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Brain receptor discovery opens door to new therapies for addiction and mental health

Researchers at the Icahn School of Medicine at Mount Sinai have uncovered insights into the potential mechanism of action of the antipsychotic medication asenapine, a possible therapeutic target for substance use and neuropsychiatric disorders.

2 Jan 2024

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.

27 Dec 2023

Unraveling nuanced roles of JAK inhibitors in inflammation

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues.

21 Dec 2023

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Despite their promise, immunotherapies fail to treat many cancers, including over 80% of some of the most advanced breast cancers.

20 Dec 2023

Stem cell heart tissue model paves the way for better understanding of tachycardia

Heart rates are easier to monitor today than ever before. Thanks to smartwatches that can sense a pulse, all it takes is a quick flip of the wrist to check your heart.

20 Dec 2023

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer's disease.

20 Dec 2023

Study reveals extensive postnatal neuronal migration in human entorhinal cortex

The human brain continues to be built after we are born for far longer than previously recognized, suggests research by Shawn Sorrells, assistant professor of neuroscience in the Kenneth P. Dietrich School of Arts and Sciences.

20 Dec 2023

New statistical technique improves disease prediction for people of African descent

A team of scientists from Icahn School of Medicine at Mount Sinai has developed a groundbreaking statistical technique, "BridgePRS," to enhance disease prediction in people of non-European ancestry, particularly those of African descent.

20 Dec 2023

Metrion Biosciences closes £3.7m new equity financing

Metrion Biosciences Limited (Metrion), the specialist ion channel CRO and drug discovery company, today announced that it has secured £3.5m in new equity financing, including £2.5m from lead investor Maven Capital Partners (Maven) and £1 million from existing investor, Gresham House Ventures (Gresham House).

From Metrion Biosciences Limited 20 Dec 2023

A novel stem cell solution for preventing ischemia-induced amputations

Across the United States, about 2 million people are living with an amputation and another 185,000 amputations occur every year, according to the Amputee Coalition, a Washington DC-based support group.

19 Dec 2023

Microfluidic chip design optimizes cancer exosome detection

Cancer, a leading cause of death globally, releases TDEs, tiny vesicles containing crucial bioactive components.

19 Dec 2023

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Amidst a backdrop of industry-wide hurdles like inflation, talent scarcities, and stringent regulatory landscapes, Nona Biosciences is showing great promise as an emerging global leader in biotechnology.

From Nona BioSciences 19 Dec 2023

‘They see a cash cow’: Corporations could consume $50 billion of opioid settlements

The marketing pitches are bold and arriving fast: Invest opioid settlement dollars in a lasso-like device to help police detain people without Tasers or pepper spray.

18 Dec 2023

Experimental drug paired with a standard-care medication offers hope for kidney disease patients

In a clinical trial of patients with chronic kidney disease, an experimental drug significantly reduced albuminuria - albumin in urine, a sign of kidney damage - for 50% of participants.

15 Dec 2023

$9M awarded to study HIV and substance use at intersection of vulnerable populations

The Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) received an annual award for $3 million funded by the NIH Office of AIDS Research.

15 Dec 2023

Unlocking radiation resistance: Missing protein key to suppressing cancer-fighting cells

A new study finds that radiation therapy (RT) suppresses a key protein called bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and activates immune suppressive cells.

15 Dec 2023

Hemoglobin-like protein plays an important role in the development of the heart, study finds

In a landmark study led by the University of Maryland School of Medicine, researchers discovered for the first time that a certain kind of protein similar to hemoglobin, called cytoglobin, plays an important role in the development of the heart.

15 Dec 2023

RNA-seq analysis reveals key factors in intervertebral disc degeneration

In a rapid communication published in the journal Genes & Diseases, researchers from Chongqing Medical University and Yongchuan Traditional Chinese Medicine Hospital of Chongqing have unveiled crucial insights into the factors that might influence Intervertebral Disc Degeneration (IDD).

15 Dec 2023

New AI framework can rapidly identify new use cases for existing therapeutics

Scientists at Klick Applied Sciences have created an artificial intelligence framework that can rapidly identify new use cases for existing therapeutics, according to findings presented Friday at the NeurIPS conference that could greatly improve the drug repurposing process and transform the pharmaceutical industry.

15 Dec 2023

Therapeutics News and Research

Brain receptor discovery opens door to new therapies for addiction and mental health

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

Unraveling nuanced roles of JAK inhibitors in inflammation

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Stem cell heart tissue model paves the way for better understanding of tachycardia

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

Study reveals extensive postnatal neuronal migration in human entorhinal cortex

New statistical technique improves disease prediction for people of African descent

Metrion Biosciences closes £3.7m new equity financing

A novel stem cell solution for preventing ischemia-induced amputations

Microfluidic chip design optimizes cancer exosome detection

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

‘They see a cash cow’: Corporations could consume $50 billion of opioid settlements

Experimental drug paired with a standard-care medication offers hope for kidney disease patients

$9M awarded to study HIV and substance use at intersection of vulnerable populations

Unlocking radiation resistance: Missing protein key to suppressing cancer-fighting cells

Hemoglobin-like protein plays an important role in the development of the heart, study finds

RNA-seq analysis reveals key factors in intervertebral disc degeneration

New AI framework can rapidly identify new use cases for existing therapeutics

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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