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Researchers develop model for SARS-CoV-2 fusion intermediate that helps membrane fusion

The spike protein is the main part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the infection. It consists of two subunits S1 and S2. Upon entry of the virus into the human body, the S1 subunit helps the virus bind to the angiotensin-converting enzyme 2 (ACE2) receptors on host cells.

13 Apr 2021

A host of mutations could compromise COVID-19 vaccines and antibody therapies

Researchers in the United States have identified 95 high-frequency mutations in the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that threaten to compromise the efficacy of current and future vaccines and antibody therapies for coronavirus disease 2019 (COVID-19).

13 Apr 2021

Brachytherapy may proceed safely in cervical cancer patients following uterine perforation

A new study finds that brachytherapy, a common procedure that delivers radiation directly to cancer cells, may continue safely, potentially without delay or antibiotics, in cervical cancer patients following uterine perforation.

13 Apr 2021

Brooks Instrument Makes ISO/IEC 17025 Certification Available on SLA Series Biotech Mass Flow Controllers

Brooks Instrument has made the ISO/IEC 17025 certification available as an option on its SLA Series Biotech mass flow controllers (MFC).

From Brooks Instrument 13 Apr 2021

Zipper motif mediates SARS-CoV-2 spike trimerization within host cell membrane

A new preprint research paper posted to the bioRxiv* server describes the results of a nuclear magnetic resonance (NMR) study to determine the structure of the S protein transmembrane domain (TMD) and its membrane-proximal regions.

13 Apr 2021

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Even as vaccines against SARS-CoV-2 are being developed and administered at an unprecedented pace, treating this infection remains a challenge. To address this, researchers from China have used nanobodies (Nb) as a possible therapeutic approach. They reported Nb phage display libraries derived from four camels immunized with the SARS-CoV-2 spike RBD.

12 Apr 2021

New polypeptide could provide universal protection against coronaviruses

Researchers in the United States have developed an inhibitor of the spike protein found on the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that limits its formation in host human cells that would otherwise be the source of newly generated virions.

11 Apr 2021

FAIR Health adds new tools to support consumers as they navigate the healthcare system

The national, independent nonprofit FAIR Health is unveiling three new enhancements to its platform of online resources to support consumers as they navigate the healthcare system.

9 Apr 2021

Anticoagulation should not be regarded as primary cause of intracerebral haemorrhages, finds study

Cardiovascular diseases are usually complex and affect multiple organs simultaneously. Treatments for vascular diseases in the brain may therefore have implications for the treatment of cardiac diseases. It is therefore important to understand the respective causes and effects.

8 Apr 2021

USGS study finds high levels of arsenic and uranium in private well water across Connecticut

A new U.S. Geological Survey study provides an updated, statewide estimate of high levels of naturally occurring arsenic and uranium in private well water across Connecticut.

7 Apr 2021

Study shows stronger link between Down syndrome and acute myeloid leukemia

A new large-scale study led by UC Davis Health and UC San Francisco researchers assessed the risks of leukemia in children with Down syndrome.

7 Apr 2021

First general selection criteria for lung transplantation in Covid-19 patients

In May 2020, a team led by thoracic surgeon Konrad Hoetzenecker of the Department of Surgery of MedUni Vienna and Vienna General Hospital performed a lung transplant on a 44-year-old patient who had been seriously ill with Covid-19, making her the first patient in Europe to receive a lung transplant for this indication.

2 Apr 2021

Mice experiencing hallucination-like events provide clues to understand psychosis

The humble lab mouse has provided invaluable clues to understanding diseases ranging from cancer to diabetes to COVID-19. But when it comes to psychiatric conditions, the lab mouse has been sidelined, its rodent mind considered too different from that of humans to provide much insight into mental illness.

