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Vitamin D deficiency may lead to stiffening of blood vessels

UV-B radiation in sunlight is the most important factor for the production of vitamin D, and that is why many people suffer from low levels of vitamin D during the winter months.

20 Jan 2014

Study indicates that smoking disrupts circadian clock function in both lungs and brain

As if cancer, heart disease and other diseases were not enough motivation to make quitting smoking your New Year's resolution, here's another wake-up call: New research published in the January 2014 issue of The FASEB Journal suggests that smoking disrupts the circadian clock function in both the lungs and the brain.

3 Jan 2014

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance, hyperalgesia

Currently, opioids are the standard treatment for chronic pain. Patients on opioids for long periods of time become desensitized to these drugs or become paradoxically hypersensitive to pain (hyperalgesia); however, the adaptive mechanisms are not well understood.

3 Jan 2014

Cognitive behavioral therapy reduces headache frequency, migraine-related disability in children

Among children and adolescents with chronic migraine, the use of cognitive behavioral therapy resulted in greater reductions in headache frequency and migraine-related disability compared with headache education, according to a study appearing in the December 25 issue of JAMA.

25 Dec 2013

Studies yield new insights into molecular mechanisms that underlie learning process

Learning requires constant reconfiguration of the connections between nerve cells. Two new studies now yield new insights into the molecular mechanisms that underlie the learning process.

22 Dec 2013

LSDF announces research and development grants to commercialize health-related technologies

The Life Sciences Discovery Fund (LSDF) today announced $1.1 million in five Proof of Concept grants to Washington for-profit and non-profit organizations to foster the translation of health-related products from the laboratory into the commercial marketplace.

19 Dec 2013

TGen, Nemucore, and Barrow collaboration aims for new drugs to treat glioblastoma

The Ben & Catherine Ivy Foundation today announced a $3 million grant to the Translational Genomics Research Institute (TGen), Nemucore Medical Innovations Inc., and Barrow Neurological Institute at St. Joseph's Hospital and Medical Center to help fund significant brain tumor research in Arizona.

18 Dec 2013

Research findings point to possible new strategy for treating ALS

Amyotrophic lateral sclerosis, better known as Lou Gehrig's disease, is a devastating illness that gradually robs sufferers of muscle strength and eventually causes a lethal, full-body paralysis. The only drug available to treat the disease extends life spans by a meager three months on average.

17 Dec 2013

Stem cell technology: an interview with Professor Igor Slukvin, University of Wisconsin-Madison and scientific founder of CDI and Cynata

Stem cells have a potential to develop into multiple cell types and divide without limit to replenish cells in human body throughout the life of individual.

16 Dec 2013

Health Improvement Institute Founder announces recipients of 2013 Human Research Protection Award

Awards for Excellence in Human Research Protection for 2013 were announced today by Dr. Peter G. Goldschmidt, President and Founder of the Health Improvement Institute.

12 Dec 2013

Ribosomal proteins RPL5, RPL11 play essential role in normal cell proliferation

Researchers from the Laboratory of Cancer Metabolism (LCM) led by George Thomas at the Bellvitge Biomedical Research Institute (IDIBELL), the Catalan Institute of Oncology (ICO) and the Division of Hematology/ Oncology, University of Cincinnati, have shown that loss of either one of two tumor suppressors, ribosomal proteins RPL5 or RPL11, fail to induce cell-cycle arrest, but prevent the proliferation of cells as they have a reduced capacity to synthesize proteins.

12 Dec 2013

New Journal presents techniques for finding new uses for approved drugs

Mary Ann Liebert, Inc., publishers is pleased to announce Drug Repurposing, Rescue, and Repositioning, a dynamic new peer-reviewed journal that will present techniques and tools for finding new uses for approved drugs—particularly for disorders where no animal model, physiologic abnormality, biochemical pathway, or molecular target has been identified.

12 Dec 2013

NIH data-sharing may advance genetic and translational research, therapeutic target discovery

For the first time, large-scale information on the biochemical makeup of small interfering RNA (siRNA) molecules is available publicly. These molecules are used in research to help scientists better understand how genes function in disease.

