 7a protein with 17-nucleotide (nt) frameshift-inducing deletion] variant has a fitness advantage over the Delta variant lacking the ORF7aΔ17del deletion (Delta-ORF7aintact) and/or the SARS-CoV-2 lineage (A.2.2).

12 Sep 2022

N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

In a recent study posted to the bioRxiv* server, researchers in the United States demonstrated the efficacy of a novel biopolymer, N-dihydrogalactochitosan (GC), as an adjuvant for next-generation mucosal coronavirus disease 2019 (COVID-19) vaccine.

12 Sep 2022

Study reveals two distinct types of obesity with physiological and molecular differences

12 Sep 2022

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food".

9 Sep 2022

Individual COVID-19 infections include multiple variants of the SARS-CoV-2 virus, research shows

Researchers at Case Western Reserve University found wide genetic variation in SARS-CoV-2 viruses among 360 patients whose viral infections were genetically sequenced, showing that all individual infections include multiple variants of the virus.

9 Sep 2022

Factors influencing patient’s perception during COVID-19 recovery

A team of researchers characterized individual-level illness perception, both cognitive and emotional, following COVID-19.

9 Sep 2022

The evolution of humoral immune responses over the course of Epstein-Barr virus infection

Researchers explored probable humoral immune mechanisms related to EBV curtailment, besides neutralization, by a systematic emphasis on antibody fragment crystallizable-functional activities over the course of EBV infections.

9 Sep 2022

Stem cell-derived liver cell model could be a valuable tool for future studies on Ebola virus

Ebola virus causes serious infections in humans and in fatal cases, damage and dysfunction of the liver is often present, suggesting that the liver plays a decisive role in disease outcome.

8 Sep 2022

Donor iron deficiency produces no harmful effects on donated blood quality or donor wellbeing

Most of the U.S. blood supply comes from about 5 million altruistic volunteers who donate blood regularly. Frequent blood donation is known to result in iron deficiency in donors, which has led to concerns that the practice may not only diminish the quality of donated blood but also harm blood donors' health and quality of life.

8 Sep 2022

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during neural development.

8 Sep 2022

Pathology News and Research

Further Reading

Experts question the role of white mulberry in the death of Congressman’s wife

Scientists identify two distinct subtypes of obesity

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Molecular explanation for the contribution of autophagy to BAT energy metabolism

AI-based pathology diagnosis tool in development detects 7 types of gastric cancer

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

Study reveals two distinct types of obesity with physiological and molecular differences

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Individual COVID-19 infections include multiple variants of the SARS-CoV-2 virus, research shows

Factors influencing patient’s perception during COVID-19 recovery

The evolution of humoral immune responses over the course of Epstein-Barr virus infection

Stem cell-derived liver cell model could be a valuable tool for future studies on Ebola virus

Donor iron deficiency produces no harmful effects on donated blood quality or donor wellbeing

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

Recent literature reports on the role of the gut microbiome on human health and its effect on diseases

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

Researchers identify DNA regions associated with physical activity or leisure screen time

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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