1 Apr 2021

FDA waiver broadens the use of chlamydia and gonorrhea test at more point-of-care settings

Today, the U.S. Food and Drug Administration announced it is allowing the use of the Binx Health IO CT/NG Assay at point-of-care settings, such as in physician offices, community-based clinics, urgent care settings, outpatient health care facilities and other patient care settings, operating under a CLIA Certificate of Waiver, Certificate of Compliance or Certificate of Accreditation.

30 Mar 2021

UVA expert helps develop new lung cancer screening guidelines for high-risk patients

Through his role on the U.S. Preventive Services Task Force, UVA Health's Li Li, MD, PhD, MPH, has helped develop new lung cancer screening guidelines that expand screenings to more high-risk patients.

30 Mar 2021

Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents

A new study deals with the effect of two widely used vaccines in eliciting humoral immunity against the virus in this group. These are the Oxford/AstraZeneca viral-vectored vaccine (ChAdOx1 nCoV-19), and the Pfizer/BioNTech’s messenger RNA-based vaccine (BNT162b2). Both express the viral spike antigen, and both are currently being employed in the UK’s vaccination program.

30 Mar 2021

New study reports increased spread of B.1.1.7 variant in Houston, Texas

Research led by Jimmy Gollihar from the CCDC Army Research Laboratory-South in Austin, Texas found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.7 —first detected last fall in England — increased in Houston, Texas. The B.1.1.7 variant is rapidly spreading with a case doubling time of 6.9 days.

29 Mar 2021

Study shows safety, efficacy of percutaneous thermal ablation for treating metastatic gynecologic cancers

A new study by researchers at the UCLA Jonsson Comprehensive Cancer Center found using percutaneous image guided needle based thermal ablation -- the precise application of extreme heat or cold to a tumor using sophisticated ultrasound, CT or MRI in a single outpatient session -- is a safe and effective adjunctive therapy for the local control of metastatic gynecologic cancers throughout lungs, liver, soft tissues in the abdomen and pelvis and bones in patients with advanced localized cancers unresponsive to systemic therapy.

29 Mar 2021

Rare genetic variant may explain severe COVID-19 in young healthy male patients

A recent study describes the association of rare alleles in a specific gene with severe COVID-19 in young male patients.

29 Mar 2021

Researchers develop new rapid and highly sensitive SAR-CoV-2 RNA detection test

In an alternative approach to the PCR-based methods, CRISPR-Cas proteins have been employed by a large team of researchers to identify the SARS-CoV-2 genomic RNA in patient samples with PCR-derived cycle threshold (Ct) values up to 22 - corresponding to ~1600 copies/µl in the assay.

29 Mar 2021

CT News and Research

Researchers develop model for SARS-CoV-2 fusion intermediate that helps membrane fusion

A host of mutations could compromise COVID-19 vaccines and antibody therapies

Brachytherapy may proceed safely in cervical cancer patients following uterine perforation

Brooks Instrument Makes ISO/IEC 17025 Certification Available on SLA Series Biotech Mass Flow Controllers

Zipper motif mediates SARS-CoV-2 spike trimerization within host cell membrane

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

New polypeptide could provide universal protection against coronaviruses

FAIR Health adds new tools to support consumers as they navigate the healthcare system

Anticoagulation should not be regarded as primary cause of intracerebral haemorrhages, finds study

USGS study finds high levels of arsenic and uranium in private well water across Connecticut

Study shows stronger link between Down syndrome and acute myeloid leukemia

First general selection criteria for lung transplantation in Covid-19 patients

Mice experiencing hallucination-like events provide clues to understand psychosis

FDA waiver broadens the use of chlamydia and gonorrhea test at more point-of-care settings

UVA expert helps develop new lung cancer screening guidelines for high-risk patients

Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents

New study reports increased spread of B.1.1.7 variant in Houston, Texas

Study shows safety, efficacy of percutaneous thermal ablation for treating metastatic gynecologic cancers

Rare genetic variant may explain severe COVID-19 in young healthy male patients

Researchers develop new rapid and highly sensitive SAR-CoV-2 RNA detection test

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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