12 Dec 2013

Viewpoints: Optimism about Obamacare; 834 errors; can-you-keep-your-doctor debate

This was the week when liberals decided that it was safe to feel optimistic about Obamacare again. ... A worst-case scenario, in which the website remained unusable well into the new year, seems to have been averted, and with it the danger that insurers or Congressional Democrats would begin to bail on Obamacare entirely.

10 Dec 2013

Scientists target protein-detection approach to systematically measure human repertoire of proteins

An international team of scientists led by Fred Hutchinson Cancer Research Center cancer proteomics expert Amanda Paulovich, M.D., has demonstrated the feasibility of large-scale, standardized protein measurements, which are necessary for validation of disease biomarkers and drug targets.

9 Dec 2013

Finding identifies new mechanism that could contribute to the pathology of ALS

RNA molecules, used by cells to make proteins, are generally thought to be "silent" when stowed in cytoplasmic granules. But a protein mutated in some ALS patients forms granules that permit translation of stored RNAs, according to a study in The Journal of Cell Biology. The finding identifies a new mechanism that could contribute to the pathology of the disease.

4 Dec 2013

Study identifies high burden of pain in older adults

More than half of older adults in the United States - an estimated 18.7 million people - have experienced bothersome pain in the previous month, impairing their physical function and underscoring the need for public health action on pain. Many of those interviewed by investigators for a study published in the current issue of PAIN- reported pain in multiple areas.

3 Dec 2013

Enzyme intervenes when cancer-fighting PTEN is bound for cell's protein-destroying machinery

A protector for PTEN, a tumor-thwarting protein often missing in cancer cells, has emerged from research led by scientists at The University of Texas MD Anderson Cancer Center published online at Nature Cell Biology this week.

28 Nov 2013

UMass Medical School licenses "anti-gal" technology to Agalimmune

The University of Massachusetts Medical School has licensed "anti-gal" technology developed by Professor of Surgery and Medicine Uri Galili, PhD, to newly formed biopharmaceutical company Agalimmune Ltd. for the purpose of developing innovative immunotherapies for the treatment of solid tumor cancers. Agalimmune is supported by an investment group comprising Loxbridge Research LLP and Animatrix Capital LLP and is based in London and California.

27 Nov 2013

Research: Human neural stem cells could improve blood flow in critical limb ischemia

New research has shown human neural stem cells could improve blood flow in critical limb ischemia through the growth of new vessels. Critical limb ischemia is a disease that severely obstructs arteries and reduces the blood flow to legs and feet. CLI remains an unmet clinical problem and with an ageing population and the rise in type II diabetes, the incidence of CLI is expected to increase.

27 Nov 2013

Translation News and Research

Vitamin D deficiency may lead to stiffening of blood vessels

Study indicates that smoking disrupts circadian clock function in both lungs and brain

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance, hyperalgesia

Cognitive behavioral therapy reduces headache frequency, migraine-related disability in children

Studies yield new insights into molecular mechanisms that underlie learning process

LSDF announces research and development grants to commercialize health-related technologies

TGen, Nemucore, and Barrow collaboration aims for new drugs to treat glioblastoma

Research findings point to possible new strategy for treating ALS

Stem cell technology: an interview with Professor Igor Slukvin, University of Wisconsin-Madison and scientific founder of CDI and Cynata

Health Improvement Institute Founder announces recipients of 2013 Human Research Protection Award

Ribosomal proteins RPL5, RPL11 play essential role in normal cell proliferation

New Journal presents techniques for finding new uses for approved drugs

NIH data-sharing may advance genetic and translational research, therapeutic target discovery

Viewpoints: Optimism about Obamacare; 834 errors; can-you-keep-your-doctor debate

Scientists target protein-detection approach to systematically measure human repertoire of proteins

Finding identifies new mechanism that could contribute to the pathology of ALS

Study identifies high burden of pain in older adults

Enzyme intervenes when cancer-fighting PTEN is bound for cell's protein-destroying machinery

UMass Medical School licenses "anti-gal" technology to Agalimmune

Research: Human neural stem cells could improve blood flow in critical limb ischemia

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