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Genetic variants associated with Parkinson's more common than estimated

New research has found that genetic variants associated with Parkinson's disease (PD) are more common than researchers previously believed. Investigators in the Parkinson's Foundation-backed PD GENEration study – which reached its goal of 15,000 participants ahead of schedule this spring – found that 13% of participants have a genetic form of PD, which is a significant observation compared to long-standing estimates. Results from the first 3.5 years of the study, which examined a broad North American cohort, were published in the peer-reviewed scientific journal Brain.

30 Jul 2024

Physical activity and positive affect boost cognition in women with fibromyalgia despite pain

Researchers found that physical activity and positive affect can improve cognitive performance in women with fibromyalgia, even when pain severity is high. Promoting both may alleviate chronic pain's impact on cognition.

29 Jul 2024

New scoring system enhances identification of HFpEF patients

A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute, demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF).

29 Jul 2024

New blood test achieves 90% accuracy in diagnosing Alzheimer’s disease, outperforms doctors

Researchers in Sweden developed a combined blood test with up to 90% accuracy for diagnosing Alzheimer's disease, surpassing the diagnostic rates of primary care doctors and specialists.

29 Jul 2024

Asbestos exposure and carcinogenicity: A comprehensive review

Asbestos, a group of naturally occurring fibrous minerals, has been historically used for its durability and resistance to heat.

29 Jul 2024

Understanding iron overload in β-thalassemia: Mechanisms, diagnosis, and treatments

β-Thalassemia is a genetic disorder characterized by reduced or absent synthesis of the beta chains of hemoglobin, leading to ineffective erythropoiesis and severe anemia.

29 Jul 2024

Wearable, non-invasive device can measure activity in human cervical nerves in clinical settings

A research team led by UC San Diego has, for the first time, shown that a wearable, non-invasive device can measure activity in human cervical nerves in clinical settings.

29 Jul 2024

Machine learning revolutionizes Parkinson's disease symptom tracking and progression prediction

Research develops an automated system using machine learning to quantify motor symptoms in Parkinson's disease and predict disease progression, offering new therapeutic insights.

28 Jul 2024

The CDC’s test for bird flu works, but it has issues

The Centers for Disease Control and Prevention says a glitch in its bird flu test hasn't harmed the agency's outbreak response. But it has ignited scrutiny of its go-it-alone approach in testing for emerging pathogens.

26 Jul 2024

COVID pandemic accelerated brain aging, especially in males and deprived groups

The COVID-19 pandemic accelerated brain aging, particularly in males and those from deprived backgrounds, with significant cognitive performance decline in infected individuals. This impact was observed regardless of COVID-19 infection status, highlighting the role of psychosocial stressors.

25 Jul 2024

Closing the radiology gender gap: Progress and challenges ahead

The radiology gender gap is decreasing, but there remains work to be done, according to an editorial published today in RadioGraphics, a journal of the Radiological Society of North America (RSNA).

25 Jul 2024

Finnish research reveals higher incidence of early-onset dementia among working-age adults

A new major study by the University of Eastern Finland, the University of Oulu and Neurocenter Finland explored early-onset dementia in the working-age population in Finland.

25 Jul 2024

Study reveals moderate burden of post-COVID conditions in primary care

The post-COVID-19 conditions (PCC) or long COVID prevalence among United States (US) adults infected with SARS-CoV-2.

25 Jul 2024

Comprehensive analysis of Alzheimer’s brain tissue identifies novel biomarkers

From studying the human genome, to analyzing the way proteins are encoded, or monitoring RNA expression, researchers are rapidly gaining a far richer understanding of the complex genetic and cellular mechanisms that underpin dementia. But there's a catch: While new technologies are revealing myriad avenues for Alzheimer's research, it's impossible to know in advance which research pathways will lead to effective treatments.

25 Jul 2024

New insights into p16 protein could lead to advances in cancer diagnosis and treatment

Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis of various cancers.

25 Jul 2024

Study links social vulnerability to mental health and substance use disorders

A new study published in JAMA Psychiatry uncovers significant associations between social vulnerability - a measurement that aggregates social determinants of health like socioeconomic status, housing type, education and insurance coverage - and the prevalence and treatment of mental health and substance use disorders in the United States.

24 Jul 2024

Boosting ketone levels enhances heart function in mice with HFpEF, study shows

Increasing ketone supply to the heart in mice with heart failure with preserved ejection fraction (HFpEF) allowed their hearts to utilize more ketones and produce more energy, according to preliminary research presented today at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2024.

24 Jul 2024

Proteomic signatures enhance risk prediction for both common and rare diseases

Researchers have developed sparse prediction models combining plasma proteins and clinical data to predict the 10-year risk of 218 diseases. The study, involving over 41,000 participants, highlights the enhanced predictive power of proteomic signatures.

24 Jul 2024

AI model Virchow outperforms clinical methods in cancer detection

In a recent study published in Nature Medicine, researchers demonstrated the use of the foundational model Virchow for computational analysis of pathological reports, prediction of biomarkers, and identification of cells across multiple cancer types. Virchow's pan-cancer model showed impressive accuracy, often outperforming clinical-grade models.

23 Jul 2024

Researchers develop accurate and rapid method for diagnosing genetic disorders

Despite rapid advances in genetic testing in recent decades, more than half of people worldwide with suspected Mendelian genetic disorders do not have an accurate molecular diagnosis.

23 Jul 